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Arbutin abrogates cisplatin-induced hepatotoxicity via upregulating Nrf2/HO-1 and suppressing genotoxicity, NF-κB/iNOS/TNF-α and caspase-3/Bax/Bcl2 signaling pathways in rats
Okkay, Irmak Ferah; Famurewa, Ademola; Bayram, Cemil; Okkay, Ufuk; Mendil, Ali Sefa; Sezen, Selma; Ayaz, Teslime; Gecili, Ibrahim; Özkaraca, Mustafa; Şenyayla, Selçuk; Hacımüftüoğlu, Ahmet (Oxford University Press, 2024)Background: Cisplatin is a potent anticancer agent widely employed in chemotherapy. However, cisplatin leads to toxicity on non-targeted healthy organs, including the liver. We investigated the hepatoprotective mechanism ... -
Syringic acid protects against thioacetamide-induced hepatic encephalopathy: Behavioral, biochemical, and molecular evidence
Okkay, Irmak Ferah; Okkay, Ufuk; Gündoğdu, Ömer Lütfi; Bayram, Cemil; Mendil, Ali Sefa; Ertuğrul, Muhammed Sait; Hacımüftüoğlu, Ahmet (Elsevier, 2021)The objective of this study was to elucidate the effects of syringic acid on thioacetamide-induced hepatic encephalopathy which is a complex serious syndrome with neuropsychiatric abnormalities related to acute liver ...
