Yazar "Düzgün, Azer Özad" için listeleme
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Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing beta-lactamases in Pseudomonas aeruginosa in Turkey
Iraz, Meryem; Düzgün, Azer Özad; Çiçek, Ayşegül Çopur; Bonnin, Remy A.; Ceylan, Ayşenur; Saral, Ayşegül; Nordmann, Patrice; Sandalli, Cemal (Elsevier Science Inc, 2014)Pseudomonas aeruginosa isolates were collected form a Turkish hospital. Antimicrobial susceptibility was performed using the Vitek 2 Compact system, and 24 isolates were categorized as multidrug resistant (n = 18), ... -
Comparison of verona integron-borne metallo-beta-lactamase (VIM) variants reveals differences in stability and inhibition profiles
Makena, Anne; Düzgün, Azer Özad; Brem, Jurgen; McDonough, Michael A.; Rydzik, Anna M.; Abboud, Martine I.; Saral, Ayşegül; Çiçek, Ayşegül Çopur; Sandallı, Cemal; Schofield, Christopher J. (Amer Soc Microbiology, 2016)Metallo-beta-lactamases (MBLs) are of increasing clinical significance; the development of clinically useful MBL inhibitors is challenged by the rapid evolution of variant MBLs. the Verona integron-borne metallo-beta-lactamase ... -
Detection of class 1 integron in Acinetobacter baumannii isolates collected from nine hospitals in Turkey
Çiçek, Ayşegül Çopur; Düzgün, Azer Özad; Saral, Ayşegül; Kayman, Tuba; ÇIzmecI, Zeynep; Balci, Pervin Özlem; Dal, Tuba; Fırat, Mehmet; Tosun, İsmail; Altıntop, Yasemin Ay; Çalışkan, Ahmet; Yazıcı, Yelda; Sandallı, Cemal (Elsevier, 2013)Objective: To investigate the antibiotic resistance genes inserted into class 1 and class 2 integrons in Acinetobacter baumannii (A. baumannii) isolates obtained from nine different cities in Turkey. Methods: A collection ... -
Determination of a novel integron-located variant (bla(OXA-320)) of class D beta-lactamase in Proteus mirabilis
Çiçek, Ayşegül Çopur; Düzgün, Azer Özad; Saral, Ayşegül; Sandallı, Cemal (Wiley, 2014)Proteus mirabilis (P. mirabilis) is one of Gram-negative pathogens encountered in clinical specimens. A clinical isolate (TRP41) of P. mirabilis was isolated from a Turkish patient in Turkey. the isolate was identified ... -
Determination of antibiotic resistance genes and virulence factors in Escherichia coli isolated from Turkish patients with urinary tract infection
Düzgün, Azer Özad; Okumuş, Funda; Saral, Ayşegül; Çiçek, Ayşegül Çopur; Cinemre, Sedanur (Soc Brasileira Medicina Tropical, 2019)Introduction: Escherichia coli ranks among the most common sources of urinary tract infections (UTI). Methods: Between November 2015 and August 2016, 90 isolates of E coli were isolated from patients at Rize Education and ... -
Determination of the cytotoxicity and antibiofilm potential effect of equisetum arvense silver nanoparticles
Akar, Zeynep; Akay, Şeref; Ejder, Nebahat; Düzgün, Azer Özad (Springer, 2023)This study aimed to synthesize and characterize silver nanoparticles (AgNPs) by green synthesis from Equisetum arvense (Ea) extracts and to investigate their cytotoxicity, antibiofilm activity, and alpha-glucosidase enzyme ... -
Distribution of beta-lactamase genes among carbapenem-resistant klebsiella pneumoniae strains isolated from patients in Turkey
Iraz, Meryem; Düzgün, Azer Özad; Sandallı, Cemal; Doymaz, Mehmet Ziya; Akkoyunlu, Yasemin; Saral, Ayşegül; Peleg, Anton Y.; Özgümüş, Osman Birol; Beriş, Fatih Şaban; Karaoğlu, Hakan; Çiçek, Ayşegül Çopur (Korean Soc Laboratory Medicine, 2015)Background: the emergence of carbapenem-resistant Klebsiella pneumoniae poses a serious problem to antibiotic management. We investigated the beta-lactamases in a group of carbapenem-resistant K. pneumoniae clinical isolates ... -
Investigation of class 1 integrons with antibiotic resistance genes in multidrug-resistant acinetobacter baumannii strains and determination of plant extract effects on multidrug-resistant isolates
Saral, Ayşegül; Cinemre, Sedanur; Okumuş, Funda; Akar, Zeynep; Çiçek, Ayşegül Çopur; Düzgün, Azer Özad (Soc Stiinte Farmaceutice Romania, 2021)This study aimed to investigate the presence of resistance genes in multidrug-resistant A. baumannii isolates as well as to determine the antibacterial activity of selected plant extracts against isolates. 41 strains were ... -
Kinetic characterization of GES-22 beta-lactamase harboring the M169L clinical mutation
Saral, Ayşegül; Leonard, David A.; Düzgün, Azer Özad; Çiçek, Ayşegül Çopur; June, Cynthia M.; Sandallı, Cemal (Japan Antibiotics Research Assoc, 2016)The class A p-lactamase GES-22 has been identified in Acinetobacter baumannii isolates in Turkey, and subsequently shown to differ from GES-11 by a single substitution (M169L). Because M169 is part of the omega loop, a ... -
Klinik Pseudomonas aeruginosa izolatlarında β-laktamaz direnç genlerinin taranması ve yeni bir metallo-β-laktamazın (VIM-38) karakterizasyonu
Düzgün, Azer Özad (Recep Tayyip Erdoğan Üniversitesi / Fen Bilimleri Enstitüsü / Biyoloji Anabilim Dalı, 2015)Bu doktora tezinde, 104 P. aeruginosa suşu çalışılmıştır.Antibiyogram sonucuna göre izolatlardan 24 tanesinin çoklu ilaç-dirençli olduğu belirlendi. Tüm izolatlarda beta-laktam direnç genlerinin varlığı PZR yöntemiyle ... -
Nationwide study of Escherichia coli producing extended-spectrum beta-lactamases TEM, SHV and CTX-M in Turkey
Çiçek, Ayşegül Çopur; Saral, Ayşegül; Düzgün, Azer Özad; Yaşar, Ekrem; Çizmeci, Zeynep; Balcı, Pervin Özlem; Sarı, Fatma; Fırat, Mehmet; Altıntop, Yasemin Ay; Ak, Sibel; Çalışkan, Ahmet; Yıldız, Nazan; Sancaktar, Metin; Budak, Emine Esra; Ertürk, Ayşe; Özgüm, Osman Birol; Sandallı, Cemal (Nature Publishing Group, 2013)Four hundred and forty extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli isolates were collected from 10 different hospitals in Turkey between 2011 and 2012. Clinical specimens consisted of urine (80.45%), ... -
A Novel integron gene cassette harboring VIM-38 Metallo-beta-lactamase in a clinical pseudomonas aeruginosa isolate
Beriş, Fatih Şaban; Akyıldız, Esma; Düzgün, Azer Özad; Coşkun, Umut Safiye Say; Sandallı, Cemal; Çiçek, Ayşegül Çopur (Korean Soc Laboratory Medicine, 2016)Dear Editor, Multidrug resistance of Pseudomonas aeruginosa has been attributed to both intrinsic and acquired antibiotic-resistance mechanisms. Multidrug-resistant (MDR) P. aeruginosa isolates have become a serious ... -
OXA- and GES-type beta-lactamases predominate in extensively drug-resistant Acinetobacter baumannii isolates from a Turkish University Hospital
Çiçek, Ayşegül Çopur; Saral, Ayşegül; Iraz, Meryem; Ceylan, Ayşenur; Düzgün, Azer Özad; Peleg, Anton Y.; Sandallı, Cemal (Elsevier Sci Ltd, 2014)We determined the antibiotic susceptibility and genetic mechanisms of resistance in clinical strains of Acinetobacter baumannii from Istanbul, Turkey. A total of 101 clinical strains were collected between November 2011 ... -
Trabzon Fatih Devlet Hastanesinden İzole edilen klinik Acinetobacter baumannii ve Pseudomonas aeruginosa suşlarında antibiyotik direnç genlerinin araştırılması
Akyıldız, Esma; Saral, Ayşegül; Köse, Tuba; Beriş, Fatih Şaban; Düzgün, Azer Özad (Gümüşhane Üniversitesi, 2023)Bu çalışmanın amacı Acinetobacter baumannii ve Pseudomonas aeruginosa izolatlarının antibiyotik duyarlılık profilini araştırmak ve bu izolatlarda direnç genlerinin varlığını belirlemektir. Direnç genlerinin tespiti PCR ...
