dc.contributor.author | Cüre, Erkan | |
dc.contributor.author | Kırbaş, Aynur | |
dc.contributor.author | Tümkaya, Levent | |
dc.contributor.author | Cüre, Medine Cumhur | |
dc.contributor.author | Kalkan, Yıldıray | |
dc.contributor.author | Yılmaz, Arif | |
dc.contributor.author | Yüce, Süleyman | |
dc.date.accessioned | 2020-12-19T19:58:28Z | |
dc.date.available | 2020-12-19T19:58:28Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Cure, E., Kirbas, A., Tumkaya, L., Cure, M.C., Kalkan, y., Yilmaz, A., Yce, S. (2015). Protective effect of infliximab on methotrexate-induced liver injury in rats: Unexpected drug interaction. Journal of Cancer Research and Therapeutics, 11(1), 164-169. https://doi.org/10.4103/0973-1482.140809 | en_US |
dc.identifier.issn | 0973-1482 | |
dc.identifier.issn | 1998-4138 | |
dc.identifier.uri | https://doi.org/10.4103/0973-1482.140809 | |
dc.identifier.uri | https://hdl.handle.net/11436/2971 | |
dc.description | cure, erkan/0000-0001-7807-135X; Cure, Medine Cumhur/0000-0001-9253-6459 | en_US |
dc.description | WOS: 000353588000031 | en_US |
dc.description | PubMed: 25879356 | en_US |
dc.description.abstract | Aims: Although methotrexate (mtx) is a widely used agent to treat cancer and inflammatory diseases, its hepatotoxic effect limits for clinical utility. We aimed to investigate whether infliximab (inf), an inhibitor of tumor necrosis factor-alpha (TNF-alpha) has a protective effect against mtx-induced hepatotoxicity. Materials and Methods: For mtx group, the animals received an intraperitoneal single dose injection of mtx at a dose of 20 mg/kg. For inf group, the animals received an intraperitoneal single dose injection of inf at a dose of 7 mg/kg. For mtx + inf group, the single dose of inf at a dose of 7 mg/kg was given 72 h prior to mtx injection. After 72 h, a single dose of mtx 20 mg/kg was given. All rats were sacrificed 5 days after mtx injection. Results: TNF-alpha and nitric oxide (NO) levels of mtx group was significantly higher than the control (P < 0.001), inf (P < 0.001) and mtx + inf (P < 0.001) groups. Total score of histological damage was higher in the mtx group when compared with the mtx + inf group. Arginase and carbamoyl phosphate synthetase 1 (CPS-1) of mtx group was suppressed in comparison with the control group and was markedly increased in mtx + inf group. Conclusion: Inf may partially prevent mtx-induced hepatic damage in rats. However, the combined usage of mtx and inf increases arginase and CPS-1 enzyme activities and at the same time blocks TNF-alpha. This combination especially in cancer patients may lead to cancer cell invasion and metastasis. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wolters Kluwer Medknow Publications | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Arginase | en_US |
dc.subject | Carbamoyl phosphate synthetase 1 | en_US |
dc.subject | Hepatotoxicity | en_US |
dc.subject | Infliximab | en_US |
dc.subject | Methotrexate | en_US |
dc.title | Protective effect of infliximab on methotrexate-induced liver injury in rats: Unexpected drug interaction | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Cüre, Erkan | |
dc.contributor.institutionauthor | Kırbaş, Aynur | |
dc.contributor.institutionauthor | Tümkaya, Levent | |
dc.contributor.institutionauthor | Cüre, Medine Cumhur | |
dc.contributor.institutionauthor | Kalkan, Yıldıray | |
dc.contributor.institutionauthor | Yılmaz, Arif | |
dc.contributor.institutionauthor | Yüce, Süleyman | |
dc.identifier.doi | 10.4103/0973-1482.140809 | |
dc.identifier.volume | 11 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 164 | en_US |
dc.identifier.endpage | 169 | en_US |
dc.ri.edit | oa | en_US |
dc.relation.journal | Journal of Cancer Research and Therapeutics | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |