dc.contributor.author | Emir, Abdurrahman | |
dc.contributor.author | Kalkan, Yıldıray | |
dc.contributor.author | Bostan, Habib | |
dc.date.accessioned | 2020-12-19T19:50:29Z | |
dc.date.available | 2020-12-19T19:50:29Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Emir, A., Kalkan, Y., & Bostan, H. (2016). Histopathological effects of intramuscular metamizole sodium on rat sciatic nerve. Iranian journal of basic medical sciences, 19(8), 829–836. | en_US |
dc.identifier.issn | 2008-3866 | |
dc.identifier.issn | 2008-3874 | |
dc.identifier.uri | https://hdl.handle.net/11436/2434 | |
dc.description | WOS: 000389136100004 | en_US |
dc.description | PubMed: 27746863 | en_US |
dc.description.abstract | Objective(s): We investigated the histopathological effects of metamizole sodium (MS) on the sciatic nerve. Materials and Methods: This study was performed using 48 adult male Wistar albino rats. Ten groups were constituted with 6 rats in each group. MS injection into the sciatic nerve (group 1), MS injection into the muscle [group 3 (50 mg/kg, 0.4 ml) and group 5 (50 mg/kg, 0.8 ml)], MS injection into the muscle cavity in the vicinity of the sciatic nerve [group 2 (50 mg/kg, 0.4 ml) and group 4 (50 mg/kg, 0.8 ml)], normal saline injection into the muscle in the vicinity of the sciatic nerve [group 6A (0.4 ml) and 6B (0.8 ml)], subjected to injury by drilling the entire layer of nerve without injecting any drug, normal saline injection in the sciatic nerve, and control group. Nerve and muscle samples were taken 7 days after administrations. Tissue sections were stained using a hematoxylin and eosin-Luxol (R) fast blue stain, assessed by a histologist. Results: the levels of axonal degeneration of the rats in groups 1, 2, 3, 4, 5, 6A, and 8 were found to be significantly higher compared to the levels of the rats in the control group (P< 0.05). Myelin degeneration of the rats in all groups was found to be significantly higher compared to myelin degeneration of the rats in the control group (P< 0.05). Conclusion: It was observed that MS could lead to injury in the sciatic nerve with a toxic effect due to diffusion. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Mashhad Univ Med Sciences | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Histopathology | en_US |
dc.subject | Metamizole | en_US |
dc.subject | Rat | en_US |
dc.subject | Sciatic nerve | en_US |
dc.title | Histopathological effects of intramuscular metamizole sodium on rat sciatic nerve | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Kalkan, Yıldıray | |
dc.identifier.volume | 19 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.startpage | 829 | en_US |
dc.identifier.endpage | 836 | en_US |
dc.ri.edit | oa | en_US |
dc.relation.journal | Iranian Journal of Basic Medical Sciences | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |