dc.contributor.author | Dilek, Aziz Ramazan | |
dc.contributor.author | Dilek, Nursel | |
dc.contributor.author | Saral, Yunus | |
dc.contributor.author | Yüksel, Derya | |
dc.date.accessioned | 2020-12-19T20:04:15Z | |
dc.date.available | 2020-12-19T20:04:15Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Dilek, A.Z., Dilek, N., Saral, Y., Yuksel, D. (2013). The relationship between severity of the disease and circulating nucleosomes in psoriasis patients. Archives of Dermatological Research, 305(6), 483-487. https://doi.org/10.1007/s00403-013-1347-4 | en_US |
dc.identifier.issn | 0340-3696 | |
dc.identifier.issn | 1432-069X | |
dc.identifier.uri | https://doi.org/10.1007/s00403-013-1347-4 | |
dc.identifier.uri | https://hdl.handle.net/11436/3301 | |
dc.description | WOS: 000322029100004 | en_US |
dc.description | PubMed: 23567920 | en_US |
dc.description.abstract | Psoriasis was initially considered to represent a disease of abnormal epidermal keratinocyte proliferation. Proliferation of keratinocytes is restricted by apoptotic cell death to maintain a constant thickness of epidermis. Nucleosomes are mainly released by apoptotic cells. Tumor necrosis factor-alpha (TNF-alpha) is an important factor affecting the apoptosis. in the present study, the relationship between TNF-alpha, nucleosome and the Psoriasis Area and Severity Index (PASI) score was investigated. the patients were divided according to PASI score into three groups (mild, moderately, severe). Serum TNF-alpha and nucleosome levels were measured using Enzyme-linked immunosorbent assay (ELISA) method. Our findings show a correct relationship between PASI scores and TNF-alpha and an inverse relationship between nucleosome and PASI score. According to the results obtained from the study, we believe that serum nucleosome levels can be used as a new indicator in follow-up of patients with psoriasis and monitoring of the effectiveness of drugs which used in the treatment of psoriasis. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Psoriasis | en_US |
dc.subject | Nucleosome | en_US |
dc.subject | TNF-alpha | en_US |
dc.title | The relationship between severity of the disease and circulating nucleosomes in psoriasis patients | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Dilek, Aziz Ramazan | |
dc.contributor.institutionauthor | Dilek, Nursel | |
dc.contributor.institutionauthor | Saral, Yunus | |
dc.contributor.institutionauthor | Yüksel, Derya | |
dc.identifier.doi | 10.1007/s00403-013-1347-4 | |
dc.identifier.volume | 305 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 483 | en_US |
dc.identifier.endpage | 487 | en_US |
dc.relation.journal | Archives of Dermatological Research | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |