dc.contributor.author | Menteşe, Emre | |
dc.contributor.author | Ülker, Serdar | |
dc.contributor.author | Kahveci, Bahittin | |
dc.date.accessioned | 2020-12-19T19:57:43Z | |
dc.date.available | 2020-12-19T19:57:43Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Mentse, E., Ulker, S., Kahveci, B. (2015). Synthesis and study of alpha-glucosidase inhibitory, antimicrobial and antioxidant activities of some benzimidazole derivatives containing triazole, thiadiazole, oxadiazole, and morpholine rings. Chemistry of Heterocyclic Compounds, 50(12), 1671-1682. https://doi.org/10.1007/s10593-015-1637-1 | en_US |
dc.identifier.issn | 0009-3122 | |
dc.identifier.issn | 1573-8353 | |
dc.identifier.uri | https://doi.org/10.1007/s10593-015-1637-1 | |
dc.identifier.uri | https://hdl.handle.net/11436/2880 | |
dc.description | WOS: 000349913000004 | en_US |
dc.description.abstract | A new series of 2-(4-bromobenzyl)- and 2-(4-fluorobenzyl)-1H-benzimidazole derivatives containing 1,2,4-triazole, 1,3,4-thiadiazole, 1,3,4-oxadiazole, and morpholine rings has been synthesized. the structures of the newly synthesized compounds were confirmed by H-1 and C-13 NMR and mass spectra, and all substances have been screened for their alpha-glucosidase inhibitory, antimicrobial and antioxidant activities. Hydrazide, oxadiazole, thiosemicarbazide, and 1,2,4-triazole-3-thiol derivatives showed very good ABTS scavenging activities (IC50 1.94-4.79 mu M). Oxadiazole and thiosemicarbazide derivatives also revealed notable DPPH scavenging activity. 5-[(2-(4-Bromobenzyl)-1H-benzimidazol-1-yl)methyl]-1,3,4-oxadiazole-2-thiol was found to be more potent than acarbose. 2-(4-Fluorobenzyl)-1H-benz- imidazole was effective against both Gram-positive and Gram-negative bacteria, especially, M. smegmatis. | en_US |
dc.description.sponsorship | Recep Tayyip Erdogan University, BAP, TurkeyRecep Tayyip Erdogan University [2013.102.02.10] | en_US |
dc.description.sponsorship | The authors gratefully acknowledge financial support from the Recep Tayyip Erdogan University, BAP, Turkey, through Project 2013.102.02.10. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Benzimidazole | en_US |
dc.subject | 1,3,4-oxadiazole | en_US |
dc.subject | 1,3,4-thiadiazole | en_US |
dc.subject | 1,2,4-triazole | en_US |
dc.subject | Antimicrobial activity | en_US |
dc.subject | Antioxidant activity | en_US |
dc.subject | Alpha-glucosidase inhibition | en_US |
dc.title | Synthesis and study of alpha-glucosidase inhibitory, antimicrobial and antioxidant activities of some benzimidazole derivatives containing triazole, thiadiazole, oxadiazole, and morpholine rings | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Menteşe, Emre | |
dc.contributor.institutionauthor | Ülker, Serdar | |
dc.identifier.doi | 10.1007/s10593-015-1637-1 | |
dc.identifier.volume | 50 | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.startpage | 1671 | en_US |
dc.identifier.endpage | 1682 | en_US |
dc.relation.journal | Chemistry of Heterocyclic Compounds | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |