| dc.contributor.author | Mermer, Arif | |
| dc.contributor.author | Bayrak, Hacer | |
| dc.contributor.author | Şirin, Yakup | |
| dc.contributor.author | Emirik, Mustafa | |
| dc.contributor.author | Demirbaş, Neslihan | |
| dc.date.accessioned | 2020-12-19T19:36:34Z | |
| dc.date.available | 2020-12-19T19:36:34Z | |
| dc.date.issued | 2019 | |
| dc.identifier.citation | Mermer, A., Bayrak, H., Şirin, Y., Emirik, M. & Demirbaş, N. (2019). Synthesis of novel Azol-beta-lactam derivatives starting from phenyl piperazine and investigation of their antiurease activity and antioxidant capacity comparing with their molecular docking studies. Journal of Molecular Structure, 1189, 279-287. https://doi.org/10.1016/j.molstruc.2019.04.039 | en_US |
| dc.identifier.issn | 0022-2860 | |
| dc.identifier.issn | 1872-8014 | |
| dc.identifier.uri | https://doi.org/10.1016/j.molstruc.2019.04.039 | |
| dc.identifier.uri | https://hdl.handle.net/11436/1451 | |
| dc.description | emirik, mustafa/0000-0001-9489-9093; BAYRAK, Hacer/0000-0001-5843-8716; Mermer, Arif/0000-0002-4789-7180 | en_US |
| dc.description | WOS: 000466710300033 | en_US |
| dc.description.abstract | This study reports the synthesis, biological investigation and molecular docking of novel beta-lactam derivatives bearing 1,3,4-thiadiazole and 1,3,4-oxadiazole ring system. the synthesized compounds were evaluated for in vitro antiurease activity and antioxidant capacity. Almost all compounds showed excellent antiurease activity compared to thiourea, standard drug. Also, in silico ADME (absorption, distribution, metabolism, elimination) prediction and molecular docking studies were performed. (C) 2019 Elsevier B.V. All rights reserved. | en_US |
| dc.description.sponsorship | Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [115Z770] | en_US |
| dc.description.sponsorship | The support was provided by Scientific and Technological Research Council of Turkey (TUBITAK, No. 115Z770). | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Elsevier Science Bv | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Azole | en_US |
| dc.subject | Phenyl piperazine | en_US |
| dc.subject | beta-Lactam | en_US |
| dc.subject | Antioxidant capacity | en_US |
| dc.subject | Antiurease activity | en_US |
| dc.subject | Molecular docking | en_US |
| dc.title | Synthesis of novel Azol-beta-lactam derivatives starting from phenyl piperazine and investigation of their antiurease activity and antioxidant capacity comparing with their molecular docking studies | en_US |
| dc.type | article | en_US |
| dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
| dc.contributor.institutionauthor | Emirik, Mustafa | |
| dc.identifier.doi | 10.1016/j.molstruc.2019.04.039 | |
| dc.identifier.volume | 1189 | en_US |
| dc.identifier.startpage | 279 | en_US |
| dc.identifier.endpage | 287 | en_US |
| dc.relation.journal | Journal of Molecular Structure | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
