Difficulties in the treatment of an Infant with Hemophilia B
Citation
Ozkasap, S., Dereci, S., Ozdemir, G.N., Zulfikar, B. (2016). Difficulties in the treatment of an Infant with Hemophilia B. Turk Pediatri Arsivi-Turkish Archives of Pediatrics, 51(2), 120+. https://doi.org/10.5152/TurkPediatriArs.2016.3626Abstract
Hemophilia B is a X-linked recessive bleeding disorder
which occurs as a result of Factor IX (FIX) deficiency (1,
2). In some patients with hemophilia, antibody (inhibitor) and allergic reaction may develop against FIX protein
which is administered for treatment (3). While antibody
develops against the factor administered in approximately 15-25% of the patients with severe hemophilia
A, this rate is much lower in patients with hemophilia B
(3%). Life-threatening allergic reactions may develop in
50% of the patients who have inhibitor (4).