Yazar "Saydam, Faruk" için listeleme
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Akciğer kanserli hastalarda plazma dna metiltransferaz ve metil- CpG'ye bağlanan protein seviyelerinin değerlendirilmesi
Özbayer, Cansu; Üstüner, Derya Akyıldız; Ak, Güntülü Akdoğan; Saydam, Faruk; Metintaş, Muzaffer; Değirmenci, İrfan (2017)Amaç: Akciğer kanseri, akciğer doku hücrelerinin kontrolsüz çoğalmasıyla oluşan ölümcül bir hastalıktır. Çevresel faktörlerle birlikte genetik ve epigenetik değişikliklerin kanser gelişimine neden olduğu bilinmektedir. DNA ... -
Anticancer effects of a novel herbal combination as a potential therapeutic candidate against lung cancer
Saydam, Faruk; Nalkıran, Hatice Sevim (Elsevier Science, 2021)Introduction: Cancer continues to be a prevalent health problem with increasing mortality rates. The interest in complementary medicine for cancer treatment has increased in recent years. In this study, we aimed to investigate ... -
Association and haplotype analysis of the PON1, ITGB3 and CYP3A4 genes, strong candidates for familial coronary artery disease susceptibility
Saydam, Faruk; Değirmenci, İrfan; Birdane, Alparslan; Özbayer, Cansu; Ulus, Taner; Özdemir, Mahmut; Ata, Necmi; Güneş, Hasan Veysi (2023)Objective: Genetic predisposition is very common among the patients with coronary artery disease (CAD), a complex and multifactorial disease. Our objective was to determine the possible association between the most ... -
Association between rs11362 polymorphism in the beta-defensin 1 (DEFB1) gene and dental caries: A meta-analysis
Hatipoğlu, Ömer; Saydam, Faruk (Elsevier, 2020)Objectives: Beta-defensin 1, encoded by the DEFB1 gene, is an important molecule that confers protection from dental caries. Numerous studies have been conducted on the rs11362 polymorphism in the DEFB1 gene. We evaluated ... -
Association between Taql polymorphism of vitamin D receptor gene and vertical growth of the mandible: A cross-sectional study
Objective: To determine whether the gonial angle on digital panoramic radiographs is associated with vitamin D receptor (VDR) Taql polymorphism. Methods: Genomic DNA samples were collected from the buccal mucosa of patients ... -
Association of paraoxonase 1 (PON1) gene polymorphisms and concentration with essential hypertension
Coşan, Didem Turgut; Çolak, Emine; Saydam, Faruk; Yazıcı, Hüseyin uğur; Değirmenci, İrfan; Birdane, Alparslan; Çolak, Ertuğrul; Güneş, Hasan Veysi (Taylor & Francis Inc, 2016)Human serum paraoxonase 1 (PON1) is carried by high-density lipoprotein in blood circulation and is shown to be effective in preventing oxidized phospholipids carried by low-density lipoprotein particles, thus it acts as ... -
Common variants rs3815188 and rs1043994 on notch3 gene confer susceptibility to lung cancer: A hospital-based case-control study
Yağcı, Emine; Değirmenci, İrfan; Özbayer, Cansu; Ak, Güntulu; Saydam, Faruk; Metintaş, Muzaffer (Begell House Inc, 2019)The Notch signaling pathway is a mechanism that plays a role in the determination of cell fate during cell development. Signals between neighbor cells are amplified through the Notch receptors. Notch activity is related ... -
The CYP 2C19*2 and CYP2C19*17 polymorphisms play a vital role in platelet responsiveness to clopidogrel after percutaneous coronary intervention: a pharmacogenomic study
Saydam, Faruk; Değirmenci, İrfan; Birdane, A.; Ozdemir, M.; Ulus, T.; Özbayer, Cansu; Çolak, E.; Ata, N.; Güneş, H.V. (Elsevier, 2015)Background: Clopidogrel inhibits platelet activation and aggregation by blocking the P2Y12 receptor. Dual antiplatelet therapy with clopidogrel and aspirin is recommended treatment by current guidelines for patients ... -
The CYP2C19*2 and CYP2C19*17 polymorphisms play a vital role in clopidogrel responsiveness after percutaneous coronary intervention: A pharmacogenomics study
Saydam, Faruk; Değirmenci, İrfan; Birdane, Alparslan; Özdemir, Mahmut; Ulus, Taner; Özbayer, Cansu; Çolak, Ertuğrul; Ata, Necmi; Güneş, Hasan Veysi (Wiley, 2017)Clopidogrel inhibits platelet activation and aggregation by blocking the P2Y12 receptor. Dual antiplatelet therapy with clopidogrel and aspirin is recommended treatment by current guidelines for patients undergoing ... -
Effect of white tea consumption on serum leptin, TNF-alpha and UCP1 gene expression in ovariectomized rats
Saral, Sinan; Saydam, Faruk; Dokumacıoğlu, Eda; Atak, Mehtap; Tümkaya, Levent; Uydu, Hüseyin Avni (John Libbey Eurotext Ltd., 2021)Background: Obesity and dyslipidemia due to estrogen deficiency are among the important health problems in menopausal women. Increasing evidence reports the anti-obesity and anti-hyperlipidemic properties of tea polyphenols. ... -
The effects of carvacrol on transient receptor potential (TRP) channels in an animal model of parkinson's disease
Akan, Tülay; Aydın, Yasemin; Korkmaz, Tansel; Ulupınar, Emel; Saydam, Faruk (Springer, 2023)In this study, we aimed to investigate the effects of carvacrol (CA), a widely used phytochemical having anti-oxidant and neuroprotective effects, on transient receptor potential (TRP) channels in an animal model of ... -
The effects of monosodium glutamate and tannic acid on adult rats
Çalış, İbrahim Uğur; Coşan, Didem Turgut; Saydam, Faruk; Kolaç, Umut Kerem; Soyocak, Ahu; Kurt, Hülyam; Güneş, Hasan Veysi; Şahintürk, Varol; Mutlu, Fezan Şahin; Köroğlu, Zeynep Özdemir; Değirmenci, İrfan (Kowsar Publ, 2016)Background: Monosodium glutamate (MSG) is a widely-used flavor enhancer and stabilizer in ready-made or packaged foods. the excessive use of MSG has been shown to increase oxidative stress in different organ systems and ... -
Effects of the carbonic anhydrase VI gene polymorphisms on dental caries: A meta-analysis
Hatipoğlu, Ömer; Saydam, Faruk (Polish Dental Soc, 2019)Background. Carbonic anhydrase VI (CA VI) is considered to greatly participate in the buffering of saliva, ion transport, the regulation of pH, secretory processes, and saliva production. Various studies have been conducted ... -
Expression and potential role of miR200b and miR1274a in lung cancer patients
Özbayer, Cansu; Ak, Güntulu Akdoğan; Üstüner, Derya; Saydam, Faruk; Güneş, Hasan Veysi; Metintaş, Muzaffer (Derman Medical Publ, 2017)Aim: Lung cancer (LC) is a fatal disease characterized by uncontrolled proliferation of airway epithelial cells and caused by genetic or environmental factors. LC is one of the most common types of cancer and the leading ... -
Haplotype analyses of CYP2C19*2 and CYP2C19*17 genetic polymorphisms in clopidogrel non-responsiveness after percutaneous coronary intervention with stent implantation
Saydam, Faruk; Değirmenci, İrfan; Birdane, Alparslan; Özdemir, Mahmut; Özbayer, Cansu; Ata, Necmi; Güneş, Hasan Veysi (Nature Publishing Group, 2018).... -
Investigation of the cyp3a4 and pon1 gene variants in turkish patients with familial coronary artery disease
Saydam, Faruk; Değirmenci, İrfan; Birdane, Alparslan; Özdemir, Mahmut; Özbayer, Cansu; Ata, Necmi; Güneş, Hasan Veysi (Lippincott Williams & Wilkins, 2015)Objective: Coronary artery disease (CAD), a complex multifactorial disorder, has been suggested to be associated by the interaction of both environmental and genetic risk factors. -
Is the 1254T > C polymorphism in the DMT1 gene associated with Parkinson's disease?
Saadat, Selva Moheb; Değirmenci, İrfan; Özkan, Serhat; Saydam, Faruk; Köroğlu, Zeynep Özdemir; Çolak, Ertuğrul; Güneş, Hasan Veysi (Elsevier Ireland Ltd, 2015)Parkinson's disease (PD) is a late-onset neurodegenerative disorder with both familial and sporadic presentation. the main pathological characteristic of PD is the death of dopaminergic neurons in the substantia nigra (SN) ... -
Lack of association between enamel formation gene variants and dental caries in adults
Telatar, Gül Yıldız; Saydam, Faruk (Cumhuriyet University Faculty of Dentistry, 2020)Objectives: Studies report that gene polymorphisms associated with mineralization may change the structure of enamel and create a predisposition for developing dental caries. The aim of the study was to evaluate the VDR ... -
miRSNPs of miR1274 and miR3202 genes that target MeCP2 and DNMT3b are associated with lung cancer risk: A study conducted on MassARRAY genotyping
Özbayer, Cansu; Değirmenci, İrfan; Üstüner, Derya; Ak, Güntulu; Saydam, Faruk; Çolak, Ertuğrul; Güneş, Hasan Veysi; Metintaş, Muzaffer (Begell House Inc, 2016)Genetic variants of miRNAs that target DNMTs and MBDs involved in DNA methylation were scanned with current databases, and 35 miRSNPs in 22 miRNA genes were identified. the aim of the study was to determine the association ... -
A promoter polymorphism in the PON1 gene is associated with essential hypertension
Coşan, Didem Turgut; Çolak, Ertuğrul; Saydam, Faruk; Yazıcı, Hüseyin Uğur; Değirmenci, İrfan; Birdane, Alparslan; Güneş, Hüseyin Veysi (Lippincott Williams & Wilkins, 2015)Objective: Increased vascular oxidative stress, the main risk factor of cardiovascular diseases, is seen as a role in the pathophysiology of essential hypertension. Genetic factors also play an important role in the ...
