Yazar "Yapca, Ömer Erkan" için listeleme
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Benefits of the antioxidant and anti-inflammatory activity of etoricoxib in the prevention of ovarian ischemia/reperfusion injury induced experimentally in rats
Yapca, Ömer Erkan; Turan, Mehmet İbrahim; Yılmaz, İsmayil; Salman, Süleyman; Gülaboğlu, Mine; Süleyman, Halis (Wiley-Blackwell, 2014)Aim This study is a biochemical investigation of the effect of etoricoxib, a selective cyclooxygenase (COX)-2 inhibitor, on ischemia/reperfusion (I/R) injury experimentally induced in rat ovaries. Methods Experimental ... -
Bilateral ovarian ischemia/reperfusion injury and treatment options in rats with an induced model of diabetes
Yapca, Ömer Erkan; Turan, Mehmet İbrahim; Börekçi, Bünyamin; Akçay, Fatih; Süleyman, Halis (Mashhad Univ Med Sciences, 2014)Objective(s): This study investigated the effects of melatonin, famotidine, mirtazapine, and thiamine pyrophosphate on ischemia/ reperfusion (I/ R) injury in diabetic rats and evaluated oxidant and antioxidant marker ... -
Controlled reperfusion for different durations in the treatment of ischemia-reperfusion injury of the rat ovary: evaluation of biochemical features, molecular gene expression, and histopathology
Yapca, Ömer Erkan; Kumbasar, Serkan; Salman, Süleyman; Yaralı, Oğuzhan; Şener, Ebru; Mammadov, Renad; Tekin, Yeşim Bayoğlu; Aksoy, Ayşenur; Albayrak, Abdulmecit; Çetin, Nihal (Canadian Science Publishing, Nrc Research Press, 2015)High numbers of proinflammatory cells (PMNLs), which are carried by the blood to ischemic tissue during reperfusion, are considered responsible for inducing the inflammatory response that occurs in ischemia-reperfusion ... -
The effect of mirtazapine on cisplatin-induced oxidative damage and infertility in rat ovaries
Altuner, Durdu; Gülaboğlu, Mine; Yapca, Ömer Erkan; Çetin, Nihal (Hindawi Ltd, 2013)Cisplatin causes infertility due to ovarian toxicity. the toxicity mechanism is unknown, but evidence suggests oxidative stress. in this study, the effect of mirtazapine on cisplatin-induced infertility and oxidative stress ... -
Exogenous ATP administration prevents ischemia/reperfusion-induced oxidative stress and tissue injury by modulation of hypoxanthine metabolic pathway in rat ovary
Kumbasar, Serkan; Çetin, Nihal; Yapca, Ömer Erkan; Şener, Ebru; İsaoğlu, Ünal; Yılmaz, Mehmet; Salman, Süleyman; Aksoy, Ayşe Nur; Gül, Mehmet Ali; Süleyman, Halis (Univ Federal Santa Maria, 2014)In this study, xanthine oxidase (XO), malondialdehyde (MDA), myeloperoxidase (MPO) and glutathione (GSH) levels in the ovarian tissues of rats during the development of ischemia and postischemia-induced reperfusion were ... -
The impaired balances of oxidant/antioxidant and COX-1/COX-2 in ovarian ischemia-reperfusion injury and prevention by Nimesulide
İsaoğlu, Ünal; Yılmaz, Mehmet; Şener, Ebru; Çetin, Nihal; Altuner, Durdu; Bilen, Habib; Yapca, Ömer Erkan; Demiryılmaz, İsmail; İsaoğlu, Neslihan; Gül, Mehmet Ali; Kumbasar, Serkan; Süleyman, Halis (Colegio Farmaceuticos Provincia de Buenos Aires, 2012)The aims of this study were to investigate the association of ovarian I/R injury with oxidant/antioxidant and cyclooxygenase activity and to examine the effect of nimesulide in I/R injury. Rats were divided into four groups: ... -
Investigation and histopathological evaluation of the effects of omeprazole on the ischemia-reperfusion induced oxidative damage and DNA mutation in rat ovarian tissue
Demiryılmaz, İsmail; Çetin, Nihal; Yapca, Ömer Erkan; Altuner, Durdu; İsaoğlu, Ünal; Özgeris, Fatma Betül; Çalık, Muhammet; Süleyman, Halis (Chemical Publishing Co., 2013)In this study, the biochemical and histopathological effects of omeprazole on ischemia-reperfusion (I/R) induced oxidative damage in rat ovarian tissue were investigated. The moment that the animals remained motionless in ... -
Synthesis and biological evaluation of novel benzylidene thiazolo pyrimidin-3(5H)-one derivatives
Akbaş, Esvet; Othman, Khdir A.; Çelikezen, Fatih Çağlar; Aydoğan Ejder, Nebahat; Türkez, Hasan; Yapca, Ömer Erkan; Mardinoğlu, Adil (Taylor & Francis Ltd., 2023)Starting compound 1 was synthesized according to reference. 1 Benzylidene thiazole pyrimidin-3(5H)-ones were synthesized reactions of 1 with bromoacetic acid and various aryl-aldehydes in the same vessel via one-step, ... -
Synthesis, characterization, theoretical studies and in vitro embriyotoxic, genotoxic and anticancer effects of novel phenyl(1,4,6-triphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl) methanone
Akbaş, Esvet; Othman, Khdir A.; Çelikezen, Fatih Çağlar; Ejder, Nebahat Aydoğan; Türkez, Hasan; Yapca, Ömer Erkan; Mardinoğlu, Adil (Taylor & Francis L.T.D., 2023)In this study, phenyl (1,4,6-triphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methanone was obtained by using the Biginelli reaction method. The structure of this compound was analyzed using elemental analysis, IR, 1H, ...
