dc.contributor.author | Taflan, Ebru | |
dc.contributor.author | Bayrak, Hacer | |
dc.contributor.author | Er, Mehtap | |
dc.contributor.author | Karaoğlu, Şengül Alpay | |
dc.contributor.author | Bozdeveci, Arif | |
dc.date.accessioned | 2020-12-19T19:36:41Z | |
dc.date.available | 2020-12-19T19:36:41Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Taflan, E., Bayrak, H., Er, M., Alpay Karaoğlu, Ş., & Bozdeveci, A. (2019). Novel imidazo[2,1-b][1,3,4]thiadiazole (ITD) hybrid compounds: Design, synthesis, efficient antibacterial activity and antioxidant effects. Bioorganic chemistry, 89, 102998. https://doi.org/10.1016/j.bioorg.2019.102998 | en_US |
dc.identifier.issn | 0045-2068 | |
dc.identifier.issn | 1090-2120 | |
dc.identifier.uri | https://doi.org/10.1016/j.bioorg.2019.102998 | |
dc.identifier.uri | https://hdl.handle.net/11436/1468 | |
dc.description | Alpay Karaoglu, Sengul/0000-0003-1047-8350; BOZDEVECI, ARIF/0000-0002-0729-9143 | en_US |
dc.description | WOS: 000476615700032 | en_US |
dc.description | PubMed: 31128819 | en_US |
dc.description.abstract | In this study, novel imidazo[2,1-b] [1,3,4]thiadiazole (ITD) compounds were synthesized and their antimicrobial and antioxidant capacity was examined. the C-2 position of the ITD structure was fixed with the 3,4-hydroxybenzene ring and the properties of the two series of compounds obtained by phenyl or 4-chlorophenyl in the C-6 position were compared. in the formation of these series, new properties were determined by the addition of different pharmacophore to the target product by binding of the groups known in the literature from the C-5 position to the structure. in the study, it was seen that the compounds 4a, 4b, 5a, 5b, 7f, 10, 12 and 13 had very high anti-tuberculosis activities at low concentrations, 3b was found to exhibit moderate activity while other synthesis compounds exhibited moderate activity. in addition, it showed activity against gram positive and negative bacteria. in the determination of the antioxidant capacities of the newly synthesized compounds by FRAP and DPPH methods, the compounds showing activity were found to be 2, 3a, 3b, 6c, 9, 11 and 13. the structures of all synthesized compounds were solved by spectroscopic methods such as FT-IR, H-1 NMR, C-13 NMR and mass. | en_US |
dc.description.sponsorship | Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [117Z422] | en_US |
dc.description.sponsorship | This work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) [grant number 117Z422]. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Academic Press Inc Elsevier Science | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Imidazo [2,1-b] [1,3,4] thiadiazole | en_US |
dc.subject | 1,3-thiazolidin-4-one | en_US |
dc.subject | Antimicrobial activity | en_US |
dc.subject | Antioxidant activity | en_US |
dc.subject | Mannich bases | en_US |
dc.title | Novel imidazo[2,1-b] [1,3,4]thiadiazole (ITD) hybrid compounds: Design, synthesis, efficient antibacterial activity and antioxidant effects | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Biyoloji Bölümü | en_US |
dc.contributor.institutionauthor | Karaoğlu, Şengül Alpay | |
dc.contributor.institutionauthor | Bozdeveci, Arif | |
dc.identifier.doi | 10.1016/j.bioorg.2019.102998 | |
dc.identifier.volume | 89 | en_US |
dc.relation.journal | Bioorganic Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |