dc.contributor.author | Karaali, Nesrin | |
dc.contributor.author | Menteşe, Meltem | |
dc.contributor.author | Baltaş, Nimet | |
dc.contributor.author | Menteşe, Emre | |
dc.date.accessioned | 2020-12-19T19:41:07Z | |
dc.date.available | 2020-12-19T19:41:07Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Karaali, N., Menteşe, E., Baltaş, N. & Menteşe, E. (2018). Synthesis and Urease Inhibition Study of Some New Quinazolinone Derivatives Bearing Triazole, Thiadiazole, and Piperazine Moiety. Journal of Heterocyclic Chemistry, 55(11), 2571-2577. https://doi.org/10.1002/jhet.3313 | en_US |
dc.identifier.issn | 0022-152X | |
dc.identifier.issn | 1943-5193 | |
dc.identifier.uri | https://doi.org/10.1002/jhet.3313 | |
dc.identifier.uri | https://hdl.handle.net/11436/1729 | |
dc.description | WOS: 000450023400011 | en_US |
dc.description.abstract | A new series of 2,3-disubstituted quinazolin-4(3H)-one derivatives bearing triazole and thiadiazole nucleus has been synthesized and then screened for their urease inhibition properties. All synthesized compounds showed outstanding urease inhibitory potentials with IC50 values ranging between 0.25 +/- 0.01 and 18.00 +/- 0.64 mu g/mL when compared with standard inhibitors thiourea (IC50 = 15.08 +/- 0.71 mu g/mL) and acetohydroxamic acid (IC50 = 21.05 +/- 0.96 mu g/mL). All new molecules were characterized by H-1 NMR, C-13 NMR, and MS. | en_US |
dc.description.sponsorship | Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [115Z885]; TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) | en_US |
dc.description.sponsorship | This work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) under the project number of 115Z885. the authors gratefully thank TUBITAK for financial support. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Moleculer docking | en_US |
dc.subject | Pharmological evaluatioan | en_US |
dc.subject | Biological evaluation | en_US |
dc.title | Synthesis and urease inhibition study of some new quinazolinone derivatives bearing triazole, thiadiazole, and piperazine moiety | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Karaali, Nesrin | |
dc.contributor.institutionauthor | Menteşe, Meltem | |
dc.contributor.institutionauthor | Baltaş, Nimet | |
dc.contributor.institutionauthor | Menteşe, Emre | |
dc.identifier.doi | 10.1002/jhet.3313 | |
dc.identifier.volume | 55 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.startpage | 2571 | en_US |
dc.identifier.endpage | 2577 | en_US |
dc.relation.journal | Journal of Heterocyclic Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |