Yazar "Ayazoğlu Demir, Elif" için listeleme
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Alleviating effect of alpha-pinene on testicular torsion and detorsion injury in rats
Demir, Selim; Kazaz, İlke Onur; Sağnak Yılmaz, Zeynep; Türkmen Alemdar, Nihal; Ayazoğlu Demir, Elif; Tepe, Recep Serhat; Menteşe, Ahmet (Galenos Yayınevi, 2023)Objective: It was aimed to evaluate whether alpha-pinene (AP) had a beneficial effect in the testicular ischemia/reperfusion injury (IRI) model for the first time. Materials and Methods: Testicular malondialdehyde, total ... -
Alpha-pinene neutralizes cisplatin-induced reproductive toxicity in male rats through activation of Nrf2 pathway
Demir, Selim; Menteşe, Ahmet; Türkmen Usta, Zeynep; Türkmen Alemdar, Nihal; Ayazoğlu Demir, Elif; Aliyazıcıoğlu, Yüksel (Springer, 2023)Purpose Testicular toxicity is one of the most important side efects of cisplatin (CP) therapy. Alpha-pinene (AP) is a naturally occurring monoterpene with antioxidant character in plants. Here, we aimed to evaluate the ... -
Ameliorative effect of gallic acid on cisplatin-induced ovarian toxicity in rats
Ayazoğlu Demir, Elif; Menteşe, Ahmet; Livaoğlu, Ayten; Türkmen Alemdar, Nihal; Demir, Selim (Taylor & Francis Ltd., 2021)The aim of the present study was to evaluate the protective effect of gallic acid (GA) against cisplatin (CDDP)-induced ovarian toxicity, for the first time. The ovarian damage was generated with CDDP (5 mg/kg) intraperitoneally ... -
Evaluation of the therapeutic effects of arbutin on cisplatin-induced ovarian toxicity in rats through endoplasmic reticulum stress and Nrf2 pathway
Ayazoğlu Demir, Elif; Menteşe, Ahmet; Yılmaz, Zeynep Sağnak; Türkmen Alemdar, Nihal; Demir, Selim; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)Arbutin (ARB) is a glycosylated hydroquinone with potent antioxidant effects. Although cisplatin (CP) is widely used in chemotherapy, its toxicity in healthy tissues, including ovotoxicity, is an insurmountable problem. ... -
Gentisic acid ameliorates cisplatin-induced reprotoxicity through suppressing endoplasmic reticulum stress and upregulating Nrf2 pathway
Menteşe, Ahmet; Demir, Selim; Aydın Mungan, Sevdegül; Alemdar, Nihal Türkmen; Ayazoğlu Demir, Elif; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)Reproductive toxicity is a serious side effect of cisplatin (CP) chemotherapy. Gentisic acid (GTA) is a phenolic acid with strong antioxidant properties. Here, we aimed to determine therapeutic effect of GTA against ... -
p-Coumaric acid alleviates cisplatin-induced ovarian toxicity in rats
Ayazoğlu Demir, Elif; Menteşe, Ahmet; Küçük, Hatice; Türkmen Alemdar, Nihal; Demir, Selim (Wiley, 2021)Objective The therapeutic value of cisplatin (CDDP) as an anticancer drug is limited by its ovo-otoxicity. The effect of natural phenolic acids in the prevention of many diseases related to oxidative stress has been reported. ... -
Therapeutic effect of astaxanthin on 5-fluorouracil-induced ovarian damage in rats
Ayazoğlu Demir, Elif; Menteşe, Ahmet; Livaoğlu, Ayten; Alemdar, Nihal Türkmen; Demir, Selim; Aliyazıcıoğlu, Yüksel (Bilecik Şeyh Edebali Üniversitesi, 2024)Although astaxanthin (ASX) is one of the most studied antioxidant molecules, its curative effect against ovarian damage caused by 5-fluorouracil (5-FU) has not been demonstrated to date. It was therefore aimed to investigate ... -
Therapeutic effect of berberine against 5-fluorouracil induced ovarian toxicity in rats
Demir, Selim; Türkmen Alemdar, Nihal; Küçük, Hatice; Ayazoğlu Demir, Elif; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Taylor & Francis Ltd., 2024)Berberine (BER) is a naturally occurring alkaloid with a multitude of beneficial effects on human health. Although it is one of the most studied phytochemicals, its curative effect against ovarian damage caused by ...
