dc.contributor.author | Bedir, Recep | |
dc.contributor.author | Tümkaya, Levent | |
dc.contributor.author | Mercantepe, Tolga | |
dc.contributor.author | Yılmaz, Adnan | |
dc.date.accessioned | 2020-12-19T19:41:11Z | |
dc.date.available | 2020-12-19T19:41:11Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Bedir, R., Tumkaya, L., Mercantepe, T., & Yilmaz, A. (2018). Pathological Findings Observed in the Kidneys of Postnatal Male Rats Exposed to the 2100 MHz Electromagnetic Field. Archives of medical research, 49(7), 432–440. https://doi.org/10.1016/j.arcmed.2018.12.010 | en_US |
dc.identifier.issn | 0188-4409 | |
dc.identifier.issn | 1873-5487 | |
dc.identifier.uri | https://doi.org/10.1016/j.arcmed.2018.12.010 | |
dc.identifier.uri | https://hdl.handle.net/11436/1741 | |
dc.description | Mercantepe, Tolga/0000-0002-8506-1755 | en_US |
dc.description | WOS: 000466058100003 | en_US |
dc.description | PubMed: 30600117 | en_US |
dc.description.abstract | Background. the widespread use by young people of modern communication devices such as mobile phones means that they are particularly exposed to electromagnetic fields (EMF) and other problems. However, few studies have researched the effects of long-term exposure to EMF in the kidney. We therefore investigated oxidative stress and apoptosis in long-term exposure to 2100 megahertz (MHz) in a rat model. Materials and Methods. Twenty-four Sprague Dawley rats were divided into a control group (n = 8, no EMF exposure), a group exposed to 2100 MHz for 6 h for 30 d (n = 8), and a group exposed to 2100 MHz for 12 h for 30 d (n = 8). Immunohistochemical analysis was performed, using caspase-3 to evaluate apoptosis. Immediately after treatment, reduced glutathione (GSH), malondialdehyde (MDA) in kidney tissue and serum levels of various biochemical compounds were measured to detect oxidative stress. Results. Deterioration was observed in the brush border in renal tubules of the EMF groups. the results of the immunohistochemical analysis revealed a greater number of positively stained renal tubular epithelial cells in the EMF groups as compared with that in the control group. in the EMF groups, renal MDA levels increased, and renal GSH levels decreased compared with those in the control group, as shown by a biochemical examination (p = 0.00 and p = 0.00, respectively). Conclusion. the findings showed that exposure to 2100 MHz for 6 and 12 h induced oxidative stress-mediated acute renal injury, depending on the length of exposure and dosage. (C) 2018 IMSS. Published by Elsevier Inc. | en_US |
dc.description.sponsorship | Recep Tayyip Erdogan University Scientific Research Support Fund [2017-787] | en_US |
dc.description.sponsorship | This work was supported by the Recep Tayyip Erdogan University Scientific Research Support Fund under Grant [2017-787]. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Science Inc | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Caspase-3 | en_US |
dc.subject | Electromagnetic field | en_US |
dc.subject | Kidney | en_US |
dc.subject | Oxidative stress | en_US |
dc.title | Pathological findings observed in the kidneys of postnatal male rats exposed to the 2100 MHz electromagnetic field | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Bedir, Recep | |
dc.contributor.institutionauthor | Tümkaya, Levent | |
dc.contributor.institutionauthor | Mercantepe, Tolga | |
dc.contributor.institutionauthor | Yılmaz, Adnan | |
dc.identifier.doi | 10.1016/j.arcmed.2018.12.010 | |
dc.identifier.volume | 49 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.startpage | 432 | en_US |
dc.identifier.endpage | 440 | en_US |
dc.relation.journal | Archives of Medical Research | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |