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Antimicrobial and antiurease activities of newly synthesized morpholine derivatives containing an azole nucleus
Bektaş, Hakan; Ceylan, Şule; Demirbaş, Neslihan; Alpay-Karaoğlu, Şengül; Sökmen, Bahar Bilgin (Birkhauser Boston, 2013)2-[6-(Morpholin-4-yl)pyridin-3-ylamino]acetohydrazide (4) was obtained starting from 6-morpholin-4-ylpyridin-3-amine (2) via the formation of ester (3) and then converted to the corresponding Schiff bases (5, 6) with the ... -
Benzimidazolone-piperazine/triazole/thiadiazole/furan/thiophene conjugates: Synthesis, in vitro urease inhibition, and in silico molecular docking studies
Güven, Okan; Menteşe, Emre; Emirik, Mustafa; Sökmen, Bahar Bilgin; Akyüz, Gülay (Wiley, 2023)This study describes the synthesis, in vitro urease inhibition, and molecular docking studies of benzimidazolone derivatives incorporating the piperazine, triazole, thiadiazole, furan, thiophene, and thiosemicarbazide ... -
Design, molecular docking and synthesis of novel 5,6-dichloro-2-methyl-1H-benzimidazole derivatives as potential urease enzyme inhibitors
Menteşe, Emre; Emirik, Mustafa; Sökmen, Bahar Bilgin (Academic Press Inc Elsevier Science, 2019)A novel series of 5,6-dichloro-2-methyl-1H-benzimidazole derivatives was synthesized and then screened for their urease inhibitory activity. All compounds showed more potent inhibitory activity in the range of IC50= 0.0294 ... -
Synthesis and biological evaluation of coumarin-amino acid-benzotriazole conjugates
Menteşe, Emre; Çalışkan, Nedime; Sökmen, Bahar Bilgin; Akyüz, Gülay (Springer, 2024)Objective: It is aimed to synthesize new amino acid-conjugated coumarin-benzotriazole molecules and to investigate their acetylcholinesterase, urease, and lipase inhibition properties. Methods: Urease inhibitory activities ... -
Synthesis and biological evaluation of some 1,3-benzoxazol-2(3H)-one hybrid molecules as potential antioxidant and urease inhibitors
Yılmaz, Fatih; Menteşe, Emre; Sökmen, Bahar Bilgin (Wiley, 2020)A new series of 1,3-benzoxazol-2(3H)-one hybrid compounds, including coumarin, isatin 1,3,4-triazole and 1,3,4-thiadiazole moieties, were synthesized and biologically evaluated for their antioxidant capacities and anti-urease ... -
Synthesis and in vitro urease inhibition of some novel benzimidazole-based hydrazones
Menteşe, Emre; Sökmen, Bahar Bilgin (Wiley, 2019)A novel series of N '-(substituted benzylidene)-2-(5,6-dichloro-2-methyl-1H-benzimidazol-1-yl)acetohydrazides and N '-(1-(substituted phenyl)ethylidene)-2-(5,6-dichloro-2-methyl-1H-benzimidazol-1-yl)acetohydrazides were ... -
Synthesis and molecular docking study of some 5,6-dichloro-2cyclopropyl-1H-benzimidazole derivatives bearing triazole, oxadiazole, and imine functionalities as potent inhibitors of urease
Menteşe, Emre; Bektaş, Hakan; Sökmen, Bahar Bilgin; Emirik, Mustafa; Çakır, Demet; Kahveci, Bahittin (Pergamon-Elsevier Science Ltd, 2017)A new series of benzimidazole compounds including hydrazinecarbothioamide, 1,2,4-triazole, 1,3,4-oxadiazole and imine function were synthesized starting from 5,6-dichloro-2-cyclopropyl-1H-benzimidazole. All of the benzimidazole ... -
Synthesis and spectroscopic characterization of novel methoxy bridged benzimidazolyl-substituted phthalocyanines as potent inhibitors of urease
Akçay, Hakkı Türker; Menteşe, Emre; Sökmen, Bahar Bilgin (Pergamon-Elsevier Science Ltd, 2020)In this study, novel peripherally 4-[(1H-benzimidazol-1-yl)methoxy] substituted Zn(II) (3) Cu(II) (4) and Co(II) (5) phthalocyanines were prepared and their structures were characterized spectroscopically. the light ... -
Synthesis of some benzimidazole-thiophene hybrids as potential urease and lipase inhibitors
Yılmaz, Fatih; Menteşe, Emre; Sökmen, Bahar Bilgin (Springer Link, 2023)In this study, some benzimidazole-thiophene hybrid compounds containing isatin and salicyl moieties were synthesized and investigated for their urease and lipase inhibition properties. Most of the synthesized compounds ... -
Synthesis of some new Methoxy Bridged Benzimidazolyl-Substituted phthalocyanines as potent inhibitors of urease
Demirbaş, Ümit; Menteşe, Emre; Sökmen, Bahar Bilgin; Bayrak, Rıza; Akçay, Hakkı Türker (Elsevier Science Sa, 2018)In this study, the novel peripherally 4-[(2-methyl-1H-benzimidazol-1-yl)methoxy] substituted Zn(II) (3) Cu(II) (4), Co(II) (5) phthalocyanines were prepared and their structures were characterized spectro-scopically. the ... -
Synthesis, antioxidant and antiurease activities of some new 5,6-dichloro-2-(4-fluorobenzyl)-1H-benzimidazolle derivatives containing furan, oxadiazole, triazole and thiadiazole moieties
Bektaş, Hakan; Albay, Canan; Menteşe, Emre; Sökmen, Bahar Bilgin; Kurt, Zafer; Şen, Dilem (Bentham Science Publ Ltd, 2019)Background: Benzimidazoles and its derivatives have been attracting interest for many years because of their biological activities. Benzimidazoles containing different heterocyclic moieties have wide range of biological ... -
Synthesis, antioxidant, and antibacterial activities of some new 2-(3-fluorobenzyl)-1H-benzimidazole derivatives
Bektaş, Hakan; Albay, Canan; Sökmen, Bahar Bilgin; Aydın, Sinem; Menteşe, Emre; Aydın, Gülbahar; Şen, Dilem (Wiley, 2018)A new series of 2-(3-fluorobenzyl)-1H-benzimidazole derivatives containing Schiff base, 1,3,4-oxadiazole, thiosemicarbazide, and 1,3,4-thiadiazole moiety was synthesized. All the synthesized compounds were investigated for ...
