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Design, synthesis and molecular modeling studies on novel moxifloxacin derivatives as potential antibacterial and antituberculosis agents
Türe, Aslı; Kulabaş, Necla; Dingiş, Serap İpek; Birgül, Kaan; Bozdeveci, Arif; Karaoğlu, Şengül Alpay; Krishna, Vagolu Siva; Sriram, Dharmarajan; Küçükgüzel, İlkay (Academic Press Inc Elsevier Science, 2019)Twenty-one novel alkyl/acyl/sulfonyl substituted fluoroquinolone derivatives were designed, synthesized and evaluated for their anti-tuberculosis and antibacterial activity. the targeted compounds were synthesized by the ... -
Novel fluoroquinolones containing 2-arylamino-2-oxoethyl fragment: Design, synthesis, evaluation of antibacterial and antituberculosis activities and molecular modeling studies
Kulabaş, Necla; Türe, Aslı; Bozdeveci, Arif; Krishna, Vagolu Siva; Karaoğlu, Şengül Alpay; Sriram, Dharmarajan; Küçükgüzel, İlkay (Wiley, 2022)Novel substituted fluoroquinolone derivatives, compounds 6-20 were designed, synthesized, and evaluated for antituberculosis and antibacterial activity. Antibacterial activities of the compounds were determined and compound ... -
Synthesis, and prediction of molecular properties and antimicrobial activity of some acylhydrazones derived from N-(arylsulfonyl)methionine
Tatar, Esra; Şenkardeş, Sevil; Sellitepe, Hasan Erdinç; Küçükgüzel, Şükriye Güniz; Karaoğlu, Şengül Alpay; Bozdeveci, Arif; De Clercq, Erik; Pannecouque, Christophe; Ben Hadda, Taibi; Küçükgüzel, İlkay (Scientific Technical Research Council Turkey-Tubitak, 2016)A series of 38 new acylhydrazones [3-40], derived from (2S)-4-(methylsulfanyl)-2-[[(4-methylphenyl)sulfonyl] amino]butanoic acid hydrazide [2], were synthesized and evaluated for their anti-HIV and antimicrobial activity ... -
Synthesis, and prediction of molecular properties and antimicrobial activity ofsome acylhydrazones derived fromN-(arylsulfonyl)methionine
Tatar, Esra; Şenkardeş, Sevil; Sellitepe, Hasan Erdinç; Küçükgüzel, Şükriye Güniz; Karaoğlu, Şengül Alpay; Bozdeveci, Arif; De Clercq, Erik; Pannecouque, Christophe; Ben Hadda, Taibi; Küçükgüzel, İlkay (2016)A series of 38 new acylhydrazones [3{40], derived from (2S)-4-(methylsulfanyl)-2-[[(4-methylphenyl)sulfonyl]amino]butanoic acid hydrazide [2], were synthesized and evaluated for their anti-HIV and antimicrobial activity ...