Yazar "Bayrak, Hacer" için listeleme
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Cyclization of some carbothioamide derivatives containing antipyrine and triazole moieties and investigation of their antimicrobial activities
Bayrak, Hacer; Demirbaş, Ahmet; Demirbas, Neslihan; Karaoğlu, Şengül Alpay (Elsevier, 2010)Acetohydrazide derivative containing both antipyrine and triazole nuclei (5) was obtained starting from ethyl hydrazinecarboxylate derivative (2) and 4-aminoantipyrine (1) by three steps. The treatment of compound 5 with ... -
Design and synthesis of new 1,2,4-triazole deriaties containing morpholine moiety as antimicrobial agents
Şahin, Deniz; Bayrak, Hacer; Demirbaş, Ahmet; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay (TÜBİTAK, 2012)2-Morpholine-4ylethyl-3H -1,2,4-triazole-3-ones (2a, 2b) were obtained from the condensation between the corresponding ethoxycarbonylhydrazones and 2-morpholinoethanamine. 2a was conerted to acetohydrazide (4) ia the ... -
Design and synthesis of some azole derivatives as potential antimicrobial agents
Şahin, Deniz; Bayrak, Hacer; Demirbaş, Ahmet; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay (Birkhauser Boston, 2012)Syntheses of 1,2,4-triazol-3-ones, 4a, 4b, and 5 were performed starting from ester ethoxycarbonylhyd-razones (1a, 1b) that were reported earlier. The treatment of triazole derivatives, 4a, 4b, and 5 with several sulfonyl ... -
Microwave assisted synthesis of some hybrid molecules derived from norfloxacin and investigation of their biological activities
Menteşe, Meltem Yolal; Bayrak, Hacer; Uygun, Yıldız; Mermer, Arif; Ülker, Serdar; Karaoğlu, Şengül Alpay; Demirbaş, Neslihan (Elsevier France-Editions Scientifiques Medicales Elsevier, 2013)Norfloxacin was converted to 7-(4-amino-2-fluorophenyl)piperazin derivative (2) via the formation of nitro compound. the synthesis of the norfloxacin derivatives containing 1,3-thiazole or 1,3-thiazolidin moiety was performed ... -
Microwave-assisted and conventional synthesis of novel antimicrobial 1,2,4-triazole derivatives containing nalidixic acid skeleton
Ceylan, Şule; Bayrak, Hacer; ÖZdemir, Serap Başoğlu; Uygun, Yıldız; Mermer, Arif; Demirbaş, Neslihan; Ülker, Serdar (Walter de Gruyter Gmbh, 2016)Carbothioamides 4a,b, obtained from nalidixic acid, were converted to the corresponding 1,3-thiazolidine derivatives 5a,b by cyclocondensation with 2-bromo-1-(4-chlorophenyl) ethanone. Treatment of 4a,b with base afforded ... -
Novel imidazo[2,1-b] [1,3,4]thiadiazole (ITD) hybrid compounds: Design, synthesis, efficient antibacterial activity and antioxidant effects
Taflan, Ebru; Bayrak, Hacer; Er, Mehtap; Karaoğlu, Şengül Alpay; Bozdeveci, Arif (Academic Press Inc Elsevier Science, 2019)In this study, novel imidazo[2,1-b] [1,3,4]thiadiazole (ITD) compounds were synthesized and their antimicrobial and antioxidant capacity was examined. the C-2 position of the ITD structure was fixed with the 3,4-hydroxybenzene ... -
Novel microwave assisted synthesis and antimicrobial activity of new quinolone-hybrids
Ceylan, Şule; Bayrak, Hacer; Özdemir, Serap Başoğlu; Uygun, Yıldız; Mermer, Arif; Demirbaş, Neslihan; Ülker, Serdar (Bentham Science Publ Ltd, 2016)Background: Carbo(thio)amid derivatives 4a, 4b were obtained starting from nalidixic acid in three steps. the acidic treatment of compound 4a generated the corresponding 1,3,4-oxadiazole (5), while the compound 4a gave ... -
Structure-based hybridization, microwave prompted synthesis and biological evaluation of novel 4-(2-fluoro-4-nitrophenyl)morpholine derivatives
Cebeci, Yıldız Uygun; Demirbaş, Neslihan; Özdemir, Serap Başoğlu; Bayrak, Hacer; Demirbaş, Ahmet; Aksakal, Fatma; Karaoğlu, Şengül Alpay (Bentham Science Publ Ltd, 2018)1,3,4-oxadiazole-2-thiole 6 was obtained from 4-(2-fluoro-4-nitrophenyl)morpholine (2) by the reduction of its nitro group and the sequential treatment of the resulting amine with ethyl bro-moacetate, hydrazine hydrate, ... -
Syntheses and biological activities of new hybrid molecules containing different heterocyclic moieties
Ceylan, Şule; Bektaş, Hakan; Bayrak, Hacer; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay; Ülker, Serdar (Wiley, 2013)4-Aryl-5-(pyridin-3-yl)-4H-1,2,4-triazole-3-(thi)oles 5-7, obtained starting from nicotinic acid hydrazide were converted to the corresponding Mannich bases 12-24 by the reaction with several heterocyclic amines in the ... -
Synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives
Bayrak, Hacer; Demirbaş, Ahmet; Bektaş, Hakan; Karaoğlu, Şengül Alpay; Demirbaş, Neslihan (TUBİTAK, 2010)The synthesis of ethyl [3-(cyanomethyl)-5-alkyl-4H-1,2,4-triazol-4-yl] carbamates (2a-d) was performed starting from ethyl 2-[ethoxy(4-(aryl)methylene] hydrazinecarboxylates (1a, 1b). The treatment of 2a with thiosemicarbazide ... -
Synthesis and antimicrobial activities of some new biheterocyclic compounds containing 1, 2, 4-triazol-3-one and 1, 3, 4-thiadiazole moieties
Bektaş, Hakan; Demirbaş, Ahmet; Demirbaş, Neslihan; Bayrak, Hacer; Karaoğlu, Şengül Alpay (TÜBİTAK, 2010)2-(4-Amino-3-(4-chlorophenyl)-5-oxo-4, 5-dihydro-1 H-1, 2, 4-triazol-1-yl)-N'-[(2, 6 dihalogenophenyl)-methylene]acetohydrazides (3a, b) was obtained via the formation of 2-(4-amino-3-(4-chlorophenyl)-5-oxo-4, 5-dihydro-1 ... -
Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds
Özdemir, Serap Başoğlu; Cebeci, Yıldız Uygun; Bayrak, Hacer; Mermer, Arif; Ceylan, Şule; Demirbaş, Ahmet; Karaoğlu, Şengül Alpay; Demirbaş, Neslihan (Walter de Gruyter Gmbh, 2017)The hydrazide 5, that was obtained from -1-(4-fluorophenyl) piperazine (1), was converted to the cor-responding carbothioamides 6a-c by the reaction with alkyl(aryl) isothiocyanates. the synthesis of conazole analogs 10a-f ... -
Synthesis of novel antipyrine derivatives possessing remarkable antimicrobial activities
Bayrak, Hacer; Cebeci, Yıldız Uygun; Karaoğlu, Şengül Alpay (Wiley-V C H Verlag Gmbh, 2019)In this study, new triazole, thiazole, oxazole and Mannich bases were synthesized starting from antipyrine. All the newly synthesized compounds were screened for their antimicrobial activities against some test microorganisms ... -
Synthesis of novel antipyrine-azole-S-alkyl derivatives antimicrobial activity, molecular docking, and computational studies
Cebeci, Yıldız Uygun; Bayrak, Hacer; Karaoğlu, Şengül Alpay; Fahim, Asmaa M. (Elsevier, 2022)In this investigation, we synthesized the newly antipyrine-azole-S-alkyl and their reduction derivatives that were screened for their antimicrobial activity and compared them with molecular docking and computational Studies. ... -
Synthesis of novel Azol-beta-lactam derivatives starting from phenyl piperazine and investigation of their antiurease activity and antioxidant capacity comparing with their molecular docking studies
Mermer, Arif; Bayrak, Hacer; Şirin, Yakup; Emirik, Mustafa; Demirbaş, Neslihan (Elsevier Science Bv, 2019)This study reports the synthesis, biological investigation and molecular docking of novel beta-lactam derivatives bearing 1,3,4-thiadiazole and 1,3,4-oxadiazole ring system. the synthesized compounds were evaluated for in ... -
Synthesis of some new 1,2,4-triazoles starting from isonicotinic acid hydrazide and evaluation of their antimicrobial activities
Bayrak, Hacer; Demirbağ, Ahmet; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay (Elsevier, 2009)5-Pyridin-4-yl-1,3,4-oxadiazole-2-thiol (2) was obtained from the reaction of isonicotinic acid hydrazide with carbon disulfide in basic media and converted into 4-amino-5-pyridin-4-yl-4H-1,2,4-triazole-3-thiol (5) by the ... -
Synthesis of some new 1,2,4-triazoles, their Mannich and Schiff bases and evaluation of their antimicrobial activities
Bayrak, Hacer; Demirbaş, Ahmet; Karaoğlu, Şengül Alpay; Demirbaş, Neslihan (Elsevier, 2009)4-Phenyl-5-pyridin-4-yl-4H-1,2,4-triazole-3-thiol (3) was obtained in basic media via the formation of 2-isonicotinoyl-N-phenylhydrazinecarbothioamide (2), and converted to some alkylated derivatives (4a,b) and Mannich ... -
Synthesis of some new hybride molecules containing several azole moieties and investigation of their biological activities
Ceylan, Şule; Bayrak, Hacer; Demirbaş, Ahmet; Ülker, Serdar; Alpay-Karaoğlu, Şengül; Demirbaş, Neslihan (Maik Nauka/Interperiodica/Springer, 2014)1,2,4-Triazole-3-one prepared from tryptamine was converted to the corresponding carbothioamides by several steps. Their treatment with ethyl bromoacetate or 4-chlorophenacyl bromide produced the corresponding 5-oxo-1,3- ... -
Synthesis, aggregation and spectroscopic studies of novel water soluble metal free, zinc, copper and magnesium phthalocyanines and investigation of their anti-bacterial properties
Bayrak, Rıza; Akçay, Hakkı Türker; Beriş, Fatih Şaban; Şahin, Ertan; Bayrak, Hacer; Demirbaş, Umit (Pergamon-Elsevier Science Ltd, 2014)In this study, novel phthalonitrile derivative (3) was synthesized by the reaction between 4-nitrophthalonitrile (2) and a triazole derivative (1) containing pyridine moiety. Crystal structure of compound (3) was characterized ...
