dc.contributor.author | Aksoy, Ayşe Nur | |
dc.contributor.author | Aydın, Fatma | |
dc.contributor.author | Yılmaz, Emsal Pınar Topdağı | |
dc.contributor.author | Batmaz, Gonca | |
dc.contributor.author | Süleyman, Bahadır | |
dc.date.accessioned | 2020-12-19T19:58:18Z | |
dc.date.available | 2020-12-19T19:58:18Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Aksoy, A. N., Aydın, F., Topdagı Yılmaz, E. P., Batmaz, G., & Suleyman, B. (2015). The Effect of Controlled Reperfusion in the Prevention of Infertility Caused by Ischemia Induced in the Contralateral Ovary in Rats with Unilateral Ovariectomy. Gynecologic and obstetric investigation, 80(3), 199–205. https://doi.org/10.1159/000377701 | en_US |
dc.identifier.issn | 0378-7346 | |
dc.identifier.issn | 1423-002X | |
dc.identifier.uri | https://doi.org/10.1159/000377701 | |
dc.identifier.uri | https://hdl.handle.net/11436/2945 | |
dc.description | AKSOY, Ayse Nur/0000-0002-3793-9797 | en_US |
dc.description | WOS: 000363830900009 | en_US |
dc.description | PubMed: 25824941 | en_US |
dc.description.abstract | Background/Aims: To investigate the effectiveness of controlled reperfusion (CR) on ovarian tissue malondialdehyde, total glutathione and 8-hydroxyguanine levels and infertility rates in a rat model of induced ischemia-reperfusion (I/R) injury with unilateral oophorectomy. Methods: A total of 135 adult female albino Wistar rats were divided into 9 groups (n = 15 for each group): unilateral ovariectomy + ovarian I/R (OIR), unilateral ovariectomy alone (OEG), a sham operation group (SG), and unilateral ovariectomy + CR performed at different intervals (the clips were released 10 times for 10, 8, 6, 4, 2 or 1 s and closed again 10 times for 10, 8, 6, 4, 2 or 1 s; OCR-1-6, respectively). Five rats from each group were sacrificed, and their ovaries were removed. Results: Higher ovarian tissue malondialdehyde and 8-hydroxyguanine levels and lower ovarian tissue total glutathione levels were found in the OIR group compared with the SG, OEG and OCR-4-6 groups. the number of rats giving birth during the study period was found to be similar among the SG (n = 8), OEG (n = 8) and OCR-6 (n = 7) groups. Conclusion: These results suggest that sterility and ovarian oxidative stress caused by I/R injury decreases in parallel to the shortening of CR duration. (C) 2015 S. Karger AG, Basel | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Karger | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | lschemia | en_US |
dc.subject | Ovary | en_US |
dc.subject | Reperfusion | en_US |
dc.subject | Rat | en_US |
dc.subject | Sterility | en_US |
dc.title | The effect of controlled reperfusion in the prevention of infertility caused by ischemia induced in the contralateral ovary in rats with unilateral ovariectomy | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Süleyman, Bahadır | |
dc.identifier.doi | 10.1159/000377701 | |
dc.identifier.volume | 80 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 199 | en_US |
dc.identifier.endpage | 205 | en_US |
dc.relation.journal | Gynecologic and Obstetric Investigation | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |