Yazar "Demir, Selim" için listeleme
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Alleviating effect of alpha-pinene on testicular torsion and detorsion injury in rats
Demir, Selim; Kazaz, İlke Onur; Sağnak Yılmaz, Zeynep; Türkmen Alemdar, Nihal; Ayazoğlu Demir, Elif; Tepe, Recep Serhat; Menteşe, Ahmet (Galenos Yayınevi, 2023)Objective: It was aimed to evaluate whether alpha-pinene (AP) had a beneficial effect in the testicular ischemia/reperfusion injury (IRI) model for the first time. Materials and Methods: Testicular malondialdehyde, total ... -
Alpha-pinene neutralizes cisplatin-induced reproductive toxicity in male rats through activation of Nrf2 pathway
Demir, Selim; Menteşe, Ahmet; Türkmen Usta, Zeynep; Türkmen Alemdar, Nihal; Ayazoğlu Demir, Elif; Aliyazıcıoğlu, Yüksel (Springer, 2023)Purpose Testicular toxicity is one of the most important side efects of cisplatin (CP) therapy. Alpha-pinene (AP) is a naturally occurring monoterpene with antioxidant character in plants. Here, we aimed to evaluate the ... -
Ameliorative effect of gallic acid on cisplatin-induced ovarian toxicity in rats
Ayazoğlu Demir, Elif; Menteşe, Ahmet; Livaoğlu, Ayten; Türkmen Alemdar, Nihal; Demir, Selim (Taylor & Francis Ltd., 2021)The aim of the present study was to evaluate the protective effect of gallic acid (GA) against cisplatin (CDDP)-induced ovarian toxicity, for the first time. The ovarian damage was generated with CDDP (5 mg/kg) intraperitoneally ... -
The ameliorative effect of Primula vulgaris on cisplatin-induced nephrotoxicity in rats and quantification of its phenolic components using LC-ESI-MS/MS
Turan, İbrahim; Canbolat, Deniz; Demir, Selim; Kerimoğlu, Gökçen; Çolak, Fatih; Türkmen Alemdar, Nihal; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)Cisplatin (CDDP) is an important chemotherapeutic agent, accumulation of which in kidney tissue causes nephrotoxicity and renal failure. The aim of this study was to evaluate, for the first time in the literature, the ... -
Antioxidant, antigenotoxic, antimicrobial activities and phytochemical analysis of dianthus carmelitarum
Aliyazıcıoğlu, Rezzan; Demir, Selim; Badem, Merve; Şener, Sıla Özlem; Korkmaz, Nuriye; Demir, Elif Ayazoğlu; Özgen, Ufuk; Karaoğlu, Şengül Alpay; Aliyazıcıoğlu, Yüksel (2017)In this study, we investigated the phytochemical composition, antioxidant, antimicrobial, and antigenotoxic properties of the aqueous extract of Dianthus carmelitarum for the first time. The phenolic and volatile compounds, ... -
Arbutin abrogates testicular ischemia/reperfusion injury in rats through repression of inflammation and ER stress
Demir, Elif Ayazoğlu; Demir, Selim; Kazaz, İlke Onur; Küçük, Hatice; Alemdar, Nihal Türkmen; Büyük, Ali; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)The aim of this study was to investigate the effects of arbutin (ARB) administration on oxidative stress, inflammation, endoplasmic reticulum (ER) stress and apoptosis in an experimental testicular torsion/detorsion ... -
Autoantibodies against carbonic anhydrase I and II in patients with acute myeloid leukemia
Menteşe, Ahmet; Erkut, Nergiz; Demir, Selim; Yaman, Serap Özer; Sümer, Ayşegül; Doğramacı, Şeniz; Alver, Ahmet; Sönmez, Mehmet (2017)Amaç: Kanser, dünyadaki başlıca ölüm nedenlerinden birisi olup, küresel bir toplum sağlığı sorunudur. Organizmanın kendi antijenlerine karşı gelişen otoantikorlar pek çok kanser hastasının serumunda tespit edilmiştir. Son ... -
Carbonic anhydrase I and II autoantibodies in Behcet's disease
Mentese, Ahmet; Alver, Ahmet; Demir, Selim; Sümer, Ayşegül; Özer Yaman, Serap; Karkucak, Murat; Aydın Çapkın, Arzu; Us Altay, Diler; Turan, İbrahim (Publisaude-Edicoes Medicas Lda, 2017)Background: Behcet's disease ( BD) is a vasculitis, seen more frequently around the Mediterranean and the Far East, and evinces with oral and genital ulcerations, skin lesions and uveitis. Carbonic anhydrase ( CA) is a ... -
Carbonic anhydrase I-II autoantibodies and oxidative status in long-term follow-up of patients with Crimean-Congo haemorrhagic fever
Yılmaz, Hülya; Kostakoğlu, Uğur; Demir, Selim; Aksoy, Firdevs; Menteşe, Ahmet; Karahan, Süleyman Caner; Köksal, İftihar; Alver, Ahmet; Yılmaz, Gürdal (Taylor & Francis Ltd, 2018)Context: Crimean-Congo haemorrhagic fever (CCHF) is a life-threatening acute febrile haemorrhagic disease. Objective: This study was to measure levels of the oxidative stress biomarkers malondialdehyde (MDA), total oxidant ... -
Chlorogenic acid ameliorates torsion/detorsion-induced testicular injury via decreasing endoplasmic reticulum stress
Kazaz, İlke Onur; Demir, Selim; Kerimoğlu, Gökçen; Çolak, Fatih; Türkmen Alemdar, Nihal; Doğan, Sedanur Yılmaz; Bostan, Serdar; Menteşe, Ahmet (Elsevier, 2022)Backround Testicular torsion (TT) is an urological emergency situation especially in adolescents and young men. The main pathophysiology of testicular torsion/detorsion (T/D) is ischemia-reperfusion (I/R) injury. I/R ... -
Chlorogenic acid attenuates cisplatin-induced ovarian injury in rats
Demir, Elif Ayazoğlu; Menteşe, Ahmet; Livaoğlu, Ayten; Alemdar, Nihal Türkmen; Aliyazıcıoğlu, Yüksel; Demir, Selim (Taylor & Francis Ltd., 2023)The aim of this study was to determine the possible therapeutic effect of chlorogenic acid (CGA) on cisplatin (CDDP)-induced ovarian damage in rats. Rats were first exposed to CDDP (5 mg/kg) and then treated CGA (1.5 and ... -
Circulating parameters of oxidative stress and hypoxia in normal pregnancy and HELLP syndrome
Menteşe, Ahmet; Güven, Süleyman; Demir, Selim; Sümer, Ayşegül; Yaman, Serap Özer; Alver, Ahmet; Karahan, Süleyman Caner (Wroclaw Medical Univ, 2018)Background. the HELLP syndrome (Hemolysis, Elevated Liver enzymes and Low Platelets) is a complication of severe pre-eclampsia, a condition characterized by oxidative stress elevation caused by disequilibrium between lipid ... -
Detection of autoantibodies against carbonic anhydrase I and II in the plasma of patients with gastric cancer
Menteşe, Ahmet; Fidan, Evren; Alver, Ahmet; Demir, Selim; Yaman, Serap Özer; Sümer, Ayşegül; Fidan, Sami; Kavgacı, Halil; Turan, İbrahim (Termedia Publishing House Ltd, 2017)Cancer is the second leading cause of death and gastric cancer is the fourth most common cancer type worldwide. Investigation of autoantibodies in cancer patients has been a popular research area in recent years. the aim ... -
Diagnostic value of plasma pentraxin-3 in acute appendicitis
Aygün, Ali; Katipoğlu, Burak; Ïmamoğlu, Melih; Demir, Selim; Yadigaroğlu, Metin; Tatlı, Özgür; Yurtsever, Selim; Usta, Arif; Menteşe, Ahmet; Türkmen, Süha (Taylor and Francis Ltd, 2019)Purpose: To measure serum PTX3 levels in patients admitted with right lower quadrant pain to emergency department and to investigate whether this parameter will be helpful for the diagnosis of acute appendicitis. Materials ... -
Effect of chrysin on endoplasmic reticulum stress in a rat model of testicular torsion
Kazaz, İlke Onur; Demir, Selim; Kerimoğlu, Gökçen; Çolak, Fatih; Alemdar, Nihal Türkmen; Akman, Ahmet Uğur; Çeküç, Ozan Can; Menteşe, Ahmet (Taylor & Francis Ltd., 2021)Background The purpose of this study was to evaluate the possible therapeutic effect of chrysin (CHS) on testicular torsion/detorsion (T/D) injury in vivo through the mechanisms of oxidative stress and endoplasmic reticulum ... -
The effect of rosa pimpinellifolia extract on the proliferation of human tumor cells
Demir, Elif Ayazoğlu; Demir, Selim; Türkmen, Nihal; Turan, İbrahim (Kahramanmaras Sutcu Imam University, 2021)The aim of this study was to evaluate the antioxidant properties of R. pimpinellifolia and its cytotoxic effect against human colon (WiDr), liver (HepG2) and lung (A549) cancer cells compared with a normal fibroblast (BJ) ... -
Effects of homocysteine on adipocyte differentiation and CD36 gene expression in 3T3-L1 adipocytes
Menteşe, Ahmet; Alver, Ahmet; Sümer, Ayşegül; Demir, Selim (Springer, 2016)The aim of this study was to investigate the effects of homocysteine (Hcy), a risk factor for cardiovascular diseases, hypertension, stroke and obesity, on expression of CD36 that regulates uptake of oxidized low-density ... -
Ethyl pyruvate attenuates cisplatin-induced ovarian injury in rats via activating Nrf2 pathway
Demir, Selim; Menteşe, Ahmet; Küçük, Hatice; Yuluğ, Esin; Alemdar, Nihal Türkmen; Demir, Elif Ayazoğlu; Aliyazıcıoğlu, Yüksel (Taylor & Francis Ltd., 2023)Although cisplatin (CDDP) is an antineoplastic drug widely used for the treatment of various tumors, its toxicity on the reproductive system is a concern for patients. Ethyl pyruvate (EP) possesses potent antioxidant and ... -
Evaluation of the therapeutic effects of arbutin on cisplatin-induced ovarian toxicity in rats through endoplasmic reticulum stress and Nrf2 pathway
Ayazoğlu Demir, Elif; Menteşe, Ahmet; Yılmaz, Zeynep Sağnak; Türkmen Alemdar, Nihal; Demir, Selim; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)Arbutin (ARB) is a glycosylated hydroquinone with potent antioxidant effects. Although cisplatin (CP) is widely used in chemotherapy, its toxicity in healthy tissues, including ovotoxicity, is an insurmountable problem. ... -
Gallic acid attenuates torsion/detorsion-induced testicular injury in rats through suppressing of HMGB1/NF- κB axis and endoplasmic reticulum stress
Demir, Selim; Kazaz, İlke Onur; Kerimoğlu, Gökçen; Alemdar, Nihal Türkmen; Çolak, Fatih; Arıcı, Tuğba; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Elsevier, 2024)It was aimed to evaluate whether gallic acid (GA) have a beneficial effect in the testicular ischemia/reperfusion injury (IRI) model in rats for the first time. Testicular malondialdehyde, 8-hydroxy-2 '-deoxyguanosine, ...
