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The effects of Atorvastatin Therapy on rheological characteristics of erythrocyte Membrane, serum lipid profile and oxidative status in patients with dyslipidemia

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info:eu-repo/semantics/closedAccess

Date

2012

Author

Uydu, Hüseyin Avni
Yıldırmış, Sermet
Örem, Cihan
Çalapoğlu, Mustafa
Alver, Ahmet
Kural, Birgül
Örem, Asım

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Uydu, HA., Yıldırmış, S., Örem, C., Çalapoğlu, M., Alver, A., Kural, B., Örem, A. (2012). The effects of Atorvastatin Therapy on rheological characteristics of erythrocyte Membrane, serum lipid profile and oxidative status in patients with dyslipidemia. Journal of Membrane Biology, 245(11), 697-705.

Abstract

The statins, most commonly used in the treatment of hyperlipidemia, have certain beneficial effects including improved endothelial function, plaque stability and decreased oxidative stress and inflammation, beyond their lipid-lowering effect in plasma. We evaluated the pleiotropic impact of atorvastatin on erythrocyte structural/mechanical properties and lipid peroxidation in dyslipidemics. the study group included 44 patients with dyslipidemia and was divided into subgroups according to triglyceride and cholesterol levels as hypercholesterolemic (n = 29) and mixed-type hyperlipidemic (n = 15). Subjects were given 10 mg atorvastatin per day for 12 weeks. Changes in serum lipid composition, lipid contents, Na+/K+-ATPase activity and osmotic fragility in erythrocytes and oxidative stress parameters of erythrocytes and plasma were studied. Atorvastatin therapy improved the serum lipid profile of both subgroups. This alteration was accompanied by a decreased level of cholesterol in erythrocyte membranes. Moreover, enhanced activity of Na+/K+-ATPase in erythrocytes reflected the improvements in membrane lipids of both subgroups. However, a significant change was observed in osmotic fragility values of the mixed-typed dyslipidemic group. This treatment lowered the lipid peroxidation in plasma and erythrocytes and increased plasma total antioxidant capacity in all groups. the present study shows that the use of atorvastatin reversed the structural and functional features of erythrocyte membranes in dyslipidemic subjects. Also, hypolipidemic therapy had a beneficial impact on a balance between oxidant and antioxidant systems.

Source

Journal of Membrane Biology

Volume

245

Issue

11

URI

https://doi.org/10.1007/s00232-012-9441-7
https://hdl.handle.net/11436/3413

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  • PubMed İndeksli Yayınlar Koleksiyonu [2443]
  • Scopus İndeksli Yayınlar Koleksiyonu [6023]
  • TF, Temel Tıp Bilimleri Bölümü Koleksiyonu [700]
  • WoS İndeksli Yayınlar Koleksiyonu [5260]



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