Yazar "Öztürk, Seda Duman" için listeleme
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Does apoptotic index predict the response to neoadjuvant chemotherapy in patients with breast carcinoma?
Askan, Gökçe; Okcu, Oğuzhan; Öztürk, Çiğdem; Öztürk, Seda Duman; Şen, Bayram; Bedir, Recep (Galenos Publishing, 2023)Objective: Neoadjuvant chemotherapy (NACT) plays a major role in the treatment of patients with locally advanced breast carcinoma. Although most patients have benefited from NACT, the rate of residual tumors is still high ... -
The effects of amiodarone in ovarian injury due to oxidative stress and inflammation caused by ischemia-reperfusion
Topçu, Atilla; Öztürk, Aykut; Deniz, Esra; Öztürk, Seda Duman; Arpa, Medeni; Atak, Mehtap (Taylor & Francis Ltd., 2022)Objective Ovarian ischemia constitutes 2-3% of all gynecological emergencies. New-generation therapeutic agents need to be discovered, in addition to invasive interventions capable of reducing the risk of potential ovarian ... -
The effects of vitamin B12 on the TLR-4/NF-κB signaling pathway in ovarian ischemia-reperfusion injury-related inflammation
Deniz, Esra; Topçu, Atilla; Öztürk, Aykut; Öztürk, Seda Duman; Arpa, Medeni; Atak, Mehtap (Elsevier, 2022)Ovarian ischemia is a gynecological emergency case that occurs as a result of ovarian torsion. Oxidative stress and inflammation play central roles in the development of ischemia/reperfusion injuries. We investigated the ... -
High tumor infiltrating lymphocytes are associated with overall survival and good prognostic parameters in endometrial endometrioid carcinoma patients
Öztürk, Çiğdem; Askan, Gökçe; Öztürk, Seda Duman; Okcu, Oğuzhan; Şen, Bayram; Bedir, Recep (Federation Turkish Pathology Soc., 2023)Objective: The mortality incidence of endometrial carcinomas (ECs) has increased in recent years. Therefore, recent studies have focused on the cellular and microenvironmental properties of ECs. Tumor-infiltrating lymphocytes ... -
A new practical method of estimating tumoral microenvironment parameters of possible prognostic significance in patients with invasive breast carcinoma: Combined microenvironment score
Öztürk, Çiğdem; Okcu, Oğuzhan; Öztürk, Seda Duman; Askan, Gökçe; Şen, Bayram; Bedir, Recep (Elsevier, 2023)Background and objective: In recent years, the tumor microenvironment has become increasingly recognized as an influential factor in breast cancer development and growth. The parameters that form the microenvironment are ... -
Nucleolus assessment in invasive breast carcinoma, an objective parameter for histological grading
Öztürk, Seda Duman; Öztürk, Çiğdem; Okcu, Oğuzhan; Şen, Bayram; Bedir, Recep (TUBİTAK Scientific & Technical Research Council Turkey, 2022)Background/aim: The nucleolus has the potential to provide insight into how many types of cancer will progress. In this study, we examined the evaluation of the nucleolus with a microscope in widespread breast cancer tumors ... -
Predicting response to neoadjuvant therapy with glucose transporter-1 in breast cancer
Öztürk, Seda Duman; Öztürk, Çiğdem; Okcu, Oğuzhan; Askan, Gökçe; Şen, Bayram; Bedir, Recep (Assoc Medica Brasileira, 2023)OBJECTIVE: Glucose transporter-1 is a marker involved in energy transport in cancer cells. It has been shown to be a poor prognostic factor in many cancer types, including breast cancer. However, there is no satisfactory ... -
Prognositc significance of microcystic elongated and fragmanted (MELF) myometrial ınvasion pattern: A retrospective study
Okcu, Oğuzhan; Askan, Gökçe; Şen, Bayram; Öztürk, Çiğdem; Öztürk, Seda Duman; Güvendi, Gülname Fındık (2022)Objective: Endometrioid endometrial carcinomas (EEC) are the most commonly diagnosed malignancies of the female genital tract. Myometrial invasion depth is one of the most significant pathological prognostic parameters. ... -
The prognostic significance of non-lymphoid immune cells of the tumor microenvironment, including neutrophils, eosinophils, and mast cells in breast carcinomas
Okcu, Oğuzhan; Öztürk, Çiğdem; Şen, Bayram; Ayazoğlu, Muhammet Safa; Güvendi, Gülname Fındık; Öztürk, Seda Duman; Askan, Gökçe; Bedir, Recep (Elsevier, 2023)Background and objective: The prognostic importance of lymphoid cells in the tumor microenvironment and their effect on treatment response have been demonstrated in many cancer types. However, there are limited studies on ... -
The protective effects of trimetazidine against ovary ischemia-reperfusion injury via the TLR4/Nf-kB signal pathway
Öztürk, Aykut; Topçu, Atilla; Deniz, Esra; Öztürk, Seda Duman; Arpa, Medeni; Yılmaz, Eda Kutlu (Wiley, 2022)Late diagnosis and treatment of ovarian ischemia can lead to worsening of ischemia, irreversible damage to ovarian functions and infertility. In this process, there is no approved medical treatment that can reduce the ... -
Reporting hormone receptor expression in breast carcinomas: which method has the highest prognostic power and what should be the optimal cut-off value?
Öztürk, Çiğdem; Okcu, Oğuzhan; Öztürk, Seda Duman; Şen, Bayram; Öztürk, Ahmet Emin; Bedir, Recep (Sage Publications, 2024)Background . Hormone receptor (HR) expression is a critical marker that plays a role in the treatment and management of breast cancer. Even if patients receive hormone treatment with a hormone positivity rate of over 1%, ... -
Response to letter to the editor
Okcu, Oğuzhan; Öztürk, Çiğdem; Şen, Bayram; Ayazoğlu, Safa; Güvendi, Gülname Fındık; Öztürk, Seda Duman; Askan, Gökçe; Bedir, Recep (Elsevier, 2023)We would like to thank Dr. Altındağ for his interest in our publication (Prognostic significance of non-lymphoid immune cells of the tumor microenvironment, including neutrophils, eosinophils, and mast cells in breast ... -
Tumor budding is an independent prognostic factor to predict overall survival in endometrial endometrioid carcinoma: A retrospective study
Okcu, Oğuzhan; Şen, Bayram; Askan, Gökçe; Öztürk, Çiğdem; Öztürk, Seda Duman; Bedir, Recep (Sage Publications, 2022)Objective. Tumor budding defined as a tumor cell nest away from the main tumor, has been found to be associated with prognostic parameters in many cancer types. We aimed to investigate the relationship between tumor budding ... -
Tumor-infiltrating lymphocytes (TILs)/volume and prognosis: The value of TILs for survival in HER2 and TN breast cancer patients treated with chemotherapy
Okcu, Oğuzhan; Öztürk, Seda Duman; Öztürk, Çiğdem; Şen, Bayram; Yasin, Ayşe İrem; Bedir, Recep (Elsevier, 2022)Background and objective: The use of the tumor microenvironment as a target in creating treatment modalities and as a biomarker in predicting treatment response has become increasingly important. Tumor-infiltrating ... -
Tumor-infiltrating lymphocytes may predict prognosis in breast cancer patients receiving neoadjuvant chemotherapy
Objective: Investigation of the histopathological features in core biopsies can predict the chemotherapy responses and thus provide information about the prognosis of breast cancer patients. Tumor-infiltrating lymphocytes ...
