Yazar "Mercantepe, Tolga" için listeleme
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Effects of mineral trioxide aggregate and methyl sulfonyl methane on pulp exposure via RUNX2 and RANKL pathways
Ateş, Altar; Kurt, Ayça; Mercantepe, Tolga (Springer Link, 2024)The aim of this study was to determine the therapeutic effects of mineral trioxide aggregate (MTA) and methyl sulfonyl methane (MSM) on pulp damage due to pulp exposure through the RUNX2 and RANKL pathways. Seventy-two ... -
The effects of mobile phone exposure on mast cells in rat dura mater
Tümkaya, Levent; Kalkan, Yıldıray; Gökçe, Fatih Mehmet; Erdivanlı, Başar; Yılmaz, Adnan; Bahçeci, İlkay; Yazıcı, Zihni Açar; Mercantepe, Tolga (Soc Chilena Anatomia, 2019)Mobile phone use has increased rapidly. the central nervous system has been shown to be adversely affected by its electromagnetic field (EMF) resulting in headache and sleep disturbances. How the cells make up the CNS and ... -
Effects of ozone pretreatment on viability of random pattern skin flaps in rats
Öksüz, Mustafa; Yüce, Serdar; Koçak, Ömer Faruk; Canbaz, Yasin; Rağbetli, Murat Çetin; Mercantepe, Tolga (Taylor and Francis Ltd, 2015)Background: Medical ozone is a chemical agent that consists of three oxygen atoms and has antioxidant, angiogenic and vasodilator effects. This study evaluated the effects of medical ozone pre-treatment on flap survival. ... -
The effects of prenatal exposure to a 900-MHz electromagnetic field on the 21-day-old male rat heart
Türedi, Sibel; Hancı, Hatice; Topal, Zehra; Ünal, Deniz; Mercantepe, Tolga; Bozkurt, İlyas; Kaya, Haydar; Odacı, Ersan (Taylor & Francis Inc, 2015)The growing spread of mobile phone use is raising concerns about the effect on human health of the electromagnetic field (EMF) these devices emit. the purpose of this study was to investigate the effects on rat pup heart ... -
The effects of prenatal long-duration exposure to 900-MHz electromagnetic field on the 21-day-old newborn male rat liver
Suzan, Zehra Topal; Hancı, Hatice; Mercantepe, Tolga; Erol, Hüseyin Serkan; Keleş, Osman Nuri; Kaya, Haydar; Mungan, Sevdegül; Odacı, Ersan (Tübıtak Scıentıfıc & Technıcal Research Councıl Turkey, 2015)Background/aim: To determine what efect a 900-MHz electromagnetic feld (EMF) applied in the prenatal period would have on the liver in the postnatal period. Materials and methods: At the start of the study, adult pregnant ... -
The effects of TNF-alpha inhibitors on carbon tetrachloride-induced nephrotoxicity
Özdemir, Ali; Tümkaya, Levent; Kalcan, Süleyman; Uyan, Mikail; Karakaya, Ahmet; Demiral, Gökhan; Samancı, Tuğba Çelik; Mercantepe, Tolga; Cüre, Medine Cumhur; Cüre, Erkan (Taylo & Francis Ltd., 2021)Objectives: Carbon tetrachloride (CCl4), employed in various industrial fields, can cause acute damage in renal tissues. This study investigated the therapeutic effect of the TNF-alpha inhibitor Infliximab on TGF-beta and ... -
The effects of white tea (Camellia Sinensis) and infliximab against cisplatin-induced testicular damage via oxidative stress and apoptosis
Çakıroğlu, Şenay; Mercantepe, Tolga; Tümkaya, Levent; Uydu, Hüseyin Avni; Topçu, Atilla; Atak, Mehtap (2023)Cisplatin (Cis) is an important chemotherapeutic agent used in cancer treatment. Males exposed to Cis were reported to exhibit testicular toxicity. Cis-induced testicular toxicity is mediated by oxidative stress, inflammation, ... -
The effects of whortleberry on ischemia reperfusion-induced myocardial injury in rats
Karakişi, Sedat Ozan; Hemşinli, Doğuş; Ergene, Şaban; Mercantepe, Tolga; Tümkaya, Levent; Yılmaz, Adnan (2020)Background: The aim of this study was to investigate the potential protective effect of whortleberry by examining the effects on heart tissue at the molecular level of ischemia-reperfusion injury caused by surgical repair ... -
Evaluation of the protective effect of coenzyme Q10 against x-ray irradiation-induced ovarian injury
Tekin, Yeşim Bayoğlu; Tümkaya, Levent; Mercantepe, Tolga; Topal, Zehra Suzan; Samancı, Tuğba Çelik; Yılmaz, Hülya Kılıç; Rakıcı, Sema Yılmaz; Topçu, Atilla (Wiley, 2024)Aim: This study focused on the anti-oxidant and anti-apoptotic effects of CoQ10 in ovaries exposed to pelvic radiation. Methods: Thirty-two female rats were randomly assigned into four groups. Group I (control group), Group ... -
Evaluation of the protective effects of amifostine and melatonin against cisplatin induced testis injury via oxidative stress and apoptosis in rats
Eren, Hüseyin; Mercantepe, Tolga; Tümkaya, Levent; Mercantepe, Filiz; Dil, Eyüp; Horsanali, Mustafa Ozan; Yılmaz, Adnan (Academic Press Inc Elsevier Science, 2020)..... -
Histopathological evaluation of the effects of dexmedetomidine against pituitary damage ınduced by X-ray irradiation
Mercantepe, Filiz; Tümkaya, Levent; Mercantepe, Tolga; Rakıcı, Sema (Taylor & Francis Ltd., 2022)Background: The present study, aimed to investigate the potential negative effects of x-ray radiation and the effects of the α2-adrenergic receptor agonist dexmedetomidine on the pituitary gland. Methods: Twenty-four ... -
The impact of apelin-13 on cisplatin-induced endocrine pancreas damage in rats: an in vivo study
Çiftel, Serpil; Tümkaya, Levent; Saral, Sinan; Mercantepe, Tolga; Akyıldız, Kerimali; Yılmaz, Adnan; Mercantepe, Tolga (Springer, 2024)Apelin-13 is a peptide hormone that regulates pancreatic endocrine functions, and its benefits on the endocrine pancreas are of interest. This study aims to investigate the potential protective effects of apelin-13 in ... -
Influences of periodontitis on hippocampal inflammation, oxidative stress, and apoptosis in rats
Köse, Oğuz; Altın, Ahmet; Bayrakdar, Sevda Kurt; Bostan, Semih Alperen; Mercantepe, Tolga; Akyıldız, Kerimali; Tümkaya, Levent; Yılmaz, Adnan; Köse, Sefanur; Yemenoğlu, Hatice; Şener, Leyla Türker; Göker, Kuluslu (Wiley, 2021)Background and aim The hippocampus, which has a central role in cognitive and behavioral activities, is one of the most sensitive parts of the brain to systemic inflammatory diseases. This animal study aims to comprehensively ... -
Inhibition of methotrexate induced toxicity in the adult rat spleen by adalimumab
Bahçeci, İlkay; Tümkaya, Levent; Mercantepe, Tolga; Aslan, Nuray; Duran, Ömer Faruk; Söztanacı, Umut Serkan; Yazıcı, Zihni Açar (Taylor & Francis Ltd., 2022)Methotrexate (MTX) has been in use for the treatment of rheumatoid arthritis (RA), psoriasis, and cancer since 1948. Its toxic side effects on tissues and organs have been well documented but splenotoxicity has not been ... -
An investigation of the effects of metformin on ovarian ischemia-reperfusion injury in rats
Topçu, Atilla; Balık, Gülşah; Atak, Mehtap; Mercantepe, Tolga; Uydu, Hüseyin Avni; Tümkaya, Levent (Elsevier, 2019)Damage to the ovaries or tissue torsion can significantly reduce the ovarian reserve and thus cause severe gynecological and hormonal deficiencies. the discovery of new agents is always needed in the treatment of this ... -
An investigation of the effects of N-acetylcysteine on radiotherapy-induced testicular injury in rats
Topçu, Atilla; Mercantepe, Filiz; Rakıcı, Sema; Tümkaya, Levent; Uydu, Hüseyin Avni; Mercantepe, Tolga (Springer, 2019)According to data issued by the International Agency for Research on Cancer in 2012, the estimated number of new cases of all types of cancer worldwide was estimated to exceed 10 million, and 6 million of whom receive ... -
Investigation of the effects of white tea on liver fibrosis: An experimental animal model
Yılmaz, Hülya Kılıç; Türker, Merve; Kutlu, Eda Yılmaz; Mercantepe, Tolga; Pınarbaş, Esra; Tümkaya, Levent; Atak, Mehtap (Wiley, 2024)Liver fibrosis is a common, progressive disease that affects millions of patients worldwide. In this study, it was aimed at investigating the effect of white tea on liver fibrosis in an in-vivo environment by creating an ... -
Less use of the bipolar cautery can prevent postlaminectomy epidural fibrosis: an experimental study in rats
AIM: To investigate the role of bipolar electrocautery in the occurrence of epidural fibrosis following lumbar spine laminectomy in a rat model. MATERIAL and METHODS: Fourteen male Sprague–Dawley rats (age: 4–6 months, ... -
Long-term protective effects of lamotrigine in a rat ovarian ischemia-reperfusion model
Aktepe, Rıza; Üçüncü, Yılmaz; Tümkaya, Levent; Mercantepe, Tolga; Topçu, Atilla; Uydu, Hüseyin Avni; Atak, Mehtap (Elsevier, 2024)Ovarium torsion is a gynecological emergency that is common in women of reproductive age and requires early diagnosis and intervention. In this study, we aimed to investigate the long-term anatomical, histological and ...