dc.contributor.author | Duman, Hakan | |
dc.contributor.author | Özyurt, Songül | |
dc.contributor.author | Erdoğan, Turan | |
dc.contributor.author | Kara, Bilge Yılmaz | |
dc.contributor.author | Durakoğlugil, Murtaza Emre | |
dc.date.accessioned | 2020-12-19T19:36:17Z | |
dc.date.available | 2020-12-19T19:36:17Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Duman, H., Özyurt, S., Erdoğan, T., Kara, B. Y., & Durakoğlugil, M. E. (2019). The role of serum bilirubin levels in determining venous thromboembolism. Journal of vascular surgery. Venous and lymphatic disorders, 7(5), 635–639. https://doi.org/10.1016/j.jvsv.2019.02.002 | en_US |
dc.identifier.issn | 2213-333X | |
dc.identifier.uri | https://doi.org/10.1016/j.jvsv.2019.02.002 | |
dc.identifier.uri | https://hdl.handle.net/11436/1418 | |
dc.description | duman, hakan/0000-0002-1441-7320 | en_US |
dc.description | WOS: 000491548200004 | en_US |
dc.description | PubMed: 30922986 | en_US |
dc.description.abstract | Objective: Venous thromboembolism (VTE) is a disease that includes both deep venous thrombosis (DVT) and pulmonary embolism (PE). Bilirubin is an endogenous anti-inflammatory marker associated with atherothrombosis. the purpose of our study was to investigate the association of serum bilirubin levels with the presence of VTE. Methods: A total of 103 patients with VTE (distal DVT, n = 34; proximal DVT, n = 30; PE, n = 39) and 50 control patients were cross-sectionally enrolled. Peripheral venous duplex ultrasound and computed tomography were used for the diagnosis of VTE. Fasting blood samples were drawn for biochemical analyses. Results: Baseline characteristics were not different between groups. the VTE group had lower bilirubin level (9.0 +/- 2.6 mu mol/L vs 7.3 +/- 3 mu mol/L; P = .001) and higher high-sensitivity C-reactive protein (hs-CRP) concentration (0.8 [0.3-2] mg/L vs 1.1 [0.2-3] mg/L; P = .008) and white blood cell count (7.4 +/- 1.5 x 10(9)/L vs 8.2 +/- 2.7 x 10(9)/L; P = .02) compared with control patients. in the analysis of variance, the levels of total direct bilirubin and hs-CRP were clearly different between the control group and VTE subgroups (distal and proximal DVT and PE). the receiver operating characteristic curve analysis showed a cutoff value of 8.9 mu mol/L for total bilirubin (sensitivity, 74%; specificity, 55%) and an area under the curve of 0.659 (P < .001). Conclusions: Bilirubin level, hs-CRP concentration, and white blood cell count were independently associated with VTE. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Thromboembolism | en_US |
dc.subject | Bilirubin | en_US |
dc.subject | Pulmonary embolism | en_US |
dc.subject | Antioxidant | en_US |
dc.title | The role of serum bilirubin levels in determining venous thromboembolism | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Duman, Hakan | |
dc.contributor.institutionauthor | Özyurt, Songül | |
dc.contributor.institutionauthor | Erdoğan, Turan | |
dc.contributor.institutionauthor | Kara, Bilge Yılmaz | |
dc.contributor.institutionauthor | Durakoğlugil, Murtaza Emre | |
dc.identifier.doi | 10.1016/j.jvsv.2019.02.002 | |
dc.identifier.volume | 7 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 635 | en_US |
dc.identifier.endpage | 639 | en_US |
dc.relation.journal | Journal of Vascular Surgery-Venous and Lymphatic Disorders | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |