dc.contributor.author | Karaali, Nesrin | |
dc.contributor.author | Menteşe, Emre | |
dc.date.accessioned | 2020-12-19T19:55:36Z | |
dc.date.available | 2020-12-19T19:55:36Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Karaali, N., Mentese, E. (2016). Synthesis and study of antitumor activity of some new 2-(4-methoxybenzyl)-1h-benzimidazole derivatives bearing triazole, oxadiazole and ethanol moiety. Revue Roumaine de Chimie, 61(3), 187-192. | en_US |
dc.identifier.issn | 0035-3930 | |
dc.identifier.uri | https://hdl.handle.net/11436/2559 | |
dc.description | WOS: 000381065300006 | en_US |
dc.description.abstract | A series of novel 1,2-disubstituted benzimidazole derivatives containing hydrazinecarbothioamide (7a-c), 1,2,4-triazole (8a-c) and 1,3,4-oxadiazole (5) moiety were synthesized starting from 2-(4-methoxybenzyl)-1H-benzimidazole. Then, the compounds 8a-c, 5 were converted to allcylated analogs (9a-c, 6) in the presence of K2CO3 and 2-bromoethanol. the structures of all the synthesized compounds were elucidated by H-1, C-13 NMR and mass spectroscopy. the newly synthesized compounds were tested on the five human cancer cells (breast (BT-20), melanoma (SK-Mel 128), prostate (DU-145), liver (SNU-398) andlung (A549)). the compound 7a had some degree of cytotoxicity against BT-20. | en_US |
dc.description.sponsorship | Department of Scientific Research Project of Recep Tayyip Erdogan University [2014.102.02.03] | en_US |
dc.description.sponsorship | We thank Department of Scientific Research Project of Recep Tayyip Erdogan University for financial assistance (Project no: 2014.102.02.03). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Editura Acad Romane | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Benzimidazole | en_US |
dc.subject | Carbothioamide | en_US |
dc.subject | 1,2,4-triazole | en_US |
dc.subject | 1,3,4-oxadiazole | en_US |
dc.subject | Antitumor activity | en_US |
dc.title | Synthesis and study of antitumor activity of some new 2-(4-methoxybenzyl)-1h-benzimidazole derivatives bearing triazole, oxadiazole and ethanol moiety | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Karaali, Nesrin | |
dc.contributor.institutionauthor | Menteşe, Emre | |
dc.identifier.volume | 61 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 187 | en_US |
dc.identifier.endpage | 192 | en_US |
dc.relation.journal | Revue Roumaine de Chimie | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |