Yazar "Menteşe, Ahmet" için listeleme
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Gentisic acid ameliorates cisplatin-induced reprotoxicity through suppressing endoplasmic reticulum stress and upregulating Nrf2 pathway
Menteşe, Ahmet; Demir, Selim; Aydın Mungan, Sevdegül; Alemdar, Nihal Türkmen; Ayazoğlu Demir, Elif; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)Reproductive toxicity is a serious side effect of cisplatin (CP) chemotherapy. Gentisic acid (GTA) is a phenolic acid with strong antioxidant properties. Here, we aimed to determine therapeutic effect of GTA against ... -
An investigation of the protective effect of rhododendron luteum extract on cisplatin-induced DNA damage and nephrotoxicity and biochemical parameters in rats
Turan, İbrahim; Canbolat, Deniz; Demir, Selim; Kerimoğlu, Gökçen; Çolak, Fatih; Alemdar, Nihal Türkmen; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (University of Agriculture, 2023)The nephrotoxicity mechanisms caused by cisplatin (CP), which is used in the treatment of different types of cancer, include several processes, such as DNA damage, apoptosis, inflammation, and oxidative stress. This study ... -
Investigation of the relationship between oxidative stress and SCUBE1 levels in high fat diet-induced obese rats
Bodur, Akın; Kahraman, Cemil; Altay, Diler Us; Rendı, Taghi Ahmadi; Menteşe, Ahmet; Alver, Ahmet (2018)Background/aim: This study aimed to investigate signal peptide-Cub-EGF domain-containing protein 1 (SCUBE1) levels and oxidative stress (OS) in a high fat diet (HFD)-induced obese rat model. Materials and methods: Fourteen ... -
Medical ozone therapy reduces oxidative stress and testicular damage in an experimental model of testicular torsion in rats
Tusat, Mustafa; Menteşe, Ahmet; Demir, Selim; Alver, Ahmet; İmamoğlu, Mustafa (Brazilian Soc Urol, 2017)Objective: Testicular torsion (TT) refers to rotation of the testis and twisting of the spermatic cord. TT results in ischemia-reperfusion (I/R) injury involving increased oxidative stress, inflammation and apoptosis, and ... -
N-acetylcysteine ameliorates 5-fluorouracil-induced ovarian injury in rats
Demir, Elif Ayazoğlu; Menteşe, Ahmet; Küçük, Hatice; Alemdar, Nihal Türkmen; Demir, Selim; Aliyazıcıoğlu, Yüksel (Marmara Üniversitesi, 2023)Objective: Although 5-fluorouracil (5-FU) is one of the most commonly used chemotherapeutics worldwide, it has been shown that 5-FU administration can cause reproductive toxicity in recent years. N-acetylcysteine (NAC) is ... -
Oxidative status in patients with Crimean-Congo hemorrhagic fever
Yılmaz, H.; Aksoy, Firdevs; Demir, Selim; Kostakoğlu, Uğur; Menteşe, Ahmet; Karahan, Süleyman Caner; Köksal, İftihar (Wiley-Blackwell, 2016).... -
p-Coumaric acid alleviates cisplatin-induced ovarian toxicity in rats
Ayazoğlu Demir, Elif; Menteşe, Ahmet; Küçük, Hatice; Türkmen Alemdar, Nihal; Demir, Selim (Wiley, 2021)Objective The therapeutic value of cisplatin (CDDP) as an anticancer drug is limited by its ovo-otoxicity. The effect of natural phenolic acids in the prevention of many diseases related to oxidative stress has been reported. ... -
Prognostic impact of platelet distribution width in patients With crimean-congo hemorrhagic fever
Yılmaz, Hülya; Yılmaz, Gürdal; Menteşe, Ahmet; Kostakoğlu, Uğur; Karahan, Süleyman Caner; Köksal, Iftihar (Wiley-Blackwell, 2016)Platelet distribution width (PDW) is a readily available blood test involving calculations performed by automated blood analyzers. Crimean-Congo hemorrhagic fever (CCHF) may exhibit a severe profile with fatal hemorrhaging ... -
The prognostic significance of serum TGF-β1 levels in patients with Crimean-Congo hemorrhagic fever.
Yılmaz, Gürdal; Yılmaz, Hülya; Arslan, Mustafa; Kostakoğlu, Uğur; Menteşe, Ahmet; Karahan, Süleyman Caner; Köksal, İftihar (John Wiley and Sons Inc., 2017)Crimean-Congo Hemorrhagic Fever (CCHF) may exhibit a mild clinical course or a severe profile like mortal bleeding. The pathogenesis of the illness and reason of bleeding are unclear. However, endothelial injury is a key ... -
Protective effect of clotrimazole on lung injury in an experimental model of ruptured abdominal aortic aneurysm
Pulathan, Zerrin; Ergene, Şaban Murat; Altun, Gökalp; Yuluğ, Esin; Menteşe, Ahmet (Wroclaw Medical University, 2024)Background. Lungs are the target organs most affected by ischemia/reperfusion (I/R) injury, which is exacerbated when hemorrhagic shock occurs. Suppressing various proinflammatory cytokines, inflammation and oxidation that ... -
Serum carbonic anhydrase I and II autoantibodies in patients with chronic lymphocytic leukaemia
Menteşe, Ahmet; Erkut, Nergiz; Demir, Selim; Yaman, Serap Özer; Sümer, Ayşegül; Erdem, Mehmet; Alver, Ahmet; Sönmez, Mehmet Giray (Termedia Publishing House Ltd, 2018)Cancer is the second most important cause of mortality, and millions of people either have or have had the disease. Leukaemia is one of the most common forms of cancer. Autoantibodies that have developed against the ... -
Suppression of cisplatin-induced ovarian injury in rats by chrysin: an experimental study
Menteşe, Ahmet; Türkmen Alemdar, Nihal; Livaoğlu, Ayten; Demir, Elif Ayazoğlu; Aliyazıcıoğlu, Yüksel; Demir, Selim (Taylor & Francis Ltd., 2022)The aim of this study was to investigate the potential therapeutic efficacy of chrysin (CHS) against ovotoxicity caused by intraperitoneal administration of cisplatin (CDDP) in rats. In this experimental study, 24 female ... -
Syringic acid ameliorates ischemia/reperfusion-induced testicular injury in rats via suppressing of HMGB1/NF-kappa B axis and endoplasmic reticulum stress
Demir, Elif Ayazoğlu; Demir, Selim; Kazaz, İlke Onur; Küçük, Hatice; Alemdar, Nihal Türkmen; Geçici, Ömer Faruk; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Springer, 2023)PurposeTo investigate the possible protective role of syringic acid on torsion/detorsion-induced testicular injury using biochemical and histopathological approaches for the first time.MethodsA total of 24 rats were divided ... -
The therapeutic effect of silibinin against 5-fluorouracil-induced ovarian toxicity in rats
Demir, Elif Ayazoğlu; Menteşe, Ahmet; Küçük, Hatice; Alemdar, Nihal Türkmen; Demir, Selim (Wiley, 2023)5-Fluorouracil (5-FU) is a fluoropyrimidine group antineoplastic drug with antimetabolite properties and ovotoxicity is one of the most important side effects. Silibinin (SLB) is a natural compound that is used worldwide ... -
Vanillic acid abrogates cisplatin-induced ovotoxicity through activating Nrf2 pathway
Menteşe, Ahmet; Demir, Selim; Küçük, Hatice; Yuluğ, Esin; Alemdar, Nihal Türkmen; Demir, Elif Ayazoğlu; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)Although cisplatin (CDDP) is an effective anticancer agent, the ovotoxicity that can occur in female patients limits its use. Oxidative stress (OS) and inflammation are known to contribute to CDDP-induced ovotoxicity. ...