dc.contributor.author | Bektaş, Hakan | |
dc.contributor.author | Karaali, Nesrin | |
dc.contributor.author | Şahin, Deniz | |
dc.contributor.author | Demirbaş, Ahmet | |
dc.contributor.author | Karaoğlu, Şengül Alpay | |
dc.contributor.author | Demirbaş, Neslihan | |
dc.date.accessioned | 2020-12-19T20:11:44Z | |
dc.date.available | 2020-12-19T20:11:44Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Bektaş, H., Karaali, N., Şahin, D., Karaoğlu, Ş.A., Demirbaş, N. (2010). Synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives. Molecules, 15(4), 2427-2438. | |
dc.identifier.issn | 1420-3049 | |
dc.identifier.uri | https://doi.org/10.3390/molecules15042427 | |
dc.identifier.uri | https://hdl.handle.net/11436/3777 | |
dc.description | PubMed: 20428053 | en_US |
dc.description.abstract | Some novel 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one (3, 6, 8, 9) derivatives and or 3-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3]benzoxazole (5) were synthesized from the reaction of various ester ethoxycarbonylhydrazones (1a-e) with several primary amines. The synthesis of 4-amino-5-(4-chlorophenyl) -2-[(5-mercapto1,3,4-oxadiazol-2-yl)methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one (13) was performed starting from 4-Amino-5-(4-chlorophenyl)-2,4-dihydro-3H-1,2, 4-triazol-3-one (2) by four steps; then 13 was converted to the corresponding Schiff base (14) by using 4methoxybenzaldehyde. Finally, two Mannich base derivatives of 14 were obtained by using morpholine or methyl piperazine as amine component. All newly synthesized compounds were screened for their antimicrobial activities and some of which were found to possess good or moderate activities against the test microorganisms. Copyright © 2010 by the authors. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | 1,2,4-Triazole | en_US |
dc.subject | Mannich base | en_US |
dc.subject | Primary amine | en_US |
dc.subject | Schiff base | en_US |
dc.subject | Triazolo[3,4-b][1,3]benzoxazole | en_US |
dc.title | Synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Biyoloji Bölümü | en_US |
dc.contributor.institutionauthor | Karaoğlu, Şengül Alpay | |
dc.contributor.institutionauthor | | |
dc.identifier.doi | 10.3390/molecules15042427 | |
dc.identifier.volume | 15 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 2427 | en_US |
dc.identifier.endpage | 2438 | en_US |
dc.relation.journal | Molecules | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |