dc.contributor.author | Kısaoğlu, Abdullah | |
dc.contributor.author | Özoğul, Bünyamin | |
dc.contributor.author | Turan, Mehmet İbrahim | |
dc.contributor.author | Yılmaz, İsmail | |
dc.contributor.author | Demiryılmaz, İsmail | |
dc.contributor.author | Atamanalp, Sabri Selçuk | |
dc.contributor.author | Bakan, Ebubekir | |
dc.contributor.author | Süleyman, Halis | |
dc.date.accessioned | 2020-12-19T20:03:03Z | |
dc.date.available | 2020-12-19T20:03:03Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Kisaoglu, A., Özogul, B., Turan, M.I., Yilmaz, I., Demiryilmaz, I., Atamanalp, S.S., Bakan, E., Suleyman, H., (2014).Damage induced by paracetamol compared with N-acetylcysteine.Journal of the Chinese Medical Association, 77(9), 463-468.https://doi.org/10.1016/j.jcma.2014.01.011 | |
dc.identifier.issn | 1726-4901 | |
dc.identifier.issn | 1728-7731 | |
dc.identifier.uri | https://doi.org/10.1016/j.jcma.2014.01.011 | |
dc.identifier.uri | https://hdl.handle.net/11436/3076 | |
dc.description | WOS: 000342263300005 | en_US |
dc.description | PubMed: 25028290 | en_US |
dc.description.abstract | Background: This study investigated the effect of thiamine pyrophosphate (TPP) on oxidative liver damage induced in rats with high-dose paracetamol. Methods: Rats for this experiment were divided into the following groups: healthy control, paracetamol control, thiamine + paracetamol, TPP + paracetamol, and N-acetylcysteine + paracetamol. Oxidant and antioxidant parameters and liver function test levels were compared between the groups. Results: the results show that TPP and N-acetylcysteine with paracetamol equally prevented a rise in oxidants such as malondialdehyde and nitric oxide. They also prevented a decrease in enzymatic and nonenzymatic antioxidants such as glutathione, glutathione peroxidase, glutaredoxin, glutathione S-transferase, superoxide dismutase, and catalase in the rat liver. Conclusion: Thiamine pyrophosphate and N-acetylcysteine had a similar positive effect on oxidative damage caused by paracetamol hepatotoxicity. These findings show that TPP may be beneficial in paracetamol hepatotoxicity. Copyright (C) 2014 Elsevier Taiwan LLC and the Chinese Medical Association. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Hepatotoxicity | en_US |
dc.subject | Paracetamol | en_US |
dc.subject | Rat | en_US |
dc.subject | Thiamine | en_US |
dc.subject | Thiamine pyrophosphate | en_US |
dc.title | Damage induced by paracetamol compared with N-acetylcysteine | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Süleyman, Halis | |
dc.identifier.doi | 10.1016/j.jcma.2014.01.011 | |
dc.identifier.volume | 77 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.startpage | 463 | en_US |
dc.identifier.endpage | 468 | en_US |
dc.ri.edit | oa | en_US |
dc.relation.journal | Journal of the Chinese Medical Association | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |