Yazar "Demirci, Serpil" için listeleme
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Conventional and microwave irradiated synthesis, biological activity evaluation and molecular docking studies of highly substituted piperazine-azole hybrids
Mermer, Arif; Demirci, Serpil; Özdemir, Serap Başoğlu; Demirbaş, Ahmet; Ülker, Serdar; Ayaz, Faik Ahmet; Demirbaş, Neslihan (Elsevier Science Inc, 2017)Azole derivatives (3, 6) obtained starting from 1-(2-methoxyphenyl)piperazine were converted to the corresponding Mannich bases containing beta-lactame or flouroquinolone core via a one pot three component reaction. the ... -
Conventional and microwave-assisted total synthesis, antioxidant capacity, biological activity, and molecular docking studies of new hybrid compounds
Demirci, Serpil; Mermer, Arif; Ak, Gökhan; Aksakal, Fatma; Çolak, Nesrin; Demirbaş, Ahmet; Ayaz, Faik Ahmet; Demirbaş, Neslihan (Wiley, 2017)Thiomorpholine was converted to the corresponding 1,3,4-oxadiazole (4), arylidenehydrazide (5a-e), and 1,2,4-triazole (7a and, 7b) derivatives via the formation of hydrazide (3). Compounds 4 and 7 were next converted to ... -
Design, synthesis and antimicrobial activities of some azole derivatives
Başoğlu, Serap; Yolal, Meltem; Demirci, Serpil; Demirbaş, Neslihan; Bektaş, Hakan; Karaoğlu, Şengül Alpay (2013)Three new 1,3,4-oxadiazole, 1,3-thiazolidine and 1,2,4-triazole derivatives were obtained starting from furan-2-carbohydrazide. Then, 1,2,4-triazole compound was converted to the corresponding Mannich bases using several ... -
Microwave assisted synthesis and antimicrobial activity evaluation of new heterofunctionalized norfloxacine derivatives
Menteşe, Meltem; Demirci, Serpil; Özdemir, Serap B.; Demirbaş, Ahmet; Ülker, Serdar; Demirbaş, Neslihan (Bentham Science Publ Ltd, 2016)The synthesis of new hybrid compounds containing several heterocyclic groups namely norfloxacine, 1,2,4-triazole, 1,3,4-oxadiazole, piperazine, morpholine, thiomorpholine, 1,3,4-thiadiazole etc. was performed by conventional ... -
Preparation and antimicrobial activity evaluation of some new bi- and triheterocyclic azoles
Demirci, Serpil; Başoğlu, Serap; Bozdeveci, Arif; Demirbaş, Neslihan (Springer Birkhauser, 2013)Synthesis of the carbothioamides (5, 13, 22) was performed starting from 3H-1,2,4-triazol-3-ones (2, 17) by several steps, and then, these carbothioamides was converted to triheterocyclic compounds incorporating 1,2,4-triazole, ... -
Preparation and antimicrobial activity evaluation of some quinoline derivatives containing an azole nucleus
Özyanık, Muhammet; Demirci, Serpil; Bektaş, Hakan; Demirbaş, Neslihan; Demirbaş, Ahmet; Karaoğlu, Şengül Alpay (2012)Quinoline-2-carbohydrazide (2) obtained from quinaldic acid (1) was converted to the corresponding carbothioamide 3 and carboxamide 6 by treatment with benzyliso(thio)cyanate. The basic treatment of 3 and 6 yielded the ... -
Structure-based hybridization, conventional and microwave irradiated synthesis, biological evaluation and molecular docking studies of new compounds derived from thiomorpholin
Demirci, Serpil; Aksakal, Fatma; Çolak, Nesrin; Ülker, Serdar; Demirbaş, Ahmet; Demirbaş, Neslihan (Bentham Science Publ Ltd, 2017)Background: the amine 2 obtained via two steps starting from thiomorpholine was converted into the corresponding 1,3-thiazole (4), arylmethileneamino (5a- d) and hydrazide (7) derivatives using conventional and also microwave ... -
Synthesis and antimicrobial activity evaluation of new norfloxacine-azole hybrids
Demirci, Serpil; Demirbaş, Neslihan; Menteşe, Meltem; Özdemir, Serap Başoğlu; Karaoğlu, Şengül Alpay (Walter de Gruyter Gmbh, 2018)Norfloxacin-azole hybrids 3 and 6a,b were synthesized starting from norfloxacin. the treatment of these compounds with amines as a one-pot three-component reaction produced the corresponding amino derivatives 4a,b, 7a-g ... -
Synthesis of eperezolid-like molecules and evaluation of their antimicrobial activities
Yolal, Meltem; Başoğlu, Serap; Bektaş, Hakan; Demirci, Serpil; Karaoğlu, Şengül Alpay; Demirbaş, Ahmet (Springer Link, 2012)3-Fluoro-4-(4-phenylpiperazin-l-yl)aniline (II) prepared from 3,4-difluoro nitrobenzene was converted to the corresponding Schiff bases (III) and (IV) by treatment with 4-methoxybenzaldehyde and indol-3-carbaldehyde, ... -
Synthesis of some heterofunctionalized penicillanic acid derivatives and investigation of their biological activities
Demirci, Serpil; Demirbaş, Ahmet; Ülker, Serdar; Alpay-Karaoğlu, Şengül; Demirbaş, Neslihan (Wiley-V C H Verlag Gmbh, 2014)6-Substituted amino-penicillanic acid esters were synthesized starting with 6-apa. the compounds containing a 1,3-thiazole- or 1,3-thiazolidinone nucleus linked to the penicillanic acid skeleton via a hydrazino linkage ...
