Yazar "Demir, Selim" için Meslek Yüksekokulları listeleme
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Alpha-pinene neutralizes cisplatin-induced reproductive toxicity in male rats through activation of Nrf2 pathway
Demir, Selim; Menteşe, Ahmet; Türkmen Usta, Zeynep; Türkmen Alemdar, Nihal; Ayazoğlu Demir, Elif; Aliyazıcıoğlu, Yüksel (Springer, 2023)Purpose Testicular toxicity is one of the most important side efects of cisplatin (CP) therapy. Alpha-pinene (AP) is a naturally occurring monoterpene with antioxidant character in plants. Here, we aimed to evaluate the ... -
Ameliorative effect of gallic acid on cisplatin-induced ovarian toxicity in rats
Ayazoğlu Demir, Elif; Menteşe, Ahmet; Livaoğlu, Ayten; Türkmen Alemdar, Nihal; Demir, Selim (Taylor & Francis Ltd., 2021)The aim of the present study was to evaluate the protective effect of gallic acid (GA) against cisplatin (CDDP)-induced ovarian toxicity, for the first time. The ovarian damage was generated with CDDP (5 mg/kg) intraperitoneally ... -
The ameliorative effect of Primula vulgaris on cisplatin-induced nephrotoxicity in rats and quantification of its phenolic components using LC-ESI-MS/MS
Turan, İbrahim; Canbolat, Deniz; Demir, Selim; Kerimoğlu, Gökçen; Çolak, Fatih; Türkmen Alemdar, Nihal; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)Cisplatin (CDDP) is an important chemotherapeutic agent, accumulation of which in kidney tissue causes nephrotoxicity and renal failure. The aim of this study was to evaluate, for the first time in the literature, the ... -
Arbutin abrogates testicular ischemia/reperfusion injury in rats through repression of inflammation and ER stress
Demir, Elif Ayazoğlu; Demir, Selim; Kazaz, İlke Onur; Küçük, Hatice; Alemdar, Nihal Türkmen; Büyük, Ali; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)The aim of this study was to investigate the effects of arbutin (ARB) administration on oxidative stress, inflammation, endoplasmic reticulum (ER) stress and apoptosis in an experimental testicular torsion/detorsion ... -
Chlorogenic acid ameliorates torsion/detorsion-induced testicular injury via decreasing endoplasmic reticulum stress
Kazaz, İlke Onur; Demir, Selim; Kerimoğlu, Gökçen; Çolak, Fatih; Türkmen Alemdar, Nihal; Doğan, Sedanur Yılmaz; Bostan, Serdar; Menteşe, Ahmet (Elsevier, 2022)Backround Testicular torsion (TT) is an urological emergency situation especially in adolescents and young men. The main pathophysiology of testicular torsion/detorsion (T/D) is ischemia-reperfusion (I/R) injury. I/R ... -
Chlorogenic acid attenuates cisplatin-induced ovarian injury in rats
Demir, Elif Ayazoğlu; Menteşe, Ahmet; Livaoğlu, Ayten; Alemdar, Nihal Türkmen; Aliyazıcıoğlu, Yüksel; Demir, Selim (Taylor & Francis Ltd., 2023)The aim of this study was to determine the possible therapeutic effect of chlorogenic acid (CGA) on cisplatin (CDDP)-induced ovarian damage in rats. Rats were first exposed to CDDP (5 mg/kg) and then treated CGA (1.5 and ... -
Effect of chrysin on endoplasmic reticulum stress in a rat model of testicular torsion
Kazaz, İlke Onur; Demir, Selim; Kerimoğlu, Gökçen; Çolak, Fatih; Alemdar, Nihal Türkmen; Akman, Ahmet Uğur; Çeküç, Ozan Can; Menteşe, Ahmet (Taylor & Francis Ltd., 2021)Background The purpose of this study was to evaluate the possible therapeutic effect of chrysin (CHS) on testicular torsion/detorsion (T/D) injury in vivo through the mechanisms of oxidative stress and endoplasmic reticulum ... -
The effect of rosa pimpinellifolia extract on the proliferation of human tumor cells
Demir, Elif Ayazoğlu; Demir, Selim; Türkmen, Nihal; Turan, İbrahim (Kahramanmaras Sutcu Imam University, 2021)The aim of this study was to evaluate the antioxidant properties of R. pimpinellifolia and its cytotoxic effect against human colon (WiDr), liver (HepG2) and lung (A549) cancer cells compared with a normal fibroblast (BJ) ... -
Ethyl pyruvate attenuates cisplatin-induced ovarian injury in rats via activating Nrf2 pathway
Demir, Selim; Menteşe, Ahmet; Küçük, Hatice; Yuluğ, Esin; Alemdar, Nihal Türkmen; Demir, Elif Ayazoğlu; Aliyazıcıoğlu, Yüksel (Taylor & Francis Ltd., 2023)Although cisplatin (CDDP) is an antineoplastic drug widely used for the treatment of various tumors, its toxicity on the reproductive system is a concern for patients. Ethyl pyruvate (EP) possesses potent antioxidant and ... -
Evaluation of the therapeutic effects of arbutin on cisplatin-induced ovarian toxicity in rats through endoplasmic reticulum stress and Nrf2 pathway
Ayazoğlu Demir, Elif; Menteşe, Ahmet; Yılmaz, Zeynep Sağnak; Türkmen Alemdar, Nihal; Demir, Selim; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)Arbutin (ARB) is a glycosylated hydroquinone with potent antioxidant effects. Although cisplatin (CP) is widely used in chemotherapy, its toxicity in healthy tissues, including ovotoxicity, is an insurmountable problem. ... -
Gallic acid attenuates torsion/detorsion-induced testicular injury in rats through suppressing of HMGB1/NF- κB axis and endoplasmic reticulum stress
Demir, Selim; Kazaz, İlke Onur; Kerimoğlu, Gökçen; Alemdar, Nihal Türkmen; Çolak, Fatih; Arıcı, Tuğba; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Elsevier, 2024)It was aimed to evaluate whether gallic acid (GA) have a beneficial effect in the testicular ischemia/reperfusion injury (IRI) model in rats for the first time. Testicular malondialdehyde, 8-hydroxy-2 '-deoxyguanosine, ... -
Gentisic acid ameliorates cisplatin-induced reprotoxicity through suppressing endoplasmic reticulum stress and upregulating Nrf2 pathway
Menteşe, Ahmet; Demir, Selim; Aydın Mungan, Sevdegül; Alemdar, Nihal Türkmen; Ayazoğlu Demir, Elif; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)Reproductive toxicity is a serious side effect of cisplatin (CP) chemotherapy. Gentisic acid (GTA) is a phenolic acid with strong antioxidant properties. Here, we aimed to determine therapeutic effect of GTA against ... -
Gentisic acid attenuates 5-fluorouracil-induced ovotoxicity in rats via modulating Nrf2 signalling: An experimental approach
Menteşe, Ahmet; Demir, Selim; Yuluğ, Esin; Küçük, Hatice; Alemdar, Nihal Türkmen; Demir, Elif Ayazoğlu; Aliyazıcıoğlu, Yüksel (Elsevier, 2024)5-Fluorouracil (5-FU) is the third most used chemotherapeutic in the world with its anticancer effect resulting from its potential to block DNA replication. Like other cytotoxic agents, 5-FU has side effects on healthy ... -
An investigation of the protective effect of rhododendron luteum extract on cisplatin-induced DNA damage and nephrotoxicity and biochemical parameters in rats
Turan, İbrahim; Canbolat, Deniz; Demir, Selim; Kerimoğlu, Gökçen; Çolak, Fatih; Alemdar, Nihal Türkmen; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (University of Agriculture, 2023)The nephrotoxicity mechanisms caused by cisplatin (CP), which is used in the treatment of different types of cancer, include several processes, such as DNA damage, apoptosis, inflammation, and oxidative stress. This study ... -
N-acetylcysteine ameliorates 5-fluorouracil-induced ovarian injury in rats
Demir, Elif Ayazoğlu; Menteşe, Ahmet; Küçük, Hatice; Alemdar, Nihal Türkmen; Demir, Selim; Aliyazıcıoğlu, Yüksel (Marmara Üniversitesi, 2023)Objective: Although 5-fluorouracil (5-FU) is one of the most commonly used chemotherapeutics worldwide, it has been shown that 5-FU administration can cause reproductive toxicity in recent years. N-acetylcysteine (NAC) is ... -
p-Coumaric acid alleviates cisplatin-induced ovarian toxicity in rats
Ayazoğlu Demir, Elif; Menteşe, Ahmet; Küçük, Hatice; Türkmen Alemdar, Nihal; Demir, Selim (Wiley, 2021)Objective The therapeutic value of cisplatin (CDDP) as an anticancer drug is limited by its ovo-otoxicity. The effect of natural phenolic acids in the prevention of many diseases related to oxidative stress has been reported. ... -
Suppression of cisplatin-induced ovarian injury in rats by chrysin: an experimental study
Menteşe, Ahmet; Türkmen Alemdar, Nihal; Livaoğlu, Ayten; Demir, Elif Ayazoğlu; Aliyazıcıoğlu, Yüksel; Demir, Selim (Taylor & Francis Ltd., 2022)The aim of this study was to investigate the potential therapeutic efficacy of chrysin (CHS) against ovotoxicity caused by intraperitoneal administration of cisplatin (CDDP) in rats. In this experimental study, 24 female ... -
Syringic acid ameliorates ischemia/reperfusion-induced testicular injury in rats via suppressing of HMGB1/NF-kappa B axis and endoplasmic reticulum stress
Demir, Elif Ayazoğlu; Demir, Selim; Kazaz, İlke Onur; Küçük, Hatice; Alemdar, Nihal Türkmen; Geçici, Ömer Faruk; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Springer, 2023)PurposeTo investigate the possible protective role of syringic acid on torsion/detorsion-induced testicular injury using biochemical and histopathological approaches for the first time.MethodsA total of 24 rats were divided ... -
The therapeutic effect of silibinin against 5-fluorouracil-induced ovarian toxicity in rats
Demir, Elif Ayazoğlu; Menteşe, Ahmet; Küçük, Hatice; Alemdar, Nihal Türkmen; Demir, Selim (Wiley, 2023)5-Fluorouracil (5-FU) is a fluoropyrimidine group antineoplastic drug with antimetabolite properties and ovotoxicity is one of the most important side effects. Silibinin (SLB) is a natural compound that is used worldwide ... -
Usnic acid alleviates testicular ischemia/reperfusion injury in rats by modulating endoplasmic reticulum stress
Demir, Selim; Kazaz, İlke Onur; Mungan, Sevdegül Aydın; Alemdar, Nihal Türkmen; Perolli, Nijazi; Demir, Elif Ayazoğlu; Menteşe, Ahmet (Elsevier, 2024)Testicular torsion (TT) is a urological condition that can result in infertility in men. The etiopathogenesis of TT includes ischemia/reperfusion injury (IRI) characterized by oxidative stress (OS), inflammation and apoptosis ...