dc.contributor.author | Kahriman, Nuran | |
dc.contributor.author | Yaylı, Büşra | |
dc.contributor.author | Aktaş, Ayça | |
dc.contributor.author | Iskefiyeli, Zeynep | |
dc.contributor.author | Beriş, Fatih Şaban | |
dc.contributor.author | Yaylı, Nurettin | |
dc.date.accessioned | 2020-12-19T20:03:54Z | |
dc.date.available | 2020-12-19T20:03:54Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Kahriman, N., Yayli, B., Aktas, A., Iskefiyeli, Z., Beris, F.S., Yayli, N. (2013). Synthesis, antibacterial and antioxidant activities of new 1-alkyl-4-(1-alkyl-4-oxo-1,4-dihydroquinolin-2-yl)pyridinium bromides. European Journal of Medicinal Chemistry, 69, 348-355. https://doi.org/10.1016/j.ejmech.2013.08.050 | en_US |
dc.identifier.issn | 0223-5234 | |
dc.identifier.issn | 1768-3254 | |
dc.identifier.uri | https://doi.org/10.1016/j.ejmech.2013.08.050 | |
dc.identifier.uri | https://hdl.handle.net/11436/3249 | |
dc.description | AKAR, ZEYNEP/0000-0001-9262-8070 | en_US |
dc.description | WOS: 000330603900033 | en_US |
dc.description | PubMed: 24077525 | en_US |
dc.description.abstract | New 1-alkyl-4-(1-alkyl-4-oxo-1,4-dihydroquinolin-2-yl)pyridinium bromides (3a k) were synthesized from 1,4'-diazaflavone [2-pyridin-4-ylquinolin-4(1H)-one] and evaluated for antibacterial and antioxidant activities. A rapid one-pot preparation of 1,4'-diazaflavone (2) was done from 2'-amino substituted chalcone (1) by intramolecular Michael addition using solvent-free microwave heating. New N,N'-dialkyl substituted (C-5-C-15) 1,4'-diazaflavonium bromides were synthesized from compound 2 with corresponding alkyl halides. Compounds 3a k were active against six bacteria (MIC: 7.8-500.0 mu g/mL). They also showed good antioxidant activities in DPPI-1* scavenging (SC50: 45-133 mu g/mL) and ferric reducing/antioxidant power (14-141 p.M TEAC) tests. the biological activities decreased as alkyl chain length increased. the reason behind the obvious negative effect of alkyl chain elongation is unclear and requires investigations about the intermolecular interactions of these pyridinium salts with bioassay components. (C) 2013 Elsevier Masson SAS. All rights reserved. | en_US |
dc.description.sponsorship | Karadeniz Technical UniversityKaradeniz Technical University; Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TUBiTAK-109T388] | en_US |
dc.description.sponsorship | This study was supported by grants from Karadeniz Technical University and the Scientific and Technological Research Council of Turkey (TUBiTAK-109T388). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier France-Editions Scientifiques Medicales Elsevier | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Microwave | en_US |
dc.subject | 1,4 '-Diazaflavone | en_US |
dc.subject | Quinoline nucleus | en_US |
dc.subject | N,N '-Dialkyl-1,4 '-diazaflavonium bromide | en_US |
dc.subject | Antibacterial activity | en_US |
dc.subject | Antioxidant activity | en_US |
dc.title | Synthesis, antibacterial and antioxidant activities of new 1-alkyl-4-(1-alkyl-4-oxo-1,4-dihydroquinolin-2-yl)pyridinium bromides | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Biyoloji Bölümü | en_US |
dc.contributor.institutionauthor | Beriş, Fatih Şaban | |
dc.identifier.doi | 10.1016/j.ejmech.2013.08.050 | |
dc.identifier.volume | 69 | en_US |
dc.identifier.startpage | 348 | en_US |
dc.identifier.endpage | 355 | en_US |
dc.relation.journal | European Journal of Medicinal Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |