Yazar "Nalkıran, Hatice Sevim" için listeleme
-
Anticancer effects of a novel herbal combination as a potential therapeutic candidate against lung cancer
Saydam, Faruk; Nalkıran, Hatice Sevim (Elsevier Science, 2021)Introduction: Cancer continues to be a prevalent health problem with increasing mortality rates. The interest in complementary medicine for cancer treatment has increased in recent years. In this study, we aimed to investigate ... -
Association of paraoxonase-1 L55M and Q192R polymorphisms with PCOS risk and potential risk factors for atherosclerosis
Nalkıran, Hatice Sevim; Şahin, Serap Baydur; Ayaz, Teslime; Nalkıran, İhsan; Güzel, Ali İrfan; Eldeş, Tuğba; Yıldız, Yasin (Future Medicine Ltd, 2019)Aim: To examine the PON1-L55M and-Q192R polymorphisms for polycystic ovary syndrome (PCOS) risk in relation with atherosclerosis risk markers. Methods: Blood samples were collected from 203 women (PCOS [n = 151], control ... -
The association of Sort1 expression with LDL subfraction and inflammation in patients with coronary artery disease
Atak, Mehtap; Sevim Nalkıran, Hatice; Bostan, Mehmet; Uydu, Huseyin Avni (Taylor & Francis Ltd., 2023)Background: Controversial effect of sortilin on lipoprotein metabolism in the development of atherosclerosis reveals the need for more extensive research Objectives: The aim of this study was to investigate the association ... -
Comparison of DNA isolation methods from mammalian sperm cells and development of a new protocol
Nalkıran, Hatice Sevim; Nalkıran, İhsan; Rakıcı, Sema Yılmaz; Tümkaya, Levent; Güzel, Ali İrfan (Effect Publishing Agency ( EPA ), 2021)Sperm DNA tightly packed with protamines makes the DNA isolation procedure from sperm cells long and laborious. Cell lysis is also a challenging step because of the disulfide bonds-rich membranes of the sperm cells. In ... -
Development of MoS2 and Au nanoparticle including disposable CEA-based immuno-cytosensor platforms
Altuntaş, Derya Bal; Nalkıran, Hatice Sevim; Aslan, Sema; Yolcu, Zuhal (Springer, 2022)In this study, an electrochemical biosensor for determination of Carcinoembryonic antigen (CEA) biomarker using human breast ductal adenocarcinoma (MCF-7) and human ovarian adenocarcinoma (SK-OV-3) cancer cells was presented. ... -
Effects of hippophae rhamnoides extract on oxidative mucosal injury induced by cisplatin in rat jejunum
Arslan, Aynur; Özçiçek, Fatih; Çimen, Ferda Keskin; Nalkıran, Hatice Sevim; Gülaboğlu, Mine; Çetin, Nihal; Çoban, Taha Abdulkadir; Kuzucu, Mehmet (Scientific Publishers of India, 2018)Objectives: We aimed to assess the effect of Hippophae rhamnoides extract (HR) on oxidative stress induced by cisplatin (Cis) in rat small intestine tissue by evaluating the biochemical and gene expression levels and ... -
Effects of nimesulide on oxidative mucosal injury induced by cisplatin in rat duodenum and jejunum
Özçiçek, Fatih; Çankaya, Murat; Çimen, Ferda K.; Kafa, Ayşe H. T.; Nalkıran, Hatice Sevim; Süleyman, Bahadır; Altuner, Durdu; Çetin, Nihal (Colegio Farmaceuticos Provincia de Buenos Aires, 2016)In this study, the impact of nimesulide on oxidative stress induced by cisplatin in rat duodenum and jejunum tissue was assessed by evaluating the biochemical and histopathological changes. the rats in the study were ... -
Effects of nimesulide on the small intestine mucositis induced by methotrexate in rats
Arslan, Aynur; Özçiçek, Adalet; Süleyman, Bahadır; Çoban, Taha Abdulkadir; Çimen, Ferda Keskin; Nalkıran, Hatice Sevim; Kuzucu, Mehmet; Altuner, Durdu; Çetin, Nihal; Süleyman, Halis (Int Press Editing Centre Inc, 2016)Intestinal mucositis is one of the major problems in the patients receiving cancer treatment. Nimesulide is a drug with antioxidant, antiinflammatory and antiulcer features. We aimed to investigate the effect of nimesulide ... -
An electrochemical immuno-cytosensor modified with nanofibers for the determination of a carcinoembryonic antigen
Yıldızbakan, Zehra; Altuntaş, Derya Bal; Nalkıran, Hatice Sevim; Aslan, Sema; Mamuk, Atilla Eren; Koçak, Çağdaş; Kurt, Şeymanur; Nalkıran, İhsan; Yener, Çiğdem; Ünlü, C. Gökhan (Springer, 2024)In this study, La0.25Fe0.75FeO3 (PNp)perovskite nanoparticle was synthesized using the sol–gel method. PNp-coated polyacrylonitrile (PAN) nanofibers were prepared by electrospinning on the pencil graphite electrode (PGE) ... -
Genetic variations in OLR1 gene associated with PCOS and atherosclerotic risk factors
Şahin, Serap Baydur; Nalkıran, İhsan; Ayaz, Teslime; Güzel, Ali İrfan; Eldeş, Tuğba; Calapoğlu, Tuğba; Nalkıran, Hatice Sevim (Sage Publications, 2023)Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age. The aim of this study was to investigate the association of oxidized low-density lipoprotein receptor 1 (OLR1) gene variations ... -
Inhibition of O6-methylguanine-DNA-methyltransferase (MGMT) by lomeguatrib reduces multiple myeloma cell viability and impairs DNA repair in MGMT-proficient cells
Akçora Yıldız, Dilara; Özkan, Tülin; Çetintav, Bekir; Yükselten, Yunus; Çalış, Şeyma; Nalkıran, Hatice Sevim; Türkel, Nezaket; Gündüz, Mehmet; Özen, Mehmet; Beksaç, Meral; Sunguroğlu, Asuman (Wiley, 2024)The function of direct DNA damage repair protein, namely MGMT in MM, and the impact of MGMT on melphalan treatment remains unclear. We showed a significantly higher MGMT mRNA expression in CD138+ myeloma cells than in ... -
Investigation of a glioblastoma risk-associated SNP of the PTPRB Gene in familial glioblastoma
Sevim Nalkıran, Hatice; Rakıcı, Sema Yılmaz; Nalkıran, İhsan (Turkiye Klinikleri, 2023)Objective: To investigate the association of the single nucleotide polymorphism (SNP) rs2252784 in the protein tyrosine phos-phatase receptor type B (PTPRB) gene with familial glioblastoma multiforme (GBM). Material and ... -
Investigation of mucus obtained from different fish species on the acute pain induced with scalpel incision in paw of rats
Çetin, Nihal; Süleyman, Bahtiyar; Kuyrukluyıldız, Ufuk; Nalkıran, Hatice Sevim; Kıran, Altan; Gençoğlu, Songül; Düzgün, Ahmet; Kurtoğlu, İlker Zeki; Yaralı, Oğuzhan; Gül, Mehmet Ali; Süleyman, Halis (Int Press Editing Centre Inc, 2016)No comparative study could be found for the analgesic activity of mucuses from the Oncorhynchus mykiss (OM), Salvelinus fontinalis (SF), Salmo coruhensis (SC), Acipenser gueldenstaedtii (AG), and Acipenserbaerii (AB) fish ... -
Is neuroglial antigen 2 a potential contributor to cilengitide response in glioblastoma?
Nalkıran, Hatice Sevim; McDonald, Kerrie Leanne (Medknow Publications & Media Pvt Ltd, 2017)Background: Determining the expression levels of neuroglial antigen 2 (NG2) in glioma cell lines and to evaluate the potential contribution of NG2 to cilengitide response were aimed. Materials and Methods: Endogenous ... -
Pelvic radiation-induced testicular damage: an experimental study at 1 gray
Rakıcı, Sema Yılmaz; Güzel, Ali İrfan; Tümkaya, Levent; Nalkıran, Hatice Sevim; Mercantepe, Tolga (Taylor & Francis Inc, 2020)Therapeutic radiation of the pelvic region has been shown to cause damage to testicular germ cells. in this study we aimed to evaluate the effects of a low therapeutic dose of 1 Gy on the induction of cellular and histological ... -
Prognostic importance of PD-L1 expression in bladder cancer patients
Durur, Sümeyye; Uzun, Hakkı; Bedir, Recep; Nalkıran, İhsan; Nalkıran, Hatice Sevim (Wolters Kluwer Medknow Publications, 2023)Background: PD-L1/PD-1 molecules are known as important mediators in immune-escape mechanisms of tumors. PD-L1 is highly expressed in various malignancies, including bladder cancer. However, the prognostic value of PD-L1 ... -
Repurposing ibudilast in combination with temozolomide for glıoblastoma
McDonald, Kerrie; Ha, Wendy; Nalkıran, Hatice Sevim; Khasraw, Mustafa (Oxford Univ Press Inc, 2016)Aims: Recurrence in patients with Glioblastoma (GBM) is inevitable, even in patients with O-6-Methylguanine-DNA Methyl Transferase (MGMT) methylation. -
Targeting the anaphase-promoting complex/cyclosome (APC/C) enhanced antiproliferative and apoptotic response in bladder cancer
Nalkıran, Hatice Sevim; Yıldız, Dilara Akcora; Saydam, Faruk; Güzel, Ali İrfan; Nalkıran, İhsan (Elsevier, 2023)Improving the chemotherapy sensitivity of bladder cancer is a current clinical challenge. It is critical to seek out effective combination therapies that include low doses of cisplatin due to its dose-limiting toxicity. ... -
To determine LDL phenotypes using lipids, lipoproteins, apoproteins, and sdLDL through association rule mining
Atak, Mehtap; Kıvrak, Mehmet; Nalkıran, Hatice Sevim; Uydu, Hüseyin Avni; Şatıroğlu, Ömer (Erciyes University Faculty of Medicine, 2023)Objective: The atherogenic lipoprotein phenotype is closely associated with the risk assessment of Coronary Artery Disease (CAD) and the monitoring of treatment processes. Particularly, high levels of small dense low-density ...
