Yazar "Demirbaş, Ahmet" için listeleme
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Conventional and microwave irradiated synthesis, biological activity evaluation and molecular docking studies of highly substituted piperazine-azole hybrids
Mermer, Arif; Demirci, Serpil; Özdemir, Serap Başoğlu; Demirbaş, Ahmet; Ülker, Serdar; Ayaz, Faik Ahmet; Demirbaş, Neslihan (Elsevier Science Inc, 2017)Azole derivatives (3, 6) obtained starting from 1-(2-methoxyphenyl)piperazine were converted to the corresponding Mannich bases containing beta-lactame or flouroquinolone core via a one pot three component reaction. the ... -
Conventional and microwave-assisted total synthesis, antioxidant capacity, biological activity, and molecular docking studies of new hybrid compounds
Demirci, Serpil; Mermer, Arif; Ak, Gökhan; Aksakal, Fatma; Çolak, Nesrin; Demirbaş, Ahmet; Ayaz, Faik Ahmet; Demirbaş, Neslihan (Wiley, 2017)Thiomorpholine was converted to the corresponding 1,3,4-oxadiazole (4), arylidenehydrazide (5a-e), and 1,2,4-triazole (7a and, 7b) derivatives via the formation of hydrazide (3). Compounds 4 and 7 were next converted to ... -
Cyclization of some carbothioamide derivatives containing antipyrine and triazole moieties and investigation of their antimicrobial activities
Bayrak, Hacer; Demirbaş, Ahmet; Demirbas, Neslihan; Karaoğlu, Şengül Alpay (Elsevier, 2010)Acetohydrazide derivative containing both antipyrine and triazole nuclei (5) was obtained starting from ethyl hydrazinecarboxylate derivative (2) and 4-aminoantipyrine (1) by three steps. The treatment of compound 5 with ... -
Design and synthesis of new 1,2,4-triazole deriaties containing morpholine moiety as antimicrobial agents
Şahin, Deniz; Bayrak, Hacer; Demirbaş, Ahmet; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay (TÜBİTAK, 2012)2-Morpholine-4ylethyl-3H -1,2,4-triazole-3-ones (2a, 2b) were obtained from the condensation between the corresponding ethoxycarbonylhydrazones and 2-morpholinoethanamine. 2a was conerted to acetohydrazide (4) ia the ... -
Design and synthesis of some azole derivatives as potential antimicrobial agents
Şahin, Deniz; Bayrak, Hacer; Demirbaş, Ahmet; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay (Birkhauser Boston, 2012)Syntheses of 1,2,4-triazol-3-ones, 4a, 4b, and 5 were performed starting from ester ethoxycarbonylhyd-razones (1a, 1b) that were reported earlier. The treatment of triazole derivatives, 4a, 4b, and 5 with several sulfonyl ... -
Design, synthesis and biological activities of some 7-aminocephalosporanic acid derivatives
Başoğlu, Serap; Demirbaş, Ahmet; Ülker, Serdar; Alpay-Karaoğlu, Şengül; Demirbaş, Neslihan (Elsevier France-Editions Scientifiques Medicales Elsevier, 2013)The treatment of 7-ACA with 4-substituted benzensulfonyl chlorides afforded the compounds containing 4-nitro/aminophenyl sulfonylamino moiety in the cephalosporanic acid skeleton (2, 4). the synthesis of the cephalosporanic ... -
Microwave assisted synthesis and antimicrobial activity evaluation of new heterofunctionalized norfloxacine derivatives
Menteşe, Meltem; Demirci, Serpil; Özdemir, Serap B.; Demirbaş, Ahmet; Ülker, Serdar; Demirbaş, Neslihan (Bentham Science Publ Ltd, 2016)The synthesis of new hybrid compounds containing several heterocyclic groups namely norfloxacine, 1,2,4-triazole, 1,3,4-oxadiazole, piperazine, morpholine, thiomorpholine, 1,3,4-thiadiazole etc. was performed by conventional ... -
Piperazine-azole-fluoroquinolone hybrids: Conventional and microwave irradiated synthesis, biological activity screening and molecular docking studies
Mermer, Arif; Faiz, Özlem; Demirbaş, Ahmet; Demirbaş, Neslihan; Alagumuthu, Manikandan; Arumugam, Sivakumar (Academic Press Inc Elsevier Science, 2019)A series of new 1,2,4-triazole and 1,3,4-oxadiazole derivatives was obtained via several steps sequential reactions of phenyl piperazine. Then, these compounds were converted to the corresponding fluoroquinolone hybrids ... -
Preparation and antimicrobial activity evaluation of some quinoline derivatives containing an azole nucleus
Özyanık, Muhammet; Demirci, Serpil; Bektaş, Hakan; Demirbaş, Neslihan; Demirbaş, Ahmet; Karaoğlu, Şengül Alpay (2012)Quinoline-2-carbohydrazide (2) obtained from quinaldic acid (1) was converted to the corresponding carbothioamide 3 and carboxamide 6 by treatment with benzyliso(thio)cyanate. The basic treatment of 3 and 6 yielded the ... -
Reduction, Mannich reaction, and antimicrobial activity evaluation of some new 1,2,4-triazol-3-one derivatives
Fandaklı, Seda; Başoğlu, Serap; Bektaş, Hakan; Yolal, Meltem; Demirbaş, Ahmet; Karaoğlu, Şengül Alpay (TÜBİTAK, 2012)Ethyl[4-arylmethyleneamino-3-(4-metylphenyl)-5-oxo-4,5-dihydro-1H -1,2,4-triazole-1-yl]acetates (3a-e and 10a-d) were obtained starting from 4-amino-2,4-dihydro-3H -1,2,4-triazol-3-ones (1 and 9) in 2 steps. The treatment ... -
Structure-based hybridization, conventional and microwave irradiated synthesis, biological evaluation and molecular docking studies of new compounds derived from thiomorpholin
Demirci, Serpil; Aksakal, Fatma; Çolak, Nesrin; Ülker, Serdar; Demirbaş, Ahmet; Demirbaş, Neslihan (Bentham Science Publ Ltd, 2017)Background: the amine 2 obtained via two steps starting from thiomorpholine was converted into the corresponding 1,3-thiazole (4), arylmethileneamino (5a- d) and hydrazide (7) derivatives using conventional and also microwave ... -
Structure-based hybridization, microwave prompted synthesis and biological evaluation of novel 4-(2-fluoro-4-nitrophenyl)morpholine derivatives
Cebeci, Yıldız Uygun; Demirbaş, Neslihan; Özdemir, Serap Başoğlu; Bayrak, Hacer; Demirbaş, Ahmet; Aksakal, Fatma; Karaoğlu, Şengül Alpay (Bentham Science Publ Ltd, 2018)1,3,4-oxadiazole-2-thiole 6 was obtained from 4-(2-fluoro-4-nitrophenyl)morpholine (2) by the reduction of its nitro group and the sequential treatment of the resulting amine with ethyl bro-moacetate, hydrazine hydrate, ... -
Synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives
Bektaş, Hakan; Karaali, Nesrin; Şahin, Deniz; Demirbaş, Ahmet; Karaoğlu, Şengül Alpay; Demirbaş, Neslihan (MDPI, 2010)Some novel 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one (3, 6, 8, 9) derivatives and or 3-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3]benzoxazole (5) were synthesized from the reaction of various ester ethoxycarbo ... -
Synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives
Bayrak, Hacer; Demirbaş, Ahmet; Bektaş, Hakan; Karaoğlu, Şengül Alpay; Demirbaş, Neslihan (TUBİTAK, 2010)The synthesis of ethyl [3-(cyanomethyl)-5-alkyl-4H-1,2,4-triazol-4-yl] carbamates (2a-d) was performed starting from ethyl 2-[ethoxy(4-(aryl)methylene] hydrazinecarboxylates (1a, 1b). The treatment of 2a with thiosemicarbazide ... -
Synthesis and antimicrobial activities of some new biheterocyclic compounds containing 1, 2, 4-triazol-3-one and 1, 3, 4-thiadiazole moieties
Bektaş, Hakan; Demirbaş, Ahmet; Demirbaş, Neslihan; Bayrak, Hacer; Karaoğlu, Şengül Alpay (TÜBİTAK, 2010)2-(4-Amino-3-(4-chlorophenyl)-5-oxo-4, 5-dihydro-1 H-1, 2, 4-triazol-1-yl)-N'-[(2, 6 dihalogenophenyl)-methylene]acetohydrazides (3a, b) was obtained via the formation of 2-(4-amino-3-(4-chlorophenyl)-5-oxo-4, 5-dihydro-1 ... -
Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds
Özdemir, Serap Başoğlu; Cebeci, Yıldız Uygun; Bayrak, Hacer; Mermer, Arif; Ceylan, Şule; Demirbaş, Ahmet; Karaoğlu, Şengül Alpay; Demirbaş, Neslihan (Walter de Gruyter Gmbh, 2017)The hydrazide 5, that was obtained from -1-(4-fluorophenyl) piperazine (1), was converted to the cor-responding carbothioamides 6a-c by the reaction with alkyl(aryl) isothiocyanates. the synthesis of conazole analogs 10a-f ... -
Synthesis and biological activity studies of new hybrid molecules containing tryptamine moiety
Bektaş, Hakan; Demirbaş, Ahmet; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay (Springer, 2012)The synthesis of N?-(4-substitutedphenylsulfonyl)-2-{4-[2-(1H-indol- yl)ethyl]-3-(4-chlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl} acetohydrazides (3a-c), 2-{4-[2-(1H-indol-3-yl)ethyl]-3-(4-chlorobenzyl)-5-oxo- ... -
Synthesis of eperezolid-like molecules and evaluation of their antimicrobial activities
Yolal, Meltem; Başoğlu, Serap; Bektaş, Hakan; Demirci, Serpil; Karaoğlu, Şengül Alpay; Demirbaş, Ahmet (Springer Link, 2012)3-Fluoro-4-(4-phenylpiperazin-l-yl)aniline (II) prepared from 3,4-difluoro nitrobenzene was converted to the corresponding Schiff bases (III) and (IV) by treatment with 4-methoxybenzaldehyde and indol-3-carbaldehyde, ... -
Synthesis of some heterofunctionalized penicillanic acid derivatives and investigation of their biological activities
Demirci, Serpil; Demirbaş, Ahmet; Ülker, Serdar; Alpay-Karaoğlu, Şengül; Demirbaş, Neslihan (Wiley-V C H Verlag Gmbh, 2014)6-Substituted amino-penicillanic acid esters were synthesized starting with 6-apa. the compounds containing a 1,3-thiazole- or 1,3-thiazolidinone nucleus linked to the penicillanic acid skeleton via a hydrazino linkage ... -
Synthesis of some new 1,2,4-triazoles, their Mannich and Schiff bases and evaluation of their antimicrobial activities
Bayrak, Hacer; Demirbaş, Ahmet; Karaoğlu, Şengül Alpay; Demirbaş, Neslihan (Elsevier, 2009)4-Phenyl-5-pyridin-4-yl-4H-1,2,4-triazole-3-thiol (3) was obtained in basic media via the formation of 2-isonicotinoyl-N-phenylhydrazinecarbothioamide (2), and converted to some alkylated derivatives (4a,b) and Mannich ...
