Yazar "Çetin, Nihal" için listeleme
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Biochemically and histopathologically comparative review of thiamine's and thiamine pyrophosphate's oxidative stress effects generated with methotrexate in rat liver
Demiryılmaz, İsmail; Şener, Ebru; Çetin, Nihal; Altuner, Durdu; Süleyman, Bahadır; Albayrak, Fatih; Akçay, Fatih (2012)Background: Oxidative liver injury occurring with methotrexate restricts its use in the desired dose. Therefore, whether or not thiamine and thiamine pyrophosphate, whose antioxidant activity is known, have protective ... -
Can thiamine pyrophosphate prevent desflurane induced hepatotoxicity in rats?
Arslan, Aynur; Kuyrukluyıldız, Ufuk; Binici, Orhan; Çetin, Nihal; Balcı, Mecdi Gürhan; Kuzucu, Mehmet; Yılmaz, Adnan; Altuner, Durdu; Çoban, Taha Abdülkadir (Acta Cirurgica Brasileira, 2016)PURPOSE: To investigate the effects of thiamine pyrophosphate (TPP) against desflurane induced hepatotoxicity. METHODS: Thirty experimental animals were divided into groups as healthy (HG), desflurane control (DCG), TPP ... -
Chondroprotective effects of a new glucosamine combination in rats: Gene expression, biochemical and histopathological evaluation
Üçüncü, Yılmaz; Çelik, Nuray; Öztürk, Cengiz; Türkoğlu, Murat; Çetin, Nihal; Koçkara, Nizamettin; Şener, Ebru; Dündar, Cihat; Arslan, Aynur; Doğan, Hasan; Kurt, Nezahat; Süleyman, Halis (Pergamon-Elsevier Science Ltd, 2015)Aims: This study investigates the effect of a new combination of glucosamine hydrochloride, chondroitin sulfate, methylsulfonylmethane, Harpagophytum procumbens root extract (standardized to 3% harpagoside) and bromelain ... -
A comparative investigation of biochemical and histopathological effects of thiamine and thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat ovarian tissue
Demiryılmaz, İsmail; Şener, Ebru; Çetin, Nihal; Altuner, Durdu; Akçay, Fatih; Süleyman, Halis (Pharmaceutical Soc Korea, 2013)In this study, the biochemical and histopathological effects of thiamine and thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat ovarian tissue were investigated. Animals were divided into four ... -
Comparative review of biochemistry and cell anatomy of the hepatic tissue in rats administered some anti hypertensive drug for a long time
Malkoç, İsmail; Çetin, Nihal; Altuner, Durdu; Hacımüftüoğlu, Ahmet; Gürsan, Nesrin; Bakan, Ebubekir; Akçay, Fatih; Süleyman, Halis (2012)The adverse biochemical and structural effects of antihypertensive drugs over a long period (clonidine, methyldopa, rilmenidine, amlodipine, ramipril) on hepatic tissue has been examined in this study. The results are ... -
Controlled reperfusion for different durations in the treatment of ischemia-reperfusion injury of the rat ovary: evaluation of biochemical features, molecular gene expression, and histopathology
Yapca, Ömer Erkan; Kumbasar, Serkan; Salman, Süleyman; Yaralı, Oğuzhan; Şener, Ebru; Mammadov, Renad; Tekin, Yeşim Bayoğlu; Aksoy, Ayşenur; Albayrak, Abdulmecit; Çetin, Nihal (Canadian Science Publishing, Nrc Research Press, 2015)High numbers of proinflammatory cells (PMNLs), which are carried by the blood to ischemic tissue during reperfusion, are considered responsible for inducing the inflammatory response that occurs in ischemia-reperfusion ... -
Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats
Mammadov, Renad; Süleyman, Bahadır; Altuner, Durdu; Demirci, Elif; Çetin, Nihal; Yılmaz, Adnan; Baykal, Hüseyin; Alpcan, Hilal; Turumtay, Emine Akyüz; Süleyman, Halis (Acta Cirurgica Brasileira, 2019)Purpose: To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG). Methods: the anticancer ... -
The effect of hippophae rhamnoides extract on oxidative damage on rat's gastric tissue depending on Co-implementation of methotrexate and indomethacin
Yılmaz, İsmayıl; Demiryılmaz, İsmail; Şener, Ebru; Çetin, Nihal; Üçüncü, Yılmaz; Altuner, Durdu; Kurt, Nezahat; Kunak, Semih C.; Kısaoğlu, Abdullah; Özoğul, Bünyamin; Süleyman, Halis (Colegio Farmaceuticos Provincia de Buenos Aires, 2014)The effect of Hippophae rhamnoides (HR) extract on oxidative damage on rat's gastric tissue depending on co-implementation of methotrexate (MTX) and indomethacin (IND) was investigated biochemically and histopathologically. ... -
The effect of mirtazapine on cisplatin-induced oxidative damage and infertility in rat ovaries
Altuner, Durdu; Gülaboğlu, Mine; Yapca, Ömer Erkan; Çetin, Nihal (Hindawi Ltd, 2013)Cisplatin causes infertility due to ovarian toxicity. the toxicity mechanism is unknown, but evidence suggests oxidative stress. in this study, the effect of mirtazapine on cisplatin-induced infertility and oxidative stress ... -
Effect of mirtazapine on gastric oxidative stress and DNA injury created with methotrexate in rats
Demiryılmaz, İsmail; Uzkeser, Hülya; Çetin, Nihal; Hacımüftüoğlu, Ahmet; Bakan, Ebubekir; Altuner, Durdu (Chemical Publishing Co., 2013)In this study, effect of mirtazapine on gastric oxidative stress and DNA injury created with methotrexate was investigated. Experimental results showed that GSH (nmol/g protein), MDA (?mol/g protein) and MPO (?/g protein) ... -
The effect of mirtazapine on methotrexate-induced toxicity in rat liver
Özoğul, Bünyamin; Kısaoğlu, Abdullah; Turan, Mehmet Ibrahim; Altuner, Durdu; Sener, Ebru; Çetin, Nihal; Öztürk, Cengiz (Science Society Thailand, 2013)Methotrexate is used as a chemotherapeutic agent and its anti-oxidant activity is used to treat many cancer types. This study conducts a biochemical and histopathological investigation into whether mirtazapine has a ... -
Effect of thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat kidney
Altuner, Durdu; Çetin, Nihal; Süleyman, Bahadır; Aslan, Zeynep; Hacımuftuoğlu, Ahmet; Gülaboğlu, Mine; İsaoğlu, Neslihan; Demiryılmaz, İsmail; Suleyman, Halis (Wolters Kluwer Medknow Publications, 2013)Objectives: the biochemical effects of thiamine pyrophosphate on ischemia-reperfusion (IR) induced oxidative damage and DNA mutation in rat kidney tissue were investigated, and compared to thiamine. Materials and Methods: ... -
Effects of hippophae rhamnoides extract on oxidative mucosal injury induced by cisplatin in rat jejunum
Arslan, Aynur; Özçiçek, Fatih; Çimen, Ferda Keskin; Nalkıran, Hatice Sevim; Gülaboğlu, Mine; Çetin, Nihal; Çoban, Taha Abdulkadir; Kuzucu, Mehmet (Scientific Publishers of India, 2018)Objectives: We aimed to assess the effect of Hippophae rhamnoides extract (HR) on oxidative stress induced by cisplatin (Cis) in rat small intestine tissue by evaluating the biochemical and gene expression levels and ... -
Effects of nimesulide on oxidative mucosal injury induced by cisplatin in rat duodenum and jejunum
Özçiçek, Fatih; Çankaya, Murat; Çimen, Ferda K.; Kafa, Ayşe H. T.; Nalkıran, Hatice Sevim; Süleyman, Bahadır; Altuner, Durdu; Çetin, Nihal (Colegio Farmaceuticos Provincia de Buenos Aires, 2016)In this study, the impact of nimesulide on oxidative stress induced by cisplatin in rat duodenum and jejunum tissue was assessed by evaluating the biochemical and histopathological changes. the rats in the study were ... -
Effects of nimesulide on the small intestine mucositis induced by methotrexate in rats
Arslan, Aynur; Özçiçek, Adalet; Süleyman, Bahadır; Çoban, Taha Abdulkadir; Çimen, Ferda Keskin; Nalkıran, Hatice Sevim; Kuzucu, Mehmet; Altuner, Durdu; Çetin, Nihal; Süleyman, Halis (Int Press Editing Centre Inc, 2016)Intestinal mucositis is one of the major problems in the patients receiving cancer treatment. Nimesulide is a drug with antioxidant, antiinflammatory and antiulcer features. We aimed to investigate the effect of nimesulide ... -
The effects of thiamine and thiamine pyrophosphate on alcohol-induced hepatic damage biomarkers in rats
Yılmaz, İsmayil; Demiryılmaz, İsmail; Turan, Mehmet İbrahim; Çetin, Nihal; Gül, Mehmet Ali; Süleyman, Halis (Verduci Publisher, 2015)OBJECTIVE: This study examined the effects of thiamine and thiamine pyrophosphate on oxidative damage developing in association with hepatic injury caused by alcohol toxicity in rats and on hepatic injury markers. MATERIALS ... -
Effects of thiamine and thiamine pyrophosphate on epileptic episode model established with caffeine in rats
Turan, Mehmet İbrahim; Tan, Hüseyin; Çetin, Nihal; Süleyman, Halis; Çayır, Atilla (Elsevier, 2014)This study examines the effect of thiamine (TH) and thiamine pyrophosphate (TPP) on epileptic episode model induced in rats with caffeine. Animals were divided into groups and given TH or TPP at doses of 10, 30 or 50 mg/kg ... -
Exogenous ATP administration prevents ischemia/reperfusion-induced oxidative stress and tissue injury by modulation of hypoxanthine metabolic pathway in rat ovary
Kumbasar, Serkan; Çetin, Nihal; Yapca, Ömer Erkan; Şener, Ebru; İsaoğlu, Ünal; Yılmaz, Mehmet; Salman, Süleyman; Aksoy, Ayşe Nur; Gül, Mehmet Ali; Süleyman, Halis (Univ Federal Santa Maria, 2014)In this study, xanthine oxidase (XO), malondialdehyde (MDA), myeloperoxidase (MPO) and glutathione (GSH) levels in the ovarian tissues of rats during the development of ischemia and postischemia-induced reperfusion were ... -
Gene expression and histopathological evaluation of thiamine pyrophosphate on optic neuropathy induced with ethambutol in rats
Çinici, Emile; Çetin, Nihal; Süleyman, Bahadır; Altuner, Durdu; Yaralı, Oğuzhan; Balta, Hilal; Çalık, İlknur; Tümkaya, Levent; Süleyman, Halis (Ijo Press, 2016)AIM: To compare the effects of thiamine pyrophosphate (TPP) and thiamine (TM) in oxidative optic neuropathy in rats induced by ethambutol. METHODS: the animals were divided into four groups: a control group (CG), an ...
