Changes in serum valproate and levetiracetam levels related to sex steroids in adolescent girls

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Date

2019

Author

Şahin, Sevim
Yılmaz, Semra Atasoy
Cansu, Ali
Kamasak, Tülay
Arslan, Elif Acar
Kaklikkaya, Neşe

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Şahin, S., Yılmaz, S. A., Cansu, A., Kamaşak, T., Arslan, E. A., & Kaklıkkaya, N. (2019). Changes in Serum Valproate and Levetiracetam Levels Related to Sex Steroids in Adolescent Girls. Pediatric neurology, 96, 76–78. https://doi.org/10.1016/j.pediatrneurol.2019.03.010

Abstract

In girls with epilepsy, two problems arise after adolescence. First, valproate (VPA), a commonly used antiepileptic drug (AED) in childhood, has been associated with polycystic ovarian changes and reproductive endocrine disorders.1 Increased body weight with VPA has been suggested as a risk for polycystic ovary syndrome.

Source

Pediatric Neurology

Volume

96

URI

https://doi.org/10.1016/j.pediatrneurol.2019.03.010
https://hdl.handle.net/11436/1501

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