Yazar "Küçük, Hatice" için listeleme
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Arbutin abrogates testicular ischemia/reperfusion injury in rats through repression of inflammation and ER stress
Demir, Elif Ayazoğlu; Demir, Selim; Kazaz, İlke Onur; Küçük, Hatice; Alemdar, Nihal Türkmen; Büyük, Ali; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)The aim of this study was to investigate the effects of arbutin (ARB) administration on oxidative stress, inflammation, endoplasmic reticulum (ER) stress and apoptosis in an experimental testicular torsion/detorsion ... -
Ethyl pyruvate attenuates cisplatin-induced ovarian injury in rats via activating Nrf2 pathway
Demir, Selim; Menteşe, Ahmet; Küçük, Hatice; Yuluğ, Esin; Alemdar, Nihal Türkmen; Demir, Elif Ayazoğlu; Aliyazıcıoğlu, Yüksel (Taylor & Francis Ltd., 2023)Although cisplatin (CDDP) is an antineoplastic drug widely used for the treatment of various tumors, its toxicity on the reproductive system is a concern for patients. Ethyl pyruvate (EP) possesses potent antioxidant and ... -
Gentisic acid attenuates 5-fluorouracil-induced ovotoxicity in rats via modulating Nrf2 signalling: An experimental approach
Menteşe, Ahmet; Demir, Selim; Yuluğ, Esin; Küçük, Hatice; Alemdar, Nihal Türkmen; Demir, Elif Ayazoğlu; Aliyazıcıoğlu, Yüksel (Elsevier, 2024)5-Fluorouracil (5-FU) is the third most used chemotherapeutic in the world with its anticancer effect resulting from its potential to block DNA replication. Like other cytotoxic agents, 5-FU has side effects on healthy ... -
N-acetylcysteine ameliorates 5-fluorouracil-induced ovarian injury in rats
Demir, Elif Ayazoğlu; Menteşe, Ahmet; Küçük, Hatice; Alemdar, Nihal Türkmen; Demir, Selim; Aliyazıcıoğlu, Yüksel (Marmara Üniversitesi, 2023)Objective: Although 5-fluorouracil (5-FU) is one of the most commonly used chemotherapeutics worldwide, it has been shown that 5-FU administration can cause reproductive toxicity in recent years. N-acetylcysteine (NAC) is ... -
p-Coumaric acid alleviates cisplatin-induced ovarian toxicity in rats
Ayazoğlu Demir, Elif; Menteşe, Ahmet; Küçük, Hatice; Türkmen Alemdar, Nihal; Demir, Selim (Wiley, 2021)Objective The therapeutic value of cisplatin (CDDP) as an anticancer drug is limited by its ovo-otoxicity. The effect of natural phenolic acids in the prevention of many diseases related to oxidative stress has been reported. ... -
Syringic acid ameliorates ischemia/reperfusion-induced testicular injury in rats via suppressing of HMGB1/NF-kappa B axis and endoplasmic reticulum stress
Demir, Elif Ayazoğlu; Demir, Selim; Kazaz, İlke Onur; Küçük, Hatice; Alemdar, Nihal Türkmen; Geçici, Ömer Faruk; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Springer, 2023)PurposeTo investigate the possible protective role of syringic acid on torsion/detorsion-induced testicular injury using biochemical and histopathological approaches for the first time.MethodsA total of 24 rats were divided ... -
Therapeutic effect of berberine against 5-fluorouracil induced ovarian toxicity in rats
Demir, Selim; Türkmen Alemdar, Nihal; Küçük, Hatice; Ayazoğlu Demir, Elif; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Taylor & Francis Ltd., 2024)Berberine (BER) is a naturally occurring alkaloid with a multitude of beneficial effects on human health. Although it is one of the most studied phytochemicals, its curative effect against ovarian damage caused by ... -
The therapeutic effect of silibinin against 5-fluorouracil-induced ovarian toxicity in rats
Demir, Elif Ayazoğlu; Menteşe, Ahmet; Küçük, Hatice; Alemdar, Nihal Türkmen; Demir, Selim (Wiley, 2023)5-Fluorouracil (5-FU) is a fluoropyrimidine group antineoplastic drug with antimetabolite properties and ovotoxicity is one of the most important side effects. Silibinin (SLB) is a natural compound that is used worldwide ... -
Vanillic acid abrogates cisplatin-induced ovotoxicity through activating Nrf2 pathway
Menteşe, Ahmet; Demir, Selim; Küçük, Hatice; Yuluğ, Esin; Alemdar, Nihal Türkmen; Demir, Elif Ayazoğlu; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)Although cisplatin (CDDP) is an effective anticancer agent, the ovotoxicity that can occur in female patients limits its use. Oxidative stress (OS) and inflammation are known to contribute to CDDP-induced ovotoxicity. ...
