Determination of the pKa of Some triazole derivatives by the potentiometric method in dioxan-water mixtures

Abstract

Stoichiometric protonation constants of some 3-alkyl(aryl)-4-(substituted benzylamino)-4,5-dihydro-1 H-1,2,4-triazol-5-ones derivatives were determined potentiometrically in 50% (v/v) dioxan-water mixtures at 25°C with an ionic strength of 0.10 M. The calculation of the stoichiometric protonation constants was carried out using a PKAS computer program. The effect of solvents composition on the stoichiometric protonation constants are discussed.