dc.contributor.author | Üçüncü, Yılmaz | |
dc.contributor.author | Çelik, Nuray | |
dc.contributor.author | Öztürk, Cengiz | |
dc.contributor.author | Türkoğlu, Murat | |
dc.contributor.author | Çetin, Nihal | |
dc.contributor.author | Koçkara, Nizamettin | |
dc.contributor.author | Şener, Ebru | |
dc.contributor.author | Dündar, Cihat | |
dc.contributor.author | Arslan, Aynur | |
dc.contributor.author | Doğan, Hasan | |
dc.contributor.author | Kurt, Nezahat | |
dc.contributor.author | Süleyman, Halis | |
dc.date.accessioned | 2020-12-19T19:57:06Z | |
dc.date.available | 2020-12-19T19:57:06Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Ucuncu, Y., Celik, N., Ozturk, C., Turkoglu, M., Cetin, N., Kockara, N., Sener, E., Dundar, C., Arslan, A., Dogan, H., Kurt, N., & Suleyman, H. (2015). Chondroprotective effects of a new glucosamine combination in rats: Gene expression, biochemical and histopathological evaluation. Life sciences, 130, 31–37. https://doi.org/10.1016/j.lfs.2015.03.012 | en_US |
dc.identifier.issn | 0024-3205 | |
dc.identifier.issn | 1879-0631 | |
dc.identifier.uri | https://doi.org/10.1016/j.lfs.2015.03.012 | |
dc.identifier.uri | https://hdl.handle.net/11436/2816 | |
dc.description | Cetin, Nihal/0000-0003-3233-8009; Dogan, Hasan/0000-0002-5232-4336; Arslan, Aynur/0000-0001-5968-5823; Kurt, Nezahat/0000-0002-1685-5332; kockara, nizamettin/0000-0003-1780-0074 | en_US |
dc.description | WOS: 000354756200006 | en_US |
dc.description | PubMed: 25818190 | en_US |
dc.description.abstract | Aims: This study investigates the effect of a new combination of glucosamine hydrochloride, chondroitin sulfate, methylsulfonylmethane, Harpagophytum procumbens root extract (standardized to 3% harpagoside) and bromelain extract (GCMHB) on formalin-induced damage to cartilage tissue in the rat knee joint and evaluates this combination in comparison with another combination of glucosamine hydrochloride, chondroitin sulfate and methylsulfonylmethane (GKM). Materials and methods: Animals in the control group were injected with formalin into the knee joint (FCC). Animals in the GCMHB-500 group were given 500 mg/kg GCMHB + formalin, and those in the GKM-500 group were given 500 mg/kg GKM + formalin. Finally, a healthy group (HG) was also used. GCMHB and GKM were administered to rats orally once a day for 30 days. At the end of this period, the rats were sacrificed and the levels of MDA, NO, 8-OH/Gua, and tGSH in the knee joint tissue were measured. Analysis of IL-1 beta and TNF-alpha gene expression was done and the tissue was evaluated histopathologically. Key findings: MDA, NO and 8-OH/Gua levels and IL-1 beta and TNF-alpha gene expression were significantly lower in the GCMHB-500 group compared to the FCG group, whereas tGSH was significantly higher in the GCMHB-500 group than in the FCG group. No significant difference was found for the IL-1 beta, TNF-alpha and oxidant/antioxidant parameters between the GKM and FCG groups. the histopathological analysis showed that GCMHB could prevent damage to the cartilage joint, whereas GKM could not. Significance: GCMHB may be used clinically by comparing with GKM in the treatment of osteoarthritis. (C) 2015 Elsevier Inc. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Pergamon-Elsevier Science Ltd | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Glucosamine | en_US |
dc.subject | IL-1 beta | en_US |
dc.subject | TNF-alpha | en_US |
dc.subject | Rat | en_US |
dc.title | Chondroprotective effects of a new glucosamine combination in rats: Gene expression, biochemical and histopathological evaluation | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Üçüncü, Yılmaz | |
dc.identifier.doi | 10.1016/j.lfs.2015.03.012 | |
dc.identifier.volume | 130 | en_US |
dc.identifier.startpage | 31 | en_US |
dc.identifier.endpage | 37 | en_US |
dc.relation.journal | Life Sciences | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |