dc.contributor.author | Pergel, Ahmet | |
dc.contributor.author | Tümkaya, Levent | |
dc.contributor.author | Demiral, Gökhan | |
dc.contributor.author | Çolakoğlu, Muhammet Kadri | |
dc.contributor.author | Kalcan, Süleyman | |
dc.contributor.author | Özdemir, Ali | |
dc.contributor.author | Mercantepe, Tolga | |
dc.contributor.author | Erdivanlı, Başar | |
dc.contributor.author | Yılmaz, Adnan | |
dc.date.accessioned | 2020-12-19T19:34:43Z | |
dc.date.available | 2020-12-19T19:34:43Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Pergel, A., Tümkaya, L., Demiral, G., Çolakoğlu, M. K., Kalcan, S., Özdemir, A., Mercantepe, T., Erdivanlı, B., & Yılmaz, A. (2020). The protective effects of adalimumab on intestinal injury induced with infrarenal aortic occlusion. İnfrarenal aort oklüzyonu ile oluşan intestinal hasarında adalimumab'ın koruyucu etkisi. Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 26(3), 366–372. https://doi.org/10.14744/tjtes.2019.59607 | en_US |
dc.identifier.issn | 1306-696X | |
dc.identifier.uri | https://doi.org/10.14744/tjtes.2019.59607 | |
dc.identifier.uri | https://hdl.handle.net/11436/1152 | |
dc.description | mercantepe, tolga/0000-0002-8506-1755 | en_US |
dc.description | WOS: 000536020600005 | en_US |
dc.description | PubMed: 32436975 | en_US |
dc.description.abstract | BACKGROUND: the present study aims to observe the effects of ischemia-reperfusion (IR) on small intestines at a molecular level and to prospectively assess the potential preventive role of adalimumab (ADA) and antioxidants. METHODS: A total of 24 male Sprague-Dawley rats were randomly divided into three groups-a control group, an IR group and an IR+ADA group. RESULTS: Although there was no change in SOD levels in the small bowel tissue of the IR group, we observed increased malondialdehyde (MDA) levels and increased numerical density of caspase-3 and TNF-alpha positive enterocytes p=0.00 and p=0.00, respectively). We also observed that IR caused the degeneration of villus crypt structures. CONCLUSION: We found that ADA treatment reduced MDA levels and decreased the numerical density of caspase-3 and TNF-a positive enterocytes compared to the IR group (p=0.00; p=0.011; p=0.00, respectively). We conclude that ADA can be beneficial in preventing intestinal injury that arises from IR. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Turkish Assoc Trauma Emergency Surgery | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Adalimumab | en_US |
dc.subject | Intestinal injury | en_US |
dc.subject | Ischemia | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Rat | en_US |
dc.subject | Reperfusion | en_US |
dc.title | The protective effects of adalimumab on intestinal injury induced with infrarenal aortic occlusion | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Pergel, Ahmet | |
dc.contributor.institutionauthor | Tümkaya, Levent | |
dc.contributor.institutionauthor | Demiral, Gökhan | |
dc.contributor.institutionauthor | Çolakoğlu, Muhammet Kadri | |
dc.contributor.institutionauthor | Kalcan, Süleyman | |
dc.contributor.institutionauthor | Özdemir, Ali | |
dc.contributor.institutionauthor | Mercantepe, Tolga | |
dc.contributor.institutionauthor | Erdivanlı, Başar | |
dc.contributor.institutionauthor | Yılmaz, Adnan | |
dc.identifier.doi | 10.14744/tjtes.2019.59607 | |
dc.identifier.volume | 26 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 366 | en_US |
dc.identifier.endpage | 372 | en_US |
dc.ri.edit | oa | en_US |
dc.relation.journal | Ulusal Travma ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgery | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |