dc.contributor.author | Süleyman, Bahadır | |
dc.contributor.author | Albayrak, Abdülmecit | |
dc.contributor.author | Kurt, Nezahat | |
dc.contributor.author | Demirci, Elif | |
dc.contributor.author | Gündoğdu, Cemal | |
dc.contributor.author | Aksoy, Mehmet | |
dc.date.accessioned | 2020-12-19T20:02:55Z | |
dc.date.available | 2020-12-19T20:02:55Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Suleyman, B., Albayrak, A., Kurt, N., Demirci, E., Gundogdu, C., Aksoy, M. (2014). The effect of etoricoxib on kidney ischemia-reperfusion injury in rats: a biochemical and immunohistochemical assessment. International Immunopharmacology, 23(1), 179-185. https://doi.org/10.1016/j.intimp.2014.06.042 | en_US |
dc.identifier.issn | 1567-5769 | |
dc.identifier.issn | 1878-1705 | |
dc.identifier.uri | https://doi.org/10.1016/j.intimp.2014.06.042 | |
dc.identifier.uri | https://hdl.handle.net/11436/3031 | |
dc.description | Kurt, Nezahat/0000-0002-1685-5332; Albayrak, Abdulmecit/0000-0002-1062-1965; Gundogdu, Cemal/0000-0003-2857-923X | en_US |
dc.description | WOS: 000347019800024 | en_US |
dc.description | PubMed: 25068826 | en_US |
dc.description.abstract | The purpose of this study was to investigate the effect of etoricoxib on oxidative injury induced with ischemia-reperfusion (I/R) in rat kidney tissue in terms of biochemistry and immunohistochemistry. Male Albino Wistar rats were divided into renal I/R (RIR), 50 mg/kg etoricoxib + RIR (ETO-50), 100 mg/kg etoricoxib + RIR (ETO-100) and sham operation (SG) groups. Animals in the ETO-50 and ETO-100 groups were given etoricoxib by the oral route at dosages of 50 and 100 mg/kg, respectively. the RIR and SG groups were given distilled water as solvent. One hour after drug administration, 1 h of ischemia and 3 h of reperfusion were applied to the left kidneys of all rats (apart from SG) under 25 mg/kg thiopental sodium anesthesia. At the end of that time, kidneys were extracted and biochemical and immunohistochemical analyses were performed. Etoricoxib reduced, in a dose-dependent manner, levels of MDA, MPO and COX-2 that normally rise with I/R in rat kidney tissues. Etorixicob did not alter COX-1 activity at 50 and 100 mg/kg doses, but significantly prevented loss of tGSH in tissues with I/R. in addition, Bd-2' gene expression inhibited with I/R was prevented in renal tubular and glomerular cells. Furthermore, etoricoxib significantly decreased the caspase-3 gene expression which increased with I/R. Etoricoxib significantly prevented I/R injury in a dose-dependent manner. the results of this study show that etoricoxib treatment could decrease kidney injury during IR. (C) 2014 Elsevier B.V. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Etoricoxib | en_US |
dc.subject | Oxidant-antioxidant parameters | en_US |
dc.subject | Ischemia-reperfusion | en_US |
dc.subject | Bcl-2 | en_US |
dc.subject | Rat | en_US |
dc.title | The effect of etoricoxib on kidney ischemia-reperfusion injury in rats: a biochemical and immunohistochemical assessment | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Süleyman, Bahadır | |
dc.identifier.doi | 10.1016/j.intimp.2014.06.042 | |
dc.identifier.volume | 23 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 179 | en_US |
dc.identifier.endpage | 185 | en_US |
dc.relation.journal | International Immunopharmacology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |