Yazar "Mercantepe, Tolga" için Meslek Yüksekokulları listeleme
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Agomelatine attenuates cisplatin-induced cognitive impairment via modulation of BDNF/TrkB signaling in rat hippocampus
Saral, Sinan; Topçu, Atilla; Alkanat, Mehmet; Mercantepe, Tolga; Şahin, Zafer; Akyıldız, Kerimali; Karataş, Kader Semra; Yıldız, Lamiye; Tümkaya, Levent; Yazıcı, Zihni Açar (Elsevier, 2023)Cisplatin is a drug used effectively in the treatment of malignant tumors. However, cisplatin has many side ef-fects, including cognitive impairment. Agomelatine, a synthetic melatonin analogue, is an important antide-pressant. ... -
Agomelatine on cisplatin-induced nephrotoxicity via oxidative stress and apoptosis
Dil, Eyüp; Topçu, Atilla; Mercantepe, Tolga; Tümkaya, Levent; Akyıldız, Kerimali; Saral, Sinan; Yılmaz, Adnan (Springer, 2023)Drug-induced nephrotoxicity is the greatest deterrent to the use of cisplatin, which is a frequently used chemotherapeutic with proven efectiveness in cancer therapy. Agomelatine, which is used in the treatment of sleep ... -
Apelin-13 activates the hippocampal BDNF/TrkB signaling pathway and suppresses neuroinflammation in male rats with cisplatin-induced cognitive dysfunction
Saral, Sinan; Topçu, Atilla; Alkanat, Mehmet; Mercantepe, Tolga; Akyıldız, Kerimali; Yıldız, Lamiye; Tümkaya, Levent; Yazıcı, Zihni Açar; Yılmaz, Adnan (Elsevier, 2021)It has been established that cisplatin causes neuronal damage and cognitive impairment. However, the mechanism is not sufficiently clear. Apelin-13 is an endogenous peptide with strong neuroprotective effects through the ... -
Comparative analysis of epigallocatechin-3-gallate and TNF-alpha inhibitors in mitigating cisplatin-induced pancreatic damage through oxidative stress and apoptosis pathways
Çiftel, Enver; Mercantepe, Filiz; Mercantepe, Tolga; Akyıldız, Kerimali; Yılmaz, Adnan; Çiftel, Serpil (Springer, 2024)Oxidative stress and inflammation caused by cisplatin, which is frequently used in the treatment of many cancers, damage healthy tissues as well as cancer cells. In this study, we aimed to investigate the effect of ... -
The effects of apelin-13 against cisplatin-induced nephrotoxicity in rats
Topçu, Atilla; Saral, Sinan; Mercantepe, Tolga; Akyıldız, Kerimali; Tümkaya, Levent; Yılmaz, Adnan (Taylo & Francis Ltd., 2021)Acute kidney injury (AKI) is observed in nearly 60% of patients undergoing cisplatin (CP) therapy. The aim of this study was to reveal the potential effects of apelin-13 (AP-13) in the prevention of CP-induced renal toxicity, ... -
The effects of dexmedetomidine on abdominal aortic occlusion-induced ovarian injury via oxidative stress and apoptosis
Mercantepe, Filiz; Tümkaya, Levent; Mercantepe, Tolga; Akyıldız, Kerimali; Çiftel, Serpil; Yılmaz, Adnan (Karger, 2023)Ischemia/reperfusion (IR) induced ovarian damage is caused by various diseases such as ovarian torsion, ovarian transplantation, cardiovascular surgery, sepsis, or intra-abdominal surgery. I/R-related oxidative damage can ... -
Effects of gadolinium-based MRI contrast agents on liver tissue
Mercantepe, Tolga; Tümkaya, Levent; Çeliker, Fatma Beyazal; Suzan, Zehra Topal; Çınar, Seda; Akyıldız, Kerimali; Mercantepe, Filiz; Yılmaz, Adnan (Wiley, 2018)BackgroundPurposeMRI with contrast is often used clinically. However, recent studies have reported a high accumulation of gadolinium-based contrast agents (GBCAs) in kidney, liver, and spleen tissues in several mouse models. ... -
The impact of apelin-13 on cisplatin-induced endocrine pancreas damage in rats: an in vivo study
Çiftel, Serpil; Tümkaya, Levent; Saral, Sinan; Mercantepe, Tolga; Akyıldız, Kerimali; Yılmaz, Adnan; Mercantepe, Tolga (Springer, 2024)Apelin-13 is a peptide hormone that regulates pancreatic endocrine functions, and its benefits on the endocrine pancreas are of interest. This study aims to investigate the potential protective effects of apelin-13 in ... -
Melatonin ameliorates periodontitis related inflammatory stress at cardiac left ventricular tissues in rats
Köse, Oğuz; Bayraktar, Sevda Kurt; Akyıldız, Kerimali; Altın, Ahmet; Arabacı, Taner; Yemenoğlu, Hatice; Korkmaz, Mehmet Zihni; Köse, Taha Emre; Şener, Leyla Türker; Mercantepe, Tolga; Tümkaya, Levent; Yılmaz, Adnan (Wiley, 2020)BackgroundThe aim of this experimental rat study was to investigate the potential inflammatory effects of periodontitis on cardiac left ventricular tissue and the therapeutic activity of melatonin on these effects. ... -
Prenatal effects of a 1,800-MHz electromagnetic field on rat livers
Tümkaya, Levent; Yılmaz, Adnan; Akyıldız, Kerimali; Mercantepe, Tolga; Yazıcı, Zihni Acar; Yılmaz, Hamit (Karger, 2019)The use of devices, including mobile phones, generating electromagnetic fields (EMF) is widespread and is progressively increasing. It has also been shown that EMF may have detrimental effects. This is the first study to ... -
Preventive effects of melatonin on periodontal tissue destruction due to psychological stress in rats with experimentally induced periodontitis
Bostan, Semih Alperen; Yemenoğlu, Hatice; Köse, Oğuz; Akyıldız, Kerimali; Mercantepe, Tolga; Saral, Sinan; Tümkaya, Levent; Yılmaz, Adnan (Wiley, 2024)Objective and Background: Psychological stress is a potential modifiable environmental risk factor causally related to the exacerbation of periodontitis and other chronic inflammatory diseases. This animal study aimed to ... -
Protective effect of astaxanthin against cisplatin-induced gastrointestinal toxicity in rats
Yılmaz, Yeliz; Tümkaya, Levent; Mercantepe, Tolga; Akyıldız, Kerimali (Springer Wien, 2022)Background the aim of the present study was to demonstrate astaxanthin's attenuating effects against cisplatin (CIS)-induced gastrointestinal toxicity in a rat model. Methods Thirty-two Wistar rats (weight 200-250 g) were ... -
Protective effect of vaccinium myrtillus extract on x-ray irradiation-induced retinal toxicity via enos and 8-ohdgexpression
Fındık, Hüseyin; Aslan, Mehmet Gökhan; Okutucu, Murat; Yılmaz, Adnan; Tümkaya, Levent; Mercantepe, Tolga; Akyıldız, Kerimali; Uzun, Fatma (Karger, 2023)Every year, hundreds of thousands of cancer patients receive radiotherapy treatment. Oxidative stress is observed in healthy tissues due to irradiation exposure. The present study is the first to address the effects of ... -
The protective effects of astaxanthin against cisplatin-induced retinal toxicity
Fındık, Hüseyin; Tümkaya, Levent; Yılmaz, Adnan; Aslan, Mehmet Gökhan; Okutucu, Murat; Akyıldız, Kerimali; Mercantepe, Tolga (Taylor & Francis Ltd, 2019)Purpose: This study investigated the toxic effects of an antineoplastic agent, cisplatin (CIS), on retinal cells and the potential capacity of astaxanthin (ASTA) to elicit a future therapeutic protocol in CIS-induced retinal ... -
Tea grape reduces abdominal aortic occlusion-induced lung injury
Hemşinli, Doğuş; Ergene, Şaban; Karakişi, Sedat Ozan; Mercantepe, Tolga; Tümkaya, Levent; Yılmaz, Adnan; Akyıldız, Kerimali (Soc Brasil Cirurgia Cardiovasc, 2020)Introduction: Ischemia-associated mortality caused by aortic cross-clamps, as in ruptured abdominal aorta aneurysm surgeries, and reperfusion following their removal represent some of the main emergency conditions in ...