Yazar "Türkmen Alemdar, Nihal" için listeleme
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Alleviating effect of alpha-pinene on testicular torsion and detorsion injury in rats
Demir, Selim; Kazaz, İlke Onur; Sağnak Yılmaz, Zeynep; Türkmen Alemdar, Nihal; Ayazoğlu Demir, Elif; Tepe, Recep Serhat; Menteşe, Ahmet (Galenos Yayınevi, 2023)Objective: It was aimed to evaluate whether alpha-pinene (AP) had a beneficial effect in the testicular ischemia/reperfusion injury (IRI) model for the first time. Materials and Methods: Testicular malondialdehyde, total ... -
Alpha-pinene neutralizes cisplatin-induced reproductive toxicity in male rats through activation of Nrf2 pathway
Demir, Selim; Menteşe, Ahmet; Türkmen Usta, Zeynep; Türkmen Alemdar, Nihal; Ayazoğlu Demir, Elif; Aliyazıcıoğlu, Yüksel (Springer, 2023)Purpose Testicular toxicity is one of the most important side efects of cisplatin (CP) therapy. Alpha-pinene (AP) is a naturally occurring monoterpene with antioxidant character in plants. Here, we aimed to evaluate the ... -
Ameliorative effect of gallic acid on cisplatin-induced ovarian toxicity in rats
Ayazoğlu Demir, Elif; Menteşe, Ahmet; Livaoğlu, Ayten; Türkmen Alemdar, Nihal; Demir, Selim (Taylor & Francis Ltd., 2021)The aim of the present study was to evaluate the protective effect of gallic acid (GA) against cisplatin (CDDP)-induced ovarian toxicity, for the first time. The ovarian damage was generated with CDDP (5 mg/kg) intraperitoneally ... -
The ameliorative effect of Primula vulgaris on cisplatin-induced nephrotoxicity in rats and quantification of its phenolic components using LC-ESI-MS/MS
Turan, İbrahim; Canbolat, Deniz; Demir, Selim; Kerimoğlu, Gökçen; Çolak, Fatih; Türkmen Alemdar, Nihal; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)Cisplatin (CDDP) is an important chemotherapeutic agent, accumulation of which in kidney tissue causes nephrotoxicity and renal failure. The aim of this study was to evaluate, for the first time in the literature, the ... -
Chlorogenic acid ameliorates torsion/detorsion-induced testicular injury via decreasing endoplasmic reticulum stress
Kazaz, İlke Onur; Demir, Selim; Kerimoğlu, Gökçen; Çolak, Fatih; Türkmen Alemdar, Nihal; Doğan, Sedanur Yılmaz; Bostan, Serdar; Menteşe, Ahmet (Elsevier, 2022)Backround Testicular torsion (TT) is an urological emergency situation especially in adolescents and young men. The main pathophysiology of testicular torsion/detorsion (T/D) is ischemia-reperfusion (I/R) injury. I/R ... -
Evaluation of the therapeutic effects of arbutin on cisplatin-induced ovarian toxicity in rats through endoplasmic reticulum stress and Nrf2 pathway
Ayazoğlu Demir, Elif; Menteşe, Ahmet; Yılmaz, Zeynep Sağnak; Türkmen Alemdar, Nihal; Demir, Selim; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)Arbutin (ARB) is a glycosylated hydroquinone with potent antioxidant effects. Although cisplatin (CP) is widely used in chemotherapy, its toxicity in healthy tissues, including ovotoxicity, is an insurmountable problem. ... -
Gentisic acid ameliorates cisplatin-induced reprotoxicity through suppressing endoplasmic reticulum stress and upregulating Nrf2 pathway
Menteşe, Ahmet; Demir, Selim; Aydın Mungan, Sevdegül; Alemdar, Nihal Türkmen; Ayazoğlu Demir, Elif; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)Reproductive toxicity is a serious side effect of cisplatin (CP) chemotherapy. Gentisic acid (GTA) is a phenolic acid with strong antioxidant properties. Here, we aimed to determine therapeutic effect of GTA against ... -
p-Coumaric acid alleviates cisplatin-induced ovarian toxicity in rats
Ayazoğlu Demir, Elif; Menteşe, Ahmet; Küçük, Hatice; Türkmen Alemdar, Nihal; Demir, Selim (Wiley, 2021)Objective The therapeutic value of cisplatin (CDDP) as an anticancer drug is limited by its ovo-otoxicity. The effect of natural phenolic acids in the prevention of many diseases related to oxidative stress has been reported. ... -
Suppression of cisplatin-induced ovarian injury in rats by chrysin: an experimental study
Menteşe, Ahmet; Türkmen Alemdar, Nihal; Livaoğlu, Ayten; Demir, Elif Ayazoğlu; Aliyazıcıoğlu, Yüksel; Demir, Selim (Taylor & Francis Ltd., 2022)The aim of this study was to investigate the potential therapeutic efficacy of chrysin (CHS) against ovotoxicity caused by intraperitoneal administration of cisplatin (CDDP) in rats. In this experimental study, 24 female ... -
Therapeutic effect of berberine against 5-fluorouracil induced ovarian toxicity in rats
Demir, Selim; Türkmen Alemdar, Nihal; Küçük, Hatice; Ayazoğlu Demir, Elif; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Taylor & Francis Ltd., 2024)Berberine (BER) is a naturally occurring alkaloid with a multitude of beneficial effects on human health. Although it is one of the most studied phytochemicals, its curative effect against ovarian damage caused by ...
