dc.contributor.author | Yolaş, Coşkun | |
dc.contributor.author | Özdemir, Nuriye Güzin | |
dc.contributor.author | Kanat, Ayhan | |
dc.contributor.author | Aydın, Mehmet Dumlu | |
dc.contributor.author | Keleş, Papatya | |
dc.contributor.author | Kepoğlu, Ümit | |
dc.contributor.author | Aydın, Nazan | |
dc.contributor.author | Gündoğdu, Cemal | |
dc.date.accessioned | 2020-12-19T19:50:59Z | |
dc.date.available | 2020-12-19T19:50:59Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Yolas, C., Ozdemir, N. G., Kanat, A., Aydin, M. D., Keles, P., Kepoglu, U., Aydin, N., & Gundogdu, C. (2016). Uncovering a New Cause of Obstructive Hydrocephalus Following Subarachnoid Hemorrhage: Choroidal Artery Vasospasm-Related Ependymal Cell Degeneration and Aqueductal Stenosis-First Experimental Study. World neurosurgery, 90, 484–491. https://doi.org/10.1016/j.wneu.2016.03.049 | en_US |
dc.identifier.issn | 1878-8750 | |
dc.identifier.issn | 1878-8769 | |
dc.identifier.uri | https://doi.org/10.1016/j.wneu.2016.03.049 | |
dc.identifier.uri | https://hdl.handle.net/11436/2493 | |
dc.description | AYDIN, Nazan/0000-0003-3232-7713; Gundogdu, Cemal/0000-0003-2857-923X; Kanat, Ayhan/0000-0002-8189-2877 | en_US |
dc.description | WOS: 000380360500060 | en_US |
dc.description | PubMed: 27020981 | en_US |
dc.description.abstract | BACKGROUND: Hydrocephalus is a serious complication of subarachnoid hemorrhage (SAH). Obstruction of the cerebral aqueduct may cause hydrocephalus after SAH. Although various etiologic theories have been put forward, choroidal artery vasospasm-related ependymal desquamation and subependymal basal membrane rupture as mechanisms of aqueductal stenosis have not been suggested in the literature. METHODS: This study was conducted on 26 hybrid rabbits. Five rabbits were placed in a control group, 5 were placed in a sham group, and the remaining rabbits (n = 16) were placed in the SAH group. in the first 2 weeks, 5 animals in the SAH group died. the other 21 animals were decapitated after the 4-week follow-up period. Choroidal artery changes resulting from vasospasm, aqueduct volume, ependymal cell density, and Evans index values of brain ventricles were obtained and compared statistically. RESULTS: Mean aqueduct volume was 1.137 mm(3) +/- 0.096, normal ependymal cell density was 4560/mm(2) +/- 745, and Evans index was 0.32 +/- 0.05 in control animals (n = 5); these values were 1.247 mm(3) +/- 0.112, 3568/mm(2) +/- 612, and 0.34 +/- 0.15 in sham animals (n = 5); 1.676 mm(3) +/- 0.123, 2923/mm(2) +/- 591, and 0.43 +/- 0.09 in animals without aqueductal stenosis (n = 5); and 0.650 mm(3) +/- 0.011, 1234/mm(2) +/- 498, and 0.60 +/- 0.18 in animals with severe aqueductal stenosis (n = 6). the choroidal vasospasm index values were 1.160 +/- 0.040 in the control group, 1.150 +/- 0.175 in the sham group, 1.760 +/- 0.125 in the nonstenotic group, and 2.262 +/- 0.160 in the stenotic group. Aqueduct volumes, ependymal cell densities, Evans index, and choroidal artery vasospasm index values were statistically significantly different between groups (P<0.05). CONCLUSIONS: Ependymal cell desquamation and subependymal basal membrane destruction related to choroidal artery vasospasm may lead to aqueductal stenosis and hydrocephalus after SAH. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Science Inc | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Aqueductal stenosis | en_US |
dc.subject | Choroidal artery vasospasm | en_US |
dc.subject | Ependymal cell desquamation | en_US |
dc.subject | Hydrocephalus | en_US |
dc.subject | Subarachnoid hemorrhage | en_US |
dc.title | Uncovering a new cause of obstructive hydrocephalus following subarachnoid hemorrhage: choroidal artery vasospasm-related ependymal cell degeneration and aqueductal stenosis-first experimental study | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Kanat, Ayhan | |
dc.identifier.doi | 10.1016/j.wneu.2016.03.049 | |
dc.identifier.volume | 90 | en_US |
dc.identifier.startpage | 484 | en_US |
dc.identifier.endpage | 491 | en_US |
dc.relation.journal | World Neurosurgery | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |