Yazar "Tatar Yılmaz, Gizem" için listeleme
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Design, synthesis, molecular modeling, in vitro evaluation of novel piperidine-containing hydrazone derivatives as cholinesterase inhibitors
Tok, Fatih; Baltaş, Nimet; Abas, Burçin İrem; Tatar Yılmaz, Gizem; Kaya, Süleyman; Koçyiğit-Kaymakçıoğlu, Bedia; Çevik, Özge (Wiley, 2024)In an effort to develop new and effective therapeutic agents for Alzheimer's disease, a series of hydrazone derivatives bearing piperidine rings have been designed and synthesized. The chemical structures of the compounds ... -
Evaluation of synthesized methoxy chalcones for therapeutic potential through in vitro and in silico methods
Erik, Zeynep; Erik, İshak; Yalçın, Can Özgür; Şener, Sıla Özlem; Karaoğlu, Şengül Alpay; Tatar Yılmaz, Gizem; Yaylı, Nurettin; Aliyazıcıoğlu, Rezzan (Marmara University, 2025)Chalcones are the precursors of flavonoids and have a wide range of biological activities. A series of methoxy chalcones (1-12) were synthesized using the Claisen-Schmidt method and identified by NMR analyses. Enzyme ... -
Synthesis of novel thiosemicarbazone derivatives as antidiabetic agent with enzyme kinetic studies and antioxidant activity
Tok, Fatih; Küçükal, Bahar; Baltaş, Nimet; Tatar Yılmaz, Gizem; Koçyiğit Kaymakçıoğlu, Bedia (Taylor & Francis Ltd., 2022)Novel thiosemicarbazone derivatives were synthesized via condensation reactions between the corresponding thiosemicarbazides and 4-(methylsulfonyl)acetophenone. The chemical structures of all compounds were elucidated by ... -
Synthesis, antimicrobial activities, and molecular modeling studies of agents for the sortase a enzyme
Tatar Yılmaz, Gizem; Yaylı, Nurettin; Tüzüner, Tamer; Bozdal, Gözde; Salmanlı, Merve; Renda, Gülin; Korkmaz, Büşra; Bozdeveci, Arif; Alpay Karaoğlu, Şengül (Wiley, 2024)Sortase A (SrtA) is an attractive target for developing new anti-infective drugs that aim to interfere with essential virulence mechanisms, such as adhesion to host cells and biofilm formation. Herein, twenty hydroxy, ...
