A convenient method for the synthesis of 3,4-dihydroquinazolines from iminoester hydrochlorides via microwave irradiation

Abstract

This is work presents a simple and practical strategy for the synthesis of 2-substituted-3,4-dihydroquinazolines in which the ring closure reaction of 2-aminobenzylamine with corresponding iminoester hydrochlorides via microwave irradiation allows the formation of the target compounds. Also, the 3,4-quinazoline derivatives were synthesized by conventional heating procedures for comparison in terms of reaction time and yield.