Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds
Citation
Özdemir, S. B., Cebeci, Y. U., Bayrak, H., Mermer, A., Ceylan, S., Demirbaş, A., ... & Demirbaş, N. (2017). Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds. Heterocyclic Communications, 23(1), 43-54. https://doi.org/10.1515/hc-2016-0125Abstract
The hydrazide 5, that was obtained from -1-(4-fluorophenyl) piperazine (1), was converted to the cor-responding carbothioamides 6a-c by the reaction with alkyl(aryl) isothiocyanates. the synthesis of conazole analogs 10a-f was performed via the intermediary of triazoles 7a-c. the condensation of triazoles 7a-c with -several -heterocyclic amines in the presence of formalde-hyde afforded the corresponding N-aminoalkylated tria-zoles 11-14. the effect of different catalysts and solvents on conventional and microwave (MW)-prompted reac-tions was examined. the synthesized compounds were screened for their antimicrobial activities.
