dc.contributor.author | Tural, Keyser | |
dc.contributor.author | Özden, Özkan | |
dc.contributor.author | Bilgi, Zeynep | |
dc.contributor.author | Kubat, Emre | |
dc.contributor.author | Ermutlu, Celal Şahin | |
dc.contributor.author | Merhan, Oğuz | |
dc.contributor.author | Güvendi, Gülname Fındık | |
dc.contributor.author | Küçüker, S.A. | |
dc.date.accessioned | 2020-12-19T19:35:28Z | |
dc.date.available | 2020-12-19T19:35:28Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Tural, K., Ozden, O., Bilgi, Z., Kubat, E., Ermutlu, C. S., Merhan, O., Findik Guvendi, K., & Kucuker, S. A. (2020). The protective effect of betanin and copper on heart and lung in end‑organ ischemia reperfusion injury. Bratislavske lekarske listy, 121(3), 211–217. https://doi.org/10.4149/BLL_2020_032 | en_US |
dc.identifier.issn | 0006-9248 | |
dc.identifier.issn | 1336-0345 | |
dc.identifier.uri | https://doi.org/10.4149/BLL_2020_032 | |
dc.identifier.uri | https://hdl.handle.net/11436/1297 | |
dc.description | bilgi, zeynep/0000-0003-4981-047X | en_US |
dc.description | WOS: 000528258200007 | en_US |
dc.description | PubMed: 32115979 | en_US |
dc.description.abstract | OBJECTIVES: Betanin and copper sulphate have been previously indicated as beneficial agents for ischemia/reperfusion (I/R) as antioxidant compounds in various models. We investigated whether betanin and copper have any protective effects on the heart and lung against I/R injury in rats. METHODS: Spraque-Dawley rats were assigned in groups: Sham (laparotomy only), control (I/R only), betanin treatment (100 mg/kg of betanin administered intraperitoneally (i.p.) 60 minutes before I/R) and copper sulfate treatment group (0.1 mg/kg/day copper sulfate i.p. for 7 days before I/R). Ischemia was induced by clamping the aorta between the left renal artery and aortic bifurcation for 45 minutes. After 48-hour reperfusion, the rats were sacrificed and heart/lung tissues were harvested. Malondialdehyde (MDA), myeloperoxidase (MPO), interleukin 6 (IL-6) levels were determined. Apoptosis was determined via TUNEL assay. RESULTS: MDA, MPO, IL-6 levels and apoptotic cells were significantly increased in the I/R group. in both treatment groups, MDA and MPO levels were decreased. IL-6 was significantly decreased in response to betanin administration in the heart, but not in the lung; copper had no effect in either area. the numbers of apoptotic cells were significantly decreased in both treatment groups. CONCLUSION: Betanin and copper may have protective effects on I/R injury in the heart and lung in rats (Fig. 6, Ref. 39). | en_US |
dc.description.sponsorship | Kafkas University BAPKafkas University [2017-TS-14] | en_US |
dc.description.sponsorship | This work was supported by Kafkas University BAP #2017-TS-14. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Comenius Univ | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Ischemia reperfusion injury | en_US |
dc.subject | Betanin | en_US |
dc.subject | Copper | en_US |
dc.subject | Antiinflammation | en_US |
dc.subject | Antioxidant | en_US |
dc.subject | Rat | en_US |
dc.title | The protective effect of betanin and copper on heart and lung in end-organ ischemia reperfusion injury | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Güvendi, Gülname Fındık | |
dc.identifier.doi | 10.4149/BLL_2020_032 | |
dc.identifier.volume | 121 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 211 | en_US |
dc.identifier.endpage | 217 | en_US |
dc.ri.edit | oa | en_US |
dc.relation.journal | Bratislava Medical Journal-Bratislavske Lekarske Listy | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |