dc.contributor.author | Demircioğlu, Fatih | |
dc.contributor.author | Demirci, Umut | |
dc.contributor.author | Kılıç, Diclehan | |
dc.contributor.author | Özkan, Seçil | |
dc.contributor.author | Karahacıoğlu, Eray | |
dc.date.accessioned | 2020-12-19T20:03:55Z | |
dc.date.available | 2020-12-19T20:03:55Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Demircioglu, F., Demirci, U., Kilic, D., Ozkan, S., Karahacioglu, F. (2013). Clinical significance of lymph node ratio in locally advanced breast cancer molecular subtypes. Onkologie, 36(11), 637-640. https://doi.org/10.1159/000355663 | en_US |
dc.identifier.issn | 0378-584X | |
dc.identifier.issn | 1423-0240 | |
dc.identifier.uri | https://doi.org/10.1159/000355663 | |
dc.identifier.uri | https://hdl.handle.net/11436/3254 | |
dc.description | Demircioglu, Fatih/0000-0001-7926-5973; DEMIRCI, UMUT/0000-0002-4833-6721 | en_US |
dc.description | WOS: 000327051100002 | en_US |
dc.description | PubMed: 24192767 | en_US |
dc.description.abstract | Background: the ratio of metastatic to dissected lymph nodes (lymph node ratio; LNR) is a sensitive and superior prognostic factor for lymph node evaluation, but its relationship to cancer subtypes is unclear. Patients and Methods: Data from 469 patients with axillary lymph node metastasis out of 640 early breast cancer cases were retrospectively analyzed. They were classified into 4 molecular subtypes; lumina! A, luminal B HER2(+), HER2 overexpression, basal-like. LNRs were compared between groups and with other prognostic factors. Results: the distribution of LNRs was 35.2% in luminal A, 43.2% in luminal B HER2(+), 46.9% in HER2 overexpression, and 39.1% in basal-like. A significant difference was found between lumina! A and HER2 overexpression subtypes (p = 0.023). LNR was significantly correlated with tumor size and lymphovascular invasion, but not with other prognostic factors including menopausal status, laterality, grade, and perineural invasion. An LNR of 29.8% was defined as the cut-off value, and significant differences in survival rates were identified accordingly between basal-like and both luminal A (p = 0.003) and luminal B HER2(+) (p = 0.04). Conclusion: the LNR differs between some molecular subtypes of breast cancer, and it correlates with certain prognostic factors and survival. These data support using the LNR to assess breast cancer patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Karger | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Breast cancer | en_US |
dc.subject | Lymph node ratio | en_US |
dc.subject | Molecular subtypes | en_US |
dc.subject | Prognostic factors | en_US |
dc.title | Clinical significance of lymph node ratio in locally advanced breast cancer molecular subtypes | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Demircioğlu, Fatih | |
dc.identifier.doi | 10.1159/000355663 | |
dc.identifier.volume | 36 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.startpage | 637 | en_US |
dc.identifier.endpage | 640 | en_US |
dc.relation.journal | Onkologie | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |