Yazar "Akyüz, Gülay" için listeleme
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Benzimidazolone-piperazine/triazole/thiadiazole/furan/thiophene conjugates: Synthesis, in vitro urease inhibition, and in silico molecular docking studies
Güven, Okan; Menteşe, Emre; Emirik, Mustafa; Sökmen, Bahar Bilgin; Akyüz, Gülay (Wiley, 2023)This study describes the synthesis, in vitro urease inhibition, and molecular docking studies of benzimidazolone derivatives incorporating the piperazine, triazole, thiadiazole, furan, thiophene, and thiosemicarbazide ... -
Characterization and inhibition studies of carbonic anhydrase from gill of Russian Sturgeon Fish (Acipenser gueldenstaedtii)
Dincer, Barbaros; Ekinci, Arife Pınar; Akyüz, Gülay; Kurtoğlu, İlker Zeki (Taylor & Francis Ltd, 2016)An alpha-carbonic anhydrase (CA, EC 4.2.1.1) was purified and characterized kinetically from gill of Acipenser gueldenstaedtii as an endangered sturgeon species. the carbonic anhydrase was purified 66-folds with yield 20.7% ... -
A facile ultrasonic synthesis approach to 3-H-quinazolinethione derivatives and their urease inhibition studies
Çalışkan, Nedime; Akyüz, Gülay; Menteşe, Emre (Taylor & Francis Ltd., 2024)In this study, a new series of 3H-quinazoline-4-thione derivatives were synthesized under ultrasonic irradiation conditions with high yield in a short time. The new compounds were characterized by FT-IR,H-1, and C-13 NMR ... -
Microwave-assisted synthesis of some benzimidazole derivatives containing imine function
Akyüz, Gülay; Yılmaz, Fatih; Menteşe, Emre (2015)Benzimidazol modern ilaç keşfinde önemli bir farmakofordur. Birçok benzimidazole türevi yeni ilaç adayı bileşikler elde etmek amacıyla organik kimyacılar tarafından sentezlenmektedir. Bu çalışmada, imin fonksiyonu içeren ... -
Synthesis and biological evaluation of coumarin-amino acid-benzotriazole conjugates
Menteşe, Emre; Çalışkan, Nedime; Sökmen, Bahar Bilgin; Akyüz, Gülay (Springer, 2024)Objective: It is aimed to synthesize new amino acid-conjugated coumarin-benzotriazole molecules and to investigate their acetylcholinesterase, urease, and lipase inhibition properties. Methods: Urease inhibitory activities ... -
Synthesis and characterization of new bistriazole quinazolinediones and their urease inhibition activities
Akyüz, Gülay; Menteşe, Emre (Bentham Science Publications, 2023)A new series of bisthiosemicarbazide and bistriazole molecules bridged quinazolinedione was synthesized and characterized by FT-IR, H-1 and C-13-NMR spectral data. Antiurease activities of all new compounds were tested ... -
Synthesis and characterization of some new 2,3-disubstituted quinazolin-4(3h)-one compounds, investigation of urease, and ache inhibition properties, molecular, and docking study
Karaali, Nesrin Ünal; Akyüz, Gülay; Emirik, Mustafa (Springer, 2024)Objective: Novel 2,3-disubstituted 4-oxoquinazoline-3(4H) derivatives containing oxadiazole, thiazolidinone ring, the 4-oxoquinazoline-3(4H) Schiff bases, and carbothioamide structure were synthesized. All the synthesized ... -
Synthesis and docking studies of novel benzimidazole derivatives containing thiophene and triazole rings as potential urease inhibitors
Akyüz, Gülay; Emirik, Mustafa; Sökmen, B.B.; Menteşe, Emre (Springer, 2022)Abstract: A new series of 5,6-dichloro-benzimidazoles containing thiophene ring derivatives of thiosemicarbazides and triazoles were designed, synthesized and characterized by spectral methods like as IR, 1H-NMR, 13C-NMR ... -
Synthesis and evaluation of alpha-glucosidase and pancreatic lipase inhibition by quinazolinone-coumarin hybrids
Menteşe, Emre; Karaali, Nesrin; Akyüz, Gülay; Yılmaz, Fatih; Ülker, Serdar; Kahveci, Bahittin (Springer, 2016)A new series of 2-substituted quinazolin-4(3H)-one derivatives including coumarin nucleus has been synthesized and screened for their lipase and a-glucosidase inhibition properties. Among the synthesized compounds, ... -
Synthesis and molecular docking study of some novel 2,3-disubstituted quinazolin-4(3H)-one derivatives as potent inhibitors of urease
Akyüz, Gülay; Menteşe, Emre; Emirik, Mustafa; Baltaş, Nimet (Academic Press Inc Elsevier Science, 2018)A new series of 2,3-disubstituted quinazolin-4(3H)-one compounds including oxadiazole and furan rings was synthesized. Their inhibitory activities on urease were assessed in vitro. All newly synthesized compounds exhibited ... -
Synthesis and urease inhibition activities of some new schiff bases benzimidazoles containing thiophene ring
Akyüz, Gülay (Springer, 2024)Objective: Schiff bases are significant pharmacophores and show varied biological applications such as antiurease, antidiabetic, antioxidant, antifungal, antibacterial, and anticancer. In this study, new Schiff bases ... -
Synthesis and urease inhibition studies of some new quinazolinones
Akyüz, Gülay (Wiley, 2021)In this study, novel quinazolinones were designed, synthesized, characterized by FT-IR, H-1-NMR, C-13-NMR spectral data, and LC-MS. New compounds inhibitory activities on urease were assessed. All of the compounds exhibited ... -
Synthesis of Benzimidazole derivatives containing Schiff base exhibiting antiurease activities
Akyüz, Gülay (Sivas Cumhuriyet Üniversitesi, 2021)In this study some novel Schiff bases derivatives of benzimidazole containing thiophene ring were designed and synthesized by using various aldehydes. Seven different aromatic aldehydes with various side groups were used ... -
Synthesis of new coumarin-C-3 benzimidazole hybrids and their urease inhibition studies
Akyüz, Gülay; Menteşe, Emre (Bentham Science Publications, 2023)A novel series of coumarin-benzimidazole hybrids were designed, synthesized, and extensively characterized using spectral data, including FT-IR, H-1-NMR, and C-13-NMR. Weatherburn's method was used to test new compounds' ... -
Synthesis of novel 2,3-disubstituted quinazolin-4(3H)-one derivatives containing hydrazone skeleton as potent urease inhibitors and their antimicrobial activities
Akyüz, Gülay; Beriş, Fatih Şaban; Kahveci, Bahittin; Menteşe, Emre (Wiley, 2019)A new series of quinazolinones containing hydrazone moiety were synthesized, and their inhibitory activities on urease were assessed in vitro. Most of the compounds exhibited potent urease inhibitory activity. Among the ... -
Synthesis of novel quinazolinone-triheterocyclic hybrides as dual inhibition of urease and ache
Menteşe, Emre; Güzel, Yeter Ünal; Akyüz, Gülay; Karaali, Nesrin Ünal (Springer, 2024)New triheteroyclic compounds containing quinazolinone, thiophene, andthiadiazole /thiazolidinone structureswere synthesized and characterized by FT-IR, 1H–NMR, and13C–NMRspectral data. The new compounds’ inhibitory activities ... -
Synthesis of some novel quinazolin-4(3H)-one hybrid molecules as potent urease inhibitors
Menteşe, Emre; Akyüz, Gülay; Yılmaz, Fatih; Baltaş, Nimet; Emirik, Mustafa (Wiley-V C H Verlag Gmbh, 2018)A new series of quinazolinone hybrid molecules containing coumarin, furan, 1,2,4-triazole and 1,2,4-thiadiazole rings was designed, synthesized, and screened for their urease inhibition activities. All newly synthesized ... -
Synthesis, in vitro urease inhibition and molecular docking studies of some novel quinazolin-4(3H)-one derivatives containing triazole, thiadiazole and thiosemicarbazide functionalities
Menteşe, Emre; Akyüz, Gülay; Emirik, Mustafa; Baltaş, Nimet (Academic Press Inc Elsevier Science, 2019)A new series of quinazolinone derivatives containing triazole, thiadiazole, thiosemicarbazide functionalities was synthesized and then screened for their in vitro urease inhibition properties. Most of the compounds showed ... -
Urease inhibition activity studies of novel azabenzimidazole-derived compounds
Akyüz, Gülay; Menteşe, Emre (Springer, 2024)AbstractA new series of azabenzimidazole compounds was synthesized and characterized with spectral methods such as IR, 1H NMR, 13C NMR and elemental analysis. The target compounds were screened for urease, and acetylcholinesterase ... -
Urease inhibition studies of new benzimidazoles containing triazole ring
Akyüz, Gülay; Menteşe, Emre; Kahveci, Bahittin (Maik Nauka/Interperiodica/Springer, 2023)A new series of benzimidazoles including triazole and thiosemicarbazide moieties was synthesized and their urease inhibition studies were evaluated according to the method of Van Slyke and Archibald. Especially triazole ...
