Yazar "Ülker, Serdar" için listeleme
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Cloning, expression, and characterization of a novel CTP synthase gene from Anoxybacillus gonensis G2
Sandallı, Cemal; Saral, Ayşegül; Ülker, Serdar; Karaoğlu, Hakan; Beldüz, Ali Osman; Çiçek, Ayşegül Çopur (2014)The cytidine-5'-triphosphate (CTP) synthase (EC 6.4.3.2) gene (pyrG) was cloned and sequenced from the thermophilic bacterium Anoxybacillus gonensis G2 (Ago). The gene is 1590 bp in length and encodes a protein of 530 amino ... -
Cloning, purification and characterization of acetyl Xylane esterase from anoxybacillus flavithermus DSM 2641(T) with activity on low molecular-weight acetates
Eminoğlu, Ayşenur; Ülker, Serdar; Sandallı, Cemal (Springer, 2015)Family 4 carbohydrate esterases (CE-4) have deacetylate different forms of acetylated poly/oligosaccharides in nature. This family is recognized with a specific polysaccharide deacetylase domain assigned as NodB homology ... -
Conventional and microwave irradiated synthesis, biological activity evaluation and molecular docking studies of highly substituted piperazine-azole hybrids
Mermer, Arif; Demirci, Serpil; Özdemir, Serap Başoğlu; Demirbaş, Ahmet; Ülker, Serdar; Ayaz, Faik Ahmet; Demirbaş, Neslihan (Elsevier Science Inc, 2017)Azole derivatives (3, 6) obtained starting from 1-(2-methoxyphenyl)piperazine were converted to the corresponding Mannich bases containing beta-lactame or flouroquinolone core via a one pot three component reaction. the ... -
Design, synthesis and biological activities of some 7-aminocephalosporanic acid derivatives
Başoğlu, Serap; Demirbaş, Ahmet; Ülker, Serdar; Alpay-Karaoğlu, Şengül; Demirbaş, Neslihan (Elsevier France-Editions Scientifiques Medicales Elsevier, 2013)The treatment of 7-ACA with 4-substituted benzensulfonyl chlorides afforded the compounds containing 4-nitro/aminophenyl sulfonylamino moiety in the cephalosporanic acid skeleton (2, 4). the synthesis of the cephalosporanic ... -
Design, synthesis, and biological evaluation of coumarin-triazole hybrid molecules as potential antitumor and pancreatic lipase agents
Kahveci, Bahittin; Yılmaz, Fatih; Menteşe, Emre; Ülker, Serdar (Wiley-V C H Verlag Gmbh, 2017)The design, synthesis, and investigation of antitumor and anti-lipase activities of some coumarin-triazole hybrid molecules are reported. the synthesis of these hybrid molecules was performed under microwave irradiation ... -
An efficient synthesis of benzimidazoles via a microwave technique and evaluation of their biological activities
Kahveci, Bahittin; Menteşe, Emre; Özil, Musa; Ülker, Serdar; Ertürk, Murat (Springer Wien, 2013)A simple and practical protocol was developed for the synthesis of benzimidazoles. the protocol uses iminoester hydrochloride which is very useful in the reaction with 4,5-dichloro-1,2-phenylenediamine under microwave ... -
Isolation, production, and characterization of an extracellular lipase from Trichoderma harzianum isolated from soil
Bu çalışma, Trichoderma harzianum lipazının karakterizasyonu hakkında ilk rapordur. Yeni bir suş olan Trichoderma harzianum IDM14D topraktan izole edildi. İzole edilen bu suş, lipaz üretimi için çalkalamalı kültürde 30 ... -
Microwave assisted synthesis and anti-lipase activity of some new fluorine-containing benzimidazoles
Menteşe, Emre; Yılmaz, Fatih; Ülker, Serdar; Kahveci, Bahittin (Georg Thieme Verlag Kg, 2015)In this study, a new series of fluorine containing benzimidazoles (4a-l) and bisbenzimidazoles (6a-c, 8) were synthesized by the reaction of o-phenylenediamines with iminoester hydrochlorides (3a-l, 7) in methanol under ... -
Microwave assisted synthesis and antimicrobial activity evaluation of new heterofunctionalized norfloxacine derivatives
Menteşe, Meltem; Demirci, Serpil; Özdemir, Serap B.; Demirbaş, Ahmet; Ülker, Serdar; Demirbaş, Neslihan (Bentham Science Publ Ltd, 2016)The synthesis of new hybrid compounds containing several heterocyclic groups namely norfloxacine, 1,2,4-triazole, 1,3,4-oxadiazole, piperazine, morpholine, thiomorpholine, 1,3,4-thiadiazole etc. was performed by conventional ... -
Microwave assisted synthesis of some hybrid molecules derived from norfloxacin and investigation of their biological activities
Menteşe, Meltem Yolal; Bayrak, Hacer; Uygun, Yıldız; Mermer, Arif; Ülker, Serdar; Karaoğlu, Şengül Alpay; Demirbaş, Neslihan (Elsevier France-Editions Scientifiques Medicales Elsevier, 2013)Norfloxacin was converted to 7-(4-amino-2-fluorophenyl)piperazin derivative (2) via the formation of nitro compound. the synthesis of the norfloxacin derivatives containing 1,3-thiazole or 1,3-thiazolidin moiety was performed ... -
Microwave-assisted and conventional synthesis of novel antimicrobial 1,2,4-triazole derivatives containing nalidixic acid skeleton
Ceylan, Şule; Bayrak, Hacer; ÖZdemir, Serap Başoğlu; Uygun, Yıldız; Mermer, Arif; Demirbaş, Neslihan; Ülker, Serdar (Walter de Gruyter Gmbh, 2016)Carbothioamides 4a,b, obtained from nalidixic acid, were converted to the corresponding 1,3-thiazolidine derivatives 5a,b by cyclocondensation with 2-bromo-1-(4-chlorophenyl) ethanone. Treatment of 4a,b with base afforded ... -
Microwave-assisted synthesis and biological evaluation of some benzimidazole derivatives containing a 1,2,4-triazol ring
Menteşe, Emre; Karaali, Nesrin; Yılmaz, Fatih; Ülker, Serdar; Kahveci, Bahittin (Wiley-V C H Verlag Gmbh, 2013)A new series of 2-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole derivatives containing a 1,2,4-triazole ring were synthesized via microwave technique. This efficient procedure provides pure products within a few minutes. ... -
Microwave-assisted synthesis of new benzimidazole derivatives with lipase inhibition activity
Menteşe, Emre; Bektaş, Hakan; Ülker, Serdar; Bekircan, Olcay; Kahveci, Bahittin (Taylor & Francis Ltd, 2014)A practical protocol has been used for the synthesis of benzimidazoles. the reaction of iminoester hydrochlorides of phenylacetic with 4,5-dichloro-1,2-phenylenediamine under microwave irradiation leads to the benzimidazole ... -
Microwave-assisted synthesis of some hybrid molecules containing penicillanic acid or cephalosporanic acid moieties and investigation of their biological activities
Başoğlu, Serap; Ülker, Serdar; Alpay-Karaoğlu, Şengül; Demirbaş, Neslihan (Springer Birkhauser, 2014)Ethyl 4-amino-2-fluorophenylpiperazin-1-carboxylates containing a 1,3-oxazol(idin)e, 5-thioxo-1,2,4-triazole, 1,3,4-thiadiazole, 5-thioxo-1,3,4-oxadiazole, or 1,3-thiazole nucleus were obtained starting from ethyl ... -
Microwave-assisted synthesis of some new coumarin derivatives including 1,2,4-triazol-3-one and investigation of their biological activities
Kahveci, Bahittin; Yılmaz, Fatih; Menteşe, Emre; Ülker, Serdar (Springer, 2015)By using the microwave technology, a new protocol has been developed for the synthesis of new coumarin derivatives including 1,2,4-triazol-3-one skeleton. This protocol proves to be efficient and environmentally friendly ... -
Microwave-promoted synthesis and biological activity of some 2-hetarylmethyl-4-(4-hetarylphenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one derivatives
Özil, Musa; Bodur, Osman; Ülker, Serdar; Kahveci, Bahittin (Springer, 2015)A series of fused and non-fused 1,2,4-triazole derivatives were prepared starting from ethyl 4-[1-(2-ethoxy-2-oxoethyl)-3-methyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]benzoate. Firstly, both ethyl ester groups were ... -
Molecular docking studies and synthesis of novel bisbenzimidazole derivatives as inhibitors of alpha-glucosidase
Özil, Musa; Emirik, Mustafa; Beldüz, Ali; Ülker, Serdar (Pergamon-Elsevier Science Ltd, 2016)A series of bisbenzimidazole derivatives starting from o-phenylenediamine and 4-nitro-o-phenylenediamine were prepared with oxalic acid. Most of the reactions were conducted using both the microwave and conventional methods ... -
New lipase assay using Pomegranate oil coating in microtiter plates
Ülker, Serdar; Placidi, Camille; Point, Vanessa; Gadenne, Benoit; Serveau-Avesque, Carole; Canaan, Stephane; Corriere, Frederic; Cavalier, Jean-Francois (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)Lipases play various roles in fat digestion, lipoprotein metabolism, and in the mobilization of fat stored in lipid bodies in animals, plants and microorganisms. in association with these physiological functions, there is ... -
Novel microwave assisted synthesis and antimicrobial activity of new quinolone-hybrids
Ceylan, Şule; Bayrak, Hacer; Özdemir, Serap Başoğlu; Uygun, Yıldız; Mermer, Arif; Demirbaş, Neslihan; Ülker, Serdar (Bentham Science Publ Ltd, 2016)Background: Carbo(thio)amid derivatives 4a, 4b were obtained starting from nalidixic acid in three steps. the acidic treatment of compound 4a generated the corresponding 1,3,4-oxadiazole (5), while the compound 4a gave ... -
Purification and characterization of an extracellular lipase from Mucor hiemalis f. corticola isolated from soil
Ülker, Serdar; Karaoğlu, Şengül Alpay (Elsevier, 2012)We have screened 39 microfungi isolates originated from soil in terms of lipolytic activity. Out of all screened, a novel strain of Mucor hiemalis f. corticola was determined to have the highest lipase activity. The ...
