dc.contributor.author | Süleyman, Zeynep | |
dc.contributor.author | Şener, Ebru | |
dc.contributor.author | Kurt, Nezahat | |
dc.contributor.author | Çömez, Mehmet | |
dc.contributor.author | Yapanoğlu, Turgut | |
dc.date.accessioned | 2020-12-19T19:57:42Z | |
dc.date.available | 2020-12-19T19:57:42Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Suleyman, Z., Sener, E., Kurt, N., Comez, M., & Yapanoglu, T. (2015). The effect of nimesulide on oxidative damage inflicted by ischemia-reperfusion on the rat renal tissue. Renal failure, 37(2), 323–331. https://doi.org/10.3109/0886022X.2014.985996 | en_US |
dc.identifier.issn | 0886-022X | |
dc.identifier.issn | 1525-6049 | |
dc.identifier.uri | https://doi.org/10.3109/0886022X.2014.985996 | |
dc.identifier.uri | https://hdl.handle.net/11436/2877 | |
dc.description | Kurt, Nezahat/0000-0002-1685-5332 | en_US |
dc.description | WOS: 000350554300025 | en_US |
dc.description | PubMed: 25418059 | en_US |
dc.description.abstract | The objective of our study is to research biochemically and histopathologically the effect of nimesulide on oxidative damage inflicted by ischemia-reperfusion (I/R) on the rat renal tissue. Twenty-four albino Wistar type of male rats were used for the experiment. the animals were divided into groups as: renal ischemia-reperfusion control (RIR), nimesulide + renal ischemia-reperfusion of 50 mg/kg (NRIR-50), nimesulide + renal ischemia-reperfusion of 100 mg/kg (NRIR100), and sham groups (SG). in NRIR-50 and NRIR-100 groups were given nimesulide, and RIR and SG groups were given distilled water, an hour after anesthesia. Groups, except for the SG group, 1-h-ischemia and then 6-h-reperfusion were performed. in the renal tissue of the RIR group in which the malondialdehyde (MDA), myeloperoxidase (MPO), and 8-hydroxyguanine (8-OHGua) levels were measured, the COX-1 and COX-2 activities were recorded. Nimesulide at 100 mg/kg doses reduced the oxidant parameters more significantly than 50 mg/kg doses; on the other hand, it raised the antioxidant parameters. It has been shown that 100 mg/kg doses of nimesulide prevented the renal I/R damage more significantly than a dose of 50 mg/kg, which shows that nimesulide, in clinics, could be used in the prevention of I/R damage. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis Ltd | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Ischemia | en_US |
dc.subject | Nimesulide | en_US |
dc.subject | Rat | en_US |
dc.subject | Renal | en_US |
dc.subject | Reperfusion | en_US |
dc.title | The effect of nimesulide on oxidative damage inflicted by ischemia-reperfusion on the rat renal tissue | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Sağlık Yüksekokulu, Hemşirelik Bölümü | en_US |
dc.contributor.institutionauthor | Süleyman, Zeynep | |
dc.identifier.doi | 10.3109/0886022X.2014.985996 | |
dc.identifier.volume | 37 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 323 | en_US |
dc.identifier.endpage | 331 | en_US |
dc.relation.journal | Renal Failure | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |